Leveraging Peripheral CB1 Antagonism in 1,4,5,6-Tetrahydropyridazine-Based Amidine Substituted Sulfonyl Analogs for Treating Metabolic Disorders by Pinaki Bhattacharjee (11971366)

“…CB₁ receptor antagonists that are peripherally acting hold promise for treating obesity, diabetes and fibrotic disorders highlighting their importance in treating metabolic syndrome disorders (MetS). We synthesized and evaluated compounds by integrating amidine fragments into 1,4,5,6-tetrahydropyridazine-based sulfonyl urea scaffolds for blocking CB₁ receptors. …”

Longitudinal and site-specific development of the cutaneous microbiome in preterm and term infants. by Mohan Pammi (3822313)

“…Term infants were sampled at 2 time points (birth and between 2–3 weeks of age) and preterm infants every week from birth for 5 time-points. For each skin site, the number of OTUs and Shannon diversity index in preterm infants decreased between week 1 and week 2, and then increased over time until week 5. …”

Image_5_Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses.TIF by M. Ayelén Milillo (4325953)

Image_5_Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses.TIF by M. Ayelén Milillo (4325953)

Phosphocalcic Markers and Calcification Propensity for Assessment of Interstitial Fibrosis and Vascular Lesions in Kidney Allograft Recipients by Lena Berchtold (3609173)

“…T₅₀ decreased with increasing arterial lesions (r = -0.21, p = 0.038). …”

Image_5_Cow Farmers’ Homes Host More Diverse Airborne Bacterial Communities Than Pig Farmers’ Homes and Suburban Homes.JPEG by Hesham Amin (7038827)

“…Then, quantitative PCR (qPCR) was used to assess bacterial abundance. The V3–V4 region of the bacterial 16S rRNA gene was amplified and sequenced using Ilumina MiSeq in order to assess microbial diversity. …”

Image_5_Increasing Fruit Weight by Editing a Cis-Regulatory Element in Tomato KLUH Promoter Using CRISPR/Cas9.JPEG by Qiang Li (8118)

“…Twenty-one mutant alleles with various insertion and deletion sizes were generated in the LA1589 background. Five mutant alleles (m2_+4bp, m3_+1bp, m5_–1bp, m13_–8bp, and m14_–9bp) showed a consistent increase in fruit weight and a significant decrease in the proportion of small fruits in all experimental evaluations. …”

Table_5_Periostin Contributes to Immunoglobulin a Nephropathy by Promoting the Proliferation of Mesangial Cells: A Weighted Gene Correlation Network Analysis.DOCX by Jingkui Wu (9664094)

“…We screened the GSE37460 and GSE104948 differentially expressed genes common to both datasets and identified periostin (POSTN) as one of the five key genes using the cytoHubba plugin of Cytoscape software and by receiver-operating characteristic curve analysis. …”

Image_5_OsDDM1b Controls Grain Size by Influencing Cell Cycling and Regulating Homeostasis and Signaling of Brassinosteroid in Rice.TIF by Mingliang Guo (4877395)

Image_5_Cow Farmers’ Homes Host More Diverse Airborne Bacterial Communities Than Pig Farmers’ Homes and Suburban Homes.jpg by Hesham Amin (7038827)

“…Then, quantitative PCR (qPCR) was used to assess bacterial abundance. The V3–V4 region of the bacterial 16S rRNA gene was amplified and sequenced using Ilumina MiSeq in order to assess microbial diversity. …”

Results of the spatial PCA and cluster-based permutation tests of ERSP at encoding. by Makenna B. McGill (15217451)

Preparations of DnaK protein are pure. by Carissa Chan (18310140)

Crystal Orientation Behavior and Shape-Memory Performance of Poly(vinylidene fluoride)/Acrylic Copolymer Blends by Jichun You (1468516)

“…The maximum shape-memory recovery properties were observed for the blend sample containing 50 wt % PVDF, in which a small amount of tie molecules connect the PVDF crystallites to form a deformable elastic network. …”

A comparative anticancer analysis of iron oxide nanoparticles of <i>Hippophae rhamnoides</i> and <i>Cichorium intybus</i> found in the Karakoram Range of Gilgit Baltistan against l... by Rukhsana Tabassum (11102571)

“…The gene expression and protein levels of <i>RhoA</i> were decreased whereas those of <i>bax</i>, <i>caspase 3</i>, <i>caspase 8</i> and <i>caspase 9</i> were found increased.…”

Data Sheet 1_v3_Modulation of NMDA receptor activity by CR4056, an imidazoline-2 receptor ligand with analgesic properties.pdf by Giulia Puja (8696967)

“…In primary culture of cortical neurons, application of NMDA and glycine elicits a current that is decreased in a dose-dependent fashion by CR4056 (IC₅₀ 5.3 ± 0.1 µM). …”

Feeding and starvation affect the proportion and cell cycle activity of Vasa2+/Piwi1+ cells. by Eudald Pascual-Carreras (12115380)

Table 1_The first photometric investigation of two short-period Algol-type eclipsing binaries: IW UMa and V367 Gem.pdf by Xiao-Man Tian (20532380)

“…The period of V367 Gem is decreasing at a rate of dP/dt=−7.40(± 0.43)×10−8d⋅yr−1 on a long time scale.…”

Image_1_Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization.TIF by Emelia A. Assar (9201743)

“…It is now understood that autophagy has discrete functions as a selective lysosomal degradation pathway targeting large cytosolic structural and signaling complexes to influence cell motility and adhesion. We provide evidence suggesting the primary autophagy regulators Atg5 and FIP200 both play a role in cell motility and extracellular matrix adhesion. …”

DataSheet5_β-hydroxybutyrate impairs bovine oocyte maturation via pyruvate dehydrogenase (PDH) associated energy metabolism abnormality.ZIP by Kai-Yan Zhang (529208)

“…Furthermore, oxidative stress triggered early apoptosis, as shown by the enhanced levels of Caspase-3 and Annexin-V. Moreover, 3.6 mM βHB induced the disruption of the pyruvate dehydrogenase (PDH) activity, showing with the decrease of the global acetylation modification and the increase of the abnormal spindle rate.…”

Image_2_Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization.TIF by Emelia A. Assar (9201743)

“…It is now understood that autophagy has discrete functions as a selective lysosomal degradation pathway targeting large cytosolic structural and signaling complexes to influence cell motility and adhesion. We provide evidence suggesting the primary autophagy regulators Atg5 and FIP200 both play a role in cell motility and extracellular matrix adhesion. …”