First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

Helminth co-infection results in decreased number of CD11b⁺ cells and antimicrobial peptide expression in colonic tissue. by Libo Su (596288)

Multinomial logistic model of the effects of a cluster of phenolic compounds on host and parasitoid survival across development among larvae that survived to at least 50 mg. by Noah H. Rose (703745)

Mucosal vaccination with M2e5x VLP decreases innate immune cell recruitments after influenza virus infection. by Young-Tae Lee (467116)

hESCs-CM inhibited cell cycle progression of cancer cells and initiated a pro-apoptotic program. by Shufeng Zhou (398572)

Proliferative keratinocytes and BrdU-positive label retaining cells are decreased in <i>Med1^epi−/−</i> mice. by Fumihito Noguchi (615295)

“…Scale bars = 50 µm. B: Quantification of proliferating cells on days 1, 3 and 5 after injury. …”

Knockdown of Rab27a and disruption of microtubules decreased the number of granules docked at the PM. by Dongfang Liu (241581)

The forest plot shows the comparison of FA values(A) and ADC values(B) between the stressed and healthy sides in the random effects model. by Nan Wang (21935)

Regional contemporary (1990–1999 mean) precipitation and JULES inundation fraction over the Amazon basin. by Nic Gedney (19762301)

Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment. by Luca G. Valente (12463057)

ArxE mice have almost complete loss of α-cell fate by P14 with a concomitant decrease in total endocrine mass, but no change in β- and δ-cell mass. by Crystal L. Wilcox (421799)

Relationship between OLT and soil temperature at 50-cm (a), the depth at which charcoal was measured (b), and the active layer depth (c) measured in the field for a subset of the d... by Kristofer D Johnson (557206)

“…</p> <p><strong>Abstract</strong></p> <p>Permafrost is tightly coupled to the organic soil layer, an interaction that mediates permafrost degradation in response to regional warming. We analyzed changes in permafrost occurrence and organic layer thickness (OLT) using more than 3000 soil pedons across a mean annual temperature (MAT) gradient. …”

Example of skyline query for proteins. by Rizka Fatriani (17485787)

“…The stability of the protein-ligand complex resulting from docking was examined using molecular dynamics simulations, and we observed the best average root mean square deviation (RMSD) of 0.99 Å for PPARG with trans-3-indoleacrylic acid, which was lower than with the native ligand BRL (2.02 Å). …”

Top 10 pathways with the lowest p-value. by Rizka Fatriani (17485787)

“…The stability of the protein-ligand complex resulting from docking was examined using molecular dynamics simulations, and we observed the best average root mean square deviation (RMSD) of 0.99 Å for PPARG with trans-3-indoleacrylic acid, which was lower than with the native ligand BRL (2.02 Å). …”

Pseudocode of block-nested loop (BNL). by Rizka Fatriani (17485787)

“…The stability of the protein-ligand complex resulting from docking was examined using molecular dynamics simulations, and we observed the best average root mean square deviation (RMSD) of 0.99 Å for PPARG with trans-3-indoleacrylic acid, which was lower than with the native ligand BRL (2.02 Å). …”

Top 10 gene ontologies with the lowest p-value. by Rizka Fatriani (17485787)

“…The stability of the protein-ligand complex resulting from docking was examined using molecular dynamics simulations, and we observed the best average root mean square deviation (RMSD) of 0.99 Å for PPARG with trans-3-indoleacrylic acid, which was lower than with the native ligand BRL (2.02 Å). …”

hCDC-derived exosomes significantly decrease cardiomyocyte programed cell death and cause a trend toward increased proliferation of cardiomyocytes <i>in vitro</i> at one week in cu... by Jennifer K. Lang (344441)

Pairwise comparisons of hormonal results for DMPA-IM vs NET-EN expressed as mean percentage differences (95% CI) (mITT analysis). by Chanel Avenant (409756)

Transient VEP loss due to manipulation of the optic nerve. by Yeda Luo (710942)

“…At 15:00, the VEP decrease reached the warning criterion (50%) and a warning was issued to the surgeon who consequently altered the surgical strategy. …”

<i>N</i>⁶-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herp... by Charles R. Hesser (5147309)

“…In iSLK.219 cells the defect was linked to their roles in the post-transcriptional accumulation of the major viral lytic transactivator ORF50, which is m⁶A modified. In contrast, although the ORF50 mRNA was also m⁶A modified in KSHV infected B cells, ORF50 protein expression was instead increased upon depletion of METTL3, or, to a lesser extent, YTHDF2. …”