Image_1_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

“…Left shift of Na_V activation around a value of 5.5 mV in the thalamocortical models suppressed normal bursting of thalamocortical (TC) cells by triggering its chaotic oscillations. …”

Image_3_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

“…Left shift of Na_V activation around a value of 5.5 mV in the thalamocortical models suppressed normal bursting of thalamocortical (TC) cells by triggering its chaotic oscillations. …”

Nundorite: a geological oddity of critical minerals significance from the Mount Arrowsmith Volcanics, northwestern NSW by L. Y. Johns-Mead (18459606)

“…</p> <p>Samarium–Nd isotopic compositions of nundorite (εNd ∼+5.5 at 585 Ma) are comparable with mafic volcanic rocks of the surrounding Mount Arrowsmith Volcanics and are consistent with derivation from a mantle source. …”

Effect of dental bleaching on pulp oxygen saturation in maxillary central incisors - a randomized clinical trial by Lorena Ferreira LIMA (6673622)

Image_2_A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.tif by Jinglei Xiao (1422004)

“…Left shift of Na_V activation around a value of 5.5 mV in the thalamocortical models suppressed normal bursting of thalamocortical (TC) cells by triggering its chaotic oscillations. …”

Blocking tau phosphorylation at Ser262/356 with unphosphorylatable alanine substitutions (S2A) preferentially reduces the levels of tau_lower and partially suppresses the... by Kanae Ando (1951501)

“…Mean ± SD, n = 5; ***, <i>p</i> < 0.005 by Student's t-test. (F) Aβ42 increased the level of S2Atau in the cytosol and decreased those in the microtubule fraction, while the effects were smaller than those in wild-type tau. …”

Mucolytic Effectiveness of Tyloxapol in Chronic Obstructive Pulmonary Disease - A Double-Blind, Randomized Controlled Trial by Martin Koppitz (2838347)

“…Interestingly, there was a mean increase in all inflammatory cytokines (IL-1β, IL-6, and IL-8) during the saline treatment from day 1 to week 3, whereas during the Tyloxapol treatment, all cytokines decreased. …”

Mechanism 1: <i>N</i> > <i>T</i> > <i>E</i> for a small nucleus. by Ondrej Maxian (8722185)

“…The behavior is qualitatively more similar to the <i>T</i> > <i>N</i> > <i>E</i> regime shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1008160#pcbi.1008160.s006" target="_blank">S5 Fig</a>. …”

Image_2_Volcanic Record of the Last Geomagnetic Reversal in a Lava Flow Sequence From the Azores.TIFf by Julia Ricci (8938412)

“…The reversal is characterized by weak field intensity during the transition, a recovery phase and a subsequent decrease during the rebound. …”

Image_1_Volcanic Record of the Last Geomagnetic Reversal in a Lava Flow Sequence From the Azores.tiff by Julia Ricci (8938412)

“…The reversal is characterized by weak field intensity during the transition, a recovery phase and a subsequent decrease during the rebound. …”

A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome by Anna Tarradas (105463)

“…Sodium currents were studied using standard whole cell patch-clamp protocols and immunodetection experiments were performed using an antibody against human Na_v1.5 channel. A marked decrease in current density was observed in cells expressing the I890T channel (from −52.0±6.5 pA/pF, <em>n</em> = 15 to −35.9±3.4 pA/pF, <em>n</em> = 22, at −20 mV, WT and I890T, respectively). …”

Promoting the Spreading of Droplets on a Superhydrophobic Surface by Supramolecular Amphiphilic Complex-Based Host–Guest Chemistry by Pei Liu (93392)

“…Herein, we report an approach to fabricate a supramolecular amphiphilic system that significantly contributes to this issue. …”

Promoting the Spreading of Droplets on a Superhydrophobic Surface by Supramolecular Amphiphilic Complex-Based Host–Guest Chemistry by Pei Liu (93392)

“…Herein, we report an approach to fabricate a supramolecular amphiphilic system that significantly contributes to this issue. …”

A Meta-Analysis of <em>Caspase 9</em> Polymorphisms in Promoter and Exon Sequence on Cancer Susceptibility by Wei Xu (28953)

“…Through the stratified analysis, statistically significant reduced cancer risks were observed among Caucasians (AG <em>vs</em> AA: OR = 0.81, 95% CI = 0.66–0.99, <em>P</em>_{heterogeneity} = 0.150 and the dominant model: OR = 0.86, 95% CI = 0.75–0.99, <em>P</em>_{heterogeneity} = 0.290) and prostate cancer. As for rs105276, Ex5+32G>A polymorphism was found with protective effect in overall meta-analysis (AA <em>vs</em> GG: OR = 0.75, 95% CI = 0.60–0.92, <em>P</em>_{heterogeneity} = 0.887; A <em>vs</em> G: OR = 0.85, 95% CI = 0.77–0.95, <em>P</em>_{heterogeneity} = 0.739 and the recessive model: OR = 0.68, 95% CI = 0.56–0.82, <em>P</em>_{heterogeneity} = 0.309) and Asians group. …”

History dependence disentangles the effects of input activation, reactivation and temporal depth of a binary autoregressive process. by Lucas Rudelt (4059505)

“…<p>(A) In the binary autoregressive process, the state of the next time step (grey box) is active (one) either because of an input activation with probability <i>h</i>, or because of an internal reactivation. …”

Table_1_Ventricular Myocardial Deformation in Fetuses With Tetralogy of Fallot: A Necessary Field of Investigation.DOCX by Xiaoyan Song (2887361)

“…This study aimed to assess biventricular myocardial deformations in fetuses with TOF compared with normal fetuses.</p><p>Methods: A retrospective cohort study of fetuses with TOF and gestational age (GA)-matched controls was conducted at a single tertiary referral center from 2014 to 2020. …”

The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge by Josefin Söder (4183498)

“…Twenty-eight healthy intact male Labrador Retrievers were included, 12 of which were classified as lean (body condition score (BCS) 4–5 on a 9-point scale) and 16 as overweight (BCS 6–8). …”

Effects of health risk assessment and counselling on physical activity in older people: A pragmatic randomised trial by Anna Marie Herghelegiu (4262071)

“…In the control group, PA decreased by a median of 346.5 MET minutes per week (95% CI 178.4–514.6, p<0.001) to 693.0 MET minutes per week due to a seasonal effect, resulting in a difference of 420.0 MET minutes per week (95% CI 212.7–627.3, p< 0.001) between groups.…”

LRP1 mediates internalization and accumulation of Aβ42 in GT1-7 and MEF cells. by Rodrigo A. Fuentealba (362971)

“…<p><i>A,</i> LRP1 knockdown decreases Aβ42 accumulation in GT1-7 cells. …”

Dopamine signals are coupled to the activation of Akt and inactivation of GSK3β in hippocampal neurons (A–D). by Sigeng Chen (248428)

“…<p>A. Western blot analysis shows that treatment with dopamine (30 nM) for 60 minutes leads to the inactivation of Akt (i.e., decreased serine-473 phosphorylation) and the activation of GSK3β (i.e., decreased serine-9 phosphorylation). …”