Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…Neuronal nitric oxide synthase (nNOS) inhibition is a promising strategy to treat neurodegenerative disorders, but the development of nNOS inhibitors is often hindered by poor pharmacokinetics. We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

Relative <i>APOBEC3A</i> and MeV <i>M</i> mRNA quantification upon MeV infections in cells stably expressing DNase I. by Pierre Khalfi (7868252)

Predator phylogenetic diversity decreases predation rate via antagonistic interactions by Andrew MacDonald (421949)

The Type 2 Diabetes Risk Allele of <i>TMEM154</i>-rs6813195 Associates with Decreased Beta Cell Function in a Study of 6,486 Danes by Marie Neergaard Harder (232759)

“…Significant associations between <i>TMEM154</i>-rs6813195 and the beta cell measures insulinogenic index and disposition index and between <i>FAF1</i>-rs17106184 and 2-hour serum insulin levels were selected for further investigation in additional Danish studies and results were combined in meta-analyses including up to 6,486 Danes.</p><p>Results</p><p>We confirmed associations with type 2 diabetes for five of the seven SNPs (<i>TMEM154</i>-rs6813195, <i>FAF1</i>-rs17106184, <i>POU5F1/TCF19</i>-rs3130501, <i>ARL15</i>-rs702634 and <i>ABCB9/MPHOSPH9</i>-rs4275659). …”

Supplementary Material for: Mitochondrial Polymorphisms Are Associated Both with Increased and Decreased Longevity by Castri L. (4119472)

Ether Cleavage Decreases the Ion Exchange Capacity of Anion Exchange Membranes by Shakkira Erimban (6882539)

Ether Cleavage Decreases the Ion Exchange Capacity of Anion Exchange Membranes by Shakkira Erimban (6882539)

The G357S mutation decreases both activation and termination thresholds for SOICR. by Yingjie Liu (317210)

Error Decreases with More Valid Edges Provided as Existing Network Information. by Scott Christley (40869)

Root Mean Square Error (RMSE) decreases with number of structures used. by Samuel Coulbourn Flores (11636717)

Dataset from Relatedness decreases and reciprocity increases cooperation in Norway rats by Manon K. Schweinfurth (4859590)

Visual steady state in relation to age and cognitive function by Anna Horwitz (771335)

“…We find that Δ<i>R</i>_<i>V</i> decrease with age by just over one standard deviation when comparing young with old participants (<i>p</i><0.01). …”

Decreased vagal activity and deviation in sympathetic activity precedes development of diabetes by Da Young Lee (8617365)

Decreased uric acid levels in the acute phase of Plasmodium vivax malaria by Luciano Teixeira Gomes (638367)

CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis by A. Nonino (6072632)

Glucagon resistance and decreased susceptibility to diabetes in a model of chronic hyperglucagonemia by Nadejda Bozadjieva Kramer (9657179)

Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia by Yiting Zhang (391974)

“…Vitamin B₁₂ (cobalamin, Cbl) exists in multiple forms, including methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), serving as cofactors for MS and methylmalonylCoA mutase, respectively. We measured levels of five Cbl species in postmortem human frontal cortex of 43 control subjects, from 19 weeks of fetal development through 80 years of age, and 12 autistic and 9 schizophrenic subjects. …”

Results of comparison between Model5 and Model9. by Taiga Mori (21410076)

Results of comparison between Model5 and Model10. by Taiga Mori (21410076)

Image_1_Impact of inactivated vaccines on decrease of viral RNA levels in individuals with the SARS-CoV-2 Omicron (BA.2) variant: A retrospective cohort study in Shanghai, China.ti... by Peng Yang (296696)

“…We performed the survival data analysis and Generalized Estimating Equation to calculate the adjusted relative risk (aRR) to assess the effect of inactivated vaccines on the decrease of viral RNA levels.…”