Showing 1,481 - 1,500 results of 27,524 for search '(( 50 ((ppm decrease) OR (nn decrease)) ) OR ( 50 ((c decrease) OR (a decrease)) ))', query time: 0.93s Refine Results
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    Population dynamics modeling of split<sup>50cM</sup> <i>ClvR</i> V1 drive introduced at different release percentages, and an example illustrating the role that LOF alleles play in... by Georg Oberhofer (3401438)

    Published 2021
    “…(<b>G-I)</b> One way to appreciate the power of the latent drive force provided by LOF alleles that segregate independently of the <i>Rescue</i>/Cargo is to consider a split<sup>50cM</sup> <i>ClvR</i> population in which a <i>Rescue</i>/Cargo/gRNAs with no fitness cost has spread to allele fixation, the Cas9 driver chromosome has been completely eliminated (as would happen during drive if the presence of Cas9 resulted in a fitness cost to carriers, discussed below), and all endogenous copies of the essential gene have been rendered LOF (generation 0 in <b>G-I</b>). …”
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    hMSC adjunctive therapy failed to decrease pulmonary inflammation or prevent ALI compared to antiviral therapy alone in experimental severe influenza. by Ilyse Darwish (446378)

    Published 2013
    “…<p>Eight-week old male C57Bl/6 mice infected with 425 EID<sub>50</sub> influenza A/PR/8 virus were administered 2.5 mg/kg oseltamivir in 100 ul ddH2O via gavage, 1×daily for 5 days, beginning day 2 P.I., with or without hMSC administration (5×10<sup>5</sup> cells) on day 2 P.I. and sacrificed on day 7 P.I. …”
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