A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... حسب Thirumal Kumar, D

"…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …"
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A Reverse MultipleChoice Based mLearning System حسب Karkar, AbdelGhani

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The role of NF-κB and AhR transcription factors in lead-induced lung toxicity in human lung cancer A549 cells. حسب Attafi, Ibraheem M

"…The toxic effects of Pb on the lung was associated with significant increases in NF-κB and AhR levels which was accompanied with increases in downstream targets genes, iNOS and CYP1A1, respectively. …"
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Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain حسب Mohammad H., Merii

"…In addition, nicotine individually decreased expression levels of all examined protein targets, significantly for CYP1B1 (p < 0.001), CYP19A1 (p = 0.010), AhRR (p = 0.042), and ARNT (p < 0.001), compared to control. …"
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Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts. حسب Ardah, Mustafa T

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Microwave-Assisted Solvothermal Synthesis of Mo-Doped TiO2 with Exceptional Textural Properties and Superior Adsorption Kinetics حسب Ahmad, Yahia H.

"…The average particle size ranged between 9.7 and 27.5 nm and it decreased with increasing the Mo content. Furthermore, Mo-TiO2 revealed mesoporous architectures with a high surface area ranging between 170 and 260 m2 g−1, which is superior compared to previously reported Mo-doped TiO2. …"
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Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach حسب P., Sneha

"…Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. …"
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The Cellular Interplay Between Na+/H+ Exchanger Isoform I and Osteopontin in Cardiac Hypertrophy حسب Abdelaziz, Iman Ahmed

"…OPN appeared to contribute to NHE1-induced CH independent of extracellular-signal-regulated kinases, p90-ribosomal-S6 kinase and protein kinase B (Akt). …"
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Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs حسب Salloum-Asfar, Salam

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Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells. حسب Al-Jaber, Hend

"…Other insulin resistance-related phospho-proteins (GSK3B, mTOR, PTEN) increased with IL-6, 4HNE, TNFα, and high insulin under hypoxia, while p-IRS1 levels remained unaffected. …"
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Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats حسب Kiss, K.

"…In study 4, AF43136 at 10 mg/kg decreased infarct size, similarly to the positive control CsA compared to the appropriate vehicle (39.4 ± 5.9% vs. 58.1 ± 5.4% and 45.9 ± 2.4% vs. 63.8 ± 4.1%, p < 0.05, respectively). …"
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Surface Roughness Modelling of the Micromechanically Patterned CNT Forests حسب Mohd Razib , Mohd Asyraf

"…Introduction: A new method of modelling surface roughness of the resultant structure from various parameters in the microforming of CNT forests has been developed. One of the top-down microforming methods of CNT forests is called micromechanical bending (M2B). …"
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Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model. حسب Jabri, Tooba

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Synthesis of Metallocene Catalyzed Ethylene 1,7-Octadiene Copolymer: Effect of Copolymerization on Polymer Properties حسب Rahaman M.

"…In this article, metallocene catalyzed polyethylene homopolymer and ethylene 1,7-octadiene copolymers were synthesized and the produced polymers were characterized. …"
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Study of Magnetic Properties and Lattice Dynamics of the Cdx Co1-x Ferrite System by MossbauerEffect حسب Eissa, N. A. [نبيل عيسى]

"…The Neel temperature was found to decrease with increasing cadmium concentration. The reduced hyperfine magnetic fields for the A- and the B- sites were found to follow the Brillouin function and One-Third-Power Law. …"
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Vitamin K1 as a potential molecule for reducing single-walled carbon nanotubes-stimulated �-synuclein structural changes and cytotoxicity حسب Naskhi A.

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Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update حسب Smatti, Maria K.

"…Further sub genotyping can be characterized by analyzing the LMP-1 gene variation. The virus primarily transmits through oral secretions and persists as a latent infection in human B-cells. …"
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Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Produc... حسب Al Dhaheri, Yusra

"…Further investigation revealed that O. majorana suppresses the phosphorylation of IκB, downregulates the nuclear level of NFκB and reduces Nitric Oxide (NO) production in MDA-MB-231 cells. …"
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Genotoxic impact of long-term cigarette and waterpipe smoking on DNA damage and oxidative stress in healthy subjects حسب Alsaad A.M.

"…This was associated with a marked decrease (50%) in the expression of detoxifying genes (NQO1 and GSTA1) with an increase in CYP1A1 mRNA expression, a cancer-activating gene. …"
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Mossbauer Effect Study of the Cations Distribution and its Influence on the Electric Field Gradient of the Cdx Co1-x Ferrite System حسب Eissa, N. A. [نبيل عيسى]

"…In the ferrite system Cd,Co,_x Fe; 04 (X=0.0, O.I, 0.2, ....... , 1.0). it was found that the introduction of Co2'1' decrease the EFG at the octahedral B-site. …"
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