-
101
Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy .
منشور في 2020"…Compared with control, we found in STZ-rats with established pain hypersensitivity (5 weeks post-STZ) several significant changes including: (a) A 23% increase in the incidence of spontaneous activity (SA) in Aβ-LTMs (but not C-mechanosensitive nociceptors) that may cause dysesthesias/paresthesia suffered by DPNP patients, (b) membrane hyperpolarization and a ∼85% reduction in SA rate in Aβ-LTMs by K7 channel activation with retigabine (6 mg/kg, i.v.) suggesting that K7/M channels may be involved in mechanisms of SA generation in Aβ-LTMs, (c) decreases in AP duration and in duration and amplitude of afterhyperpolarization (AHP) in C-and/or Aβ-nociceptors. …"
احصل على النص الكامل
احصل على النص الكامل
-
102
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
منشور في 2018"…The D-2-HGA includes two subtypes: type I and type II caused by the mutations in D2HGDH and IDH2 proteins, respectively. In this study, we studied six mutations, four in the D2HGDH (I147S, D375Y, N439D, and V444A) and two in the IDH2 proteins (R140G, R140Q). …"
احصل على النص الكامل
احصل على النص الكامل
-
103
-
104
-
105
-
106
-
107
Qatar Culture Collection of Microalgae: A Sustainable Source for Biodiesel Production and Omega Fatty Acid Compounds
منشور في 2016"…The good growth rate of these strains along with their lipid content and profile make them competitive for a viable algal biofuel technology comparing to the terrestrial oil crops which need longer time to grow and present lower amount of lipids (Weyer et al., 2010). In addition, we observed the presence of the omega-3 and 9 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic (EPA, 20:5 n-3), docosahexaenoic (DHA, 22:6 n-3) and Nervonic Acid (C24:1 n-9) acids, which have a high commercial value and are known for their beneficial effects on human health…"
احصل على النص الكامل
احصل على النص الكامل
-
108
Changing Trends in the Referral and Timing of Treatment for Congenital Cryptorchidism: A Single-Center Experience from Bosnia and Herzegovina.
منشور في 2019"…The analysis of the observed two periods (2008-2010 and 2015-2017) showed a statistically significant decrease in the mean referral age and the mean age at surgery over the last 5 years (2015-2017) (p = 0.007 and p = 0.003, respectively). …"
احصل على النص الكامل
احصل على النص الكامل
-
109
Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
منشور في 2019"…Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. …"
احصل على النص الكامل
احصل على النص الكامل
-
110
-
111
Climatology and variability of wind speeds along the southwest coast of India derived from Climate Forecast System Reanalysis winds
منشور في 2022"…The study reveals significant decreasing trends in annual mean wind speeds, of the order of −2.0 to −2.5 cm·s−1·year−1, for the period 1979–2019. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
-
112
Integrated planning of spare parts and service engineers with partial backlogging
منشور في 2017"…In a numerical study, we show that for problems with more than five types of spare parts it is preferable to use approximate evaluations as they become significantly faster than exact evaluation. …"
احصل على النص الكامل
احصل على النص الكامل
-
113
-
114
Estimating and decomposing changes in the White–Black homeownership gap from 2005 to 2011
منشور في 2015"…In fact, we find that the gap decreased for households that were the least likely to own and remained unchanged for households that were the most likely to own, and that Black households with around a 50% probability of homeownership were especially vulnerable to the crisis. …"
احصل على النص الكامل
احصل على النص الكامل
-
115
-
116
-
117
-
118
-
119
Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein inter...
منشور في 2022"…From the analysis, we observed the highest deviation with lowest compactness and a decrease in the intramolecular h-bonds in the BRCA1-BARD1 protein complex with the V11G mutation compared to the native complex or the complexes with other mutations. 2022 Elsevier Inc.…"
احصل على النص الكامل
احصل على النص الكامل
-
120
Evaluating the impact of price regulation (Drug Price Control Order 2013) on antibiotic sales in India: a quasi-experimental analysis, 2008–2018
منشور في 2022"…The primary outcome measure is the percentage change (increase or decrease) in the sales volume of the antibiotics under DPCO 2013, measured in standard units (SUs). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل