Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors by Vincenzo Cantaluppi (92814)

“…In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. …”

Machine learning models and univariate analyses discriminating non-severe and severe COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Machine learning models and univariate analyses discriminating HC from non-severe COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Machine learning models and univariate analyses discriminating severe and critical COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger - Fig 2 by Andrea Szentesi (3239193)

IFN-γ counter-regulates hepatic fetuin-A expression. by Wei Li (7081)

“…<p><b>A</b>). <i>IFN-γ decreased fetuin-A expression levels in hepatocytes</i>. …”

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles <i>in vitro</i> - Fig 4 by Remo Campiche (3714208)

“…Hair follicles treated with lower concentrations of Gambogic Amide kept their anagen-like appearance. Bars = 50 μm. <b>E: Immunohistochemical quantification of melanocytes with p16, a marker for mature and senescent melanocytes</b>. …”

Overlayed expression profiles of cyclins A2 and B1. by James W. Jacobberger (184625)

LTP modulates steady-state inactivation of A-type K⁺ currents. by Sung-Cherl Jung (261358)

“…Scale bars, 200 pA, 50 ms. The A-current available for activation at −60 mV was significantly decreased only in the neurons receiving paired stimulation 10 min after conditioning stimulation (a red arrow). …”

Elution profile of PC-Sepharose and SDSPAGE analysis. by Rafael I. Monsalve (2948826)

“…The SDSPAGE in the inset shows the proteins separated in these steps: Lane 1 corresponds to the initial extract, lane 2 corresponds to the FT, and lane 3 to the Vesp v 1 peak. …”

Box plot displaying the distributions of the deconvolution derived proportions of cell types. by Arttu Autio-Kimura (20454681)

Fig 3 - by Belinda Kweka (9931483)

“…Compared to those without G6PD deficiency, heterozygous females had decreased odds of PD/DM diagnosis (adjusted OR 0.47, 95% CI: 0.22, 0.99, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0244782#pone.0244782.t003" target="_blank">Table 3</a>). …”

A Decomposition analysis of iNTS change in incidence by SDI, 1990 to 2021. Fig 6B. SDI-related health inequality regression for the incidence rate of iNTS worldwide, 1990 and 2021. by Yunjuan He (7107446)

Structural Alterations of the “Address” Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity by Hongguang Ma (5105198)

Baseline characteristics of study participants by presence of the metabolic syndrome. by Hui Song (53547)

Grand average ABR waveforms (N = 8) prior to (black) and following (red) SS-induced tinnitus and elicited by the second 70 dB SPL noise burst (NB2) following a 50 ms silent gap. NB... by Andrea S. Lowe (693855)

Daily and annual fractional global area with rainfall from the ERA5 reanalysis. by Rasmus E. Benestad (12530330)

“…<p>The blue curve represents the rainfall area between 50°S and 50°N. The thick curves show the annual mean <i>A</i>_<i>p</i> estimated from daily estimates. …”

Effects of oxidative stress. by Kazunari Ozasa (1959577)

“…At a higher H₂O₂ (TEMPOL) concentration of 1.0 mM (50 mM), the swimming activity of the cells was decreased dramatically. …”

Modification of intracellular ROS level abrogates eltrombopag’s effect on AML cells. by Anna Kalota (7415)