Enzyme Active Site Loop Revealed as a Gatekeeper for Cofactor Flip by Targeted Molecular Dynamics Simulations and FRET-Based Kinetics by Sophie Rahuel-Clermont (6235601)

“…To monitor cofactor movements within the active site, we used an intrinsic fluorescence resonance energy transfer signal between Trp177 and the reduced nicotinamide moiety to kinetically track the flip during the catalytic cycle of retinal dehydrogenase 2 (ALDH1A2). Decreasing loop flexibility by substituting Ala for Gly271 drastically reduced the rate constant associated with this movement that became rate-limiting. …”

Understanding the Reactivity, Selectivity, and Deactivation of Frustrated Lewis Pairs for Semihydrogenation of Acetylene by Jingyun Ye (1289649)

“…The catalytic cycle consists of three steps: (1) alkyne insertion, (2) H₂ heterolysis, and (3) intramolecular protonation. …”

Understanding the Reactivity, Selectivity, and Deactivation of Frustrated Lewis Pairs for Semihydrogenation of Acetylene by Jingyun Ye (1289649)

“…The catalytic cycle consists of three steps: (1) alkyne insertion, (2) H₂ heterolysis, and (3) intramolecular protonation. …”

Propensity-score matched open aortic group. by Tomi Obafemi (12328433)

“…There was a decrease in post-op LOS, post-op VAP, and post-op UTI, although statistical significance was not attained.…”

Pre-match CABG/Valve group. by Tomi Obafemi (12328433)

“…There was a decrease in post-op LOS, post-op VAP, and post-op UTI, although statistical significance was not attained.…”

Propensity-score matched CABG/Valve group. by Tomi Obafemi (12328433)

“…There was a decrease in post-op LOS, post-op VAP, and post-op UTI, although statistical significance was not attained.…”

Quantification of cell apoptosis and survival by flow cytometry in CsA-treated HK-2 cells: Effect of GADD45G knockdown. by Gyu-Tae Shin (5819249)

Pelvis and femur shape prediction using principal component analysis for body model on seat comfort assessment. Impact on the prediction of the used palpable anatomical landmarks a... by Léo Savonnet (7314200)

“…Results also show that the PCA based method is a good alternative to predict hip and lumbosacral joint centers with an average error of 5.0 and 9.2 mm respectively.…”

A priori model predictions. by Adam M. Roth (19845864)

Video_1_Autologous Fractionated Adipose Tissue as a Natural Biomaterial and Novel One-Step Stem Cell Therapy for Repairing Articular Cartilage Defects.MP4 by Qi Li (67548)

Cystinosin half-life estimation in a human proximal tubule (HK-2) cell line. by Emma J. Brasell (8081969)

Time course of body weight (A) and cumulative food intake (B). by Toru Kuriyama (16631992)

The <i>Kdm6a</i>-null stroma promotes the expression of <i>Kdm6a-</i>null hematopoietic stem and progenitor cells. by Ling Tian (107492)

The AzEvC10 mutant upregulates virulence factor expression before metabolic gene expression during macrophage infection. by Mylene Vaillancourt (7409486)

Lipophilic atorvastatin is more effective at suppressing cancer cell growth than hydrophilic rosuvastatin or pravastatin. by Colin H. Beckwitt (2037196)

Effects of Y-P30 on expression and phosphorylation of glutamate receptors, Src, and ERK. by Janine R. Neumann (6330863)

“…(A) Representative blot at DIV 20; per lane, 50% of a lysate from a vehicle-treated control and a 60 min Y-P30-treated OTC was loaded on the left and the right side of a gel. …”

Seventy Years of Asthma in Italy: Age, Period and Cohort Effects on Incidence and Remission of Self-Reported Asthma from 1940 to 2010 by Giancarlo Pesce (184046)

“…</p><p>Conclusions</p><p>After 50 years of a continuous upward trend, the rates of asthma incidence underwent a substantial stabilization in the late 90s. …”

Y-P30 does not alter somatodendritic differentiation of cortical neurons but promotes filopodia pruning and morphological maturation of spines on pyramidal neurons. by Janine R. Neumann (6330863)

“…(D) Y-P30 did not alter the density of interneuronal (IN) dendritic protrusions and basal dendritic protrusions of pyramidal cells (PC) at DIV 10 (treated with 1 μM Y-P30 at DIV 7 and DIV 9) and DIV 20 (daily one pulse of 1 μM Y-P30 from DIV 15–19). Plotted is the mean number ± SEM per 100 μm dendritic length. (E) Y-P30 decreased the density of protrusions on secondary oblique branches from the apical dendrites of pyramidal cells at DIV 10 by 27% and at DIV 20 by 13%. …”

Wnt mediates hSVF vascular self-assembly. by Venkat M. Ramakrishnan (2559520)

“…<p><b>(A)</b> The CCK-8 cell cytotoxicity assay demonstrated that IWP2 concentrations ≤ 25μM were not cytotoxic, whereas 50μM was cytotoxic (***<i>p</i> ≤ 0.001). …”

Immunostaining of the membrane of PC3 cells after treatment with [Alexa594]—(Cys⁰) -DRS-B2. by Célia Dos Santos (306471)