Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci by Dennis J. Hazelett (517336)

“…To aid the identification of these enhancers, we performed genomewide ChIP-seq for H3K27-acetylation, a mark of actively engaged enhancers, as well as the transcription factor TCF7L2. We analyzed in depth three variants in risk enhancers, two of which show significantly altered androgen sensitivity in LNCaP cells. …”

General Methodology to Optimize Damping Functions to Account for Charge Penetration Effects in Electrostatic Calculations Using Multicentered Multipolar Expansions by Araken S. Werneck (2458621)

“…This methodology is based in the optimization of a damping parameter set using a two-step fast local fitting procedure and the ab initio (Hartree−Fock/6-31G** and 6-31G**+) electrostatic potential calculated in a set of concentric grid of points as reference. …”

The Deoxyhypusine Synthase Mutant <i>dys1-1</i> Reveals the Association of eIF5A and Asc1 with Cell Wall Integrity by Fabio Carrilho Galvão (396804)

“…In this study, we generated and characterized the <i>dys1-1</i> mutant, which showed a strong depletion of mutated Dys1 protein, resulting in more than 2-fold decrease in hypusine levels relative to the wild type. …”

Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents by Yini Wang (410389)

“…<div><p>A new acridone derivative, 2-aminoacetamido-10-(3, 5-dimethoxy)-benzyl-9(10H)-acridone hydrochloride (named 8a) synthesized in our lab shows potent antitumor activity, but the mechanism of action remains unclear. …”

Representative images of cecum and ileum histology. by Jason R. Devlin (7320236)

Table 7_Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain.xlsx by Saeideh Aran (20601371)

Hydrodynamic Treadmill Reveals Reduced Rising Speeds of Oil Droplets Deformed by Marine Bacteria by Vincent Hickl (16947429)

Image_1_Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functi... by Gabriele Dupont (13581157)

“…<p>In the last two decades, there has been a growing body of research that identified sex-related differences in attention-deficit hyperactivity disorder (ADHD). …”

Image_3_Sex-related differences in adult attention-deficit hyperactivity disorder patients – An analysis of external globus pallidus functional connectivity in resting-state functi... by Gabriele Dupont (13581157)

“…<p>In the last two decades, there has been a growing body of research that identified sex-related differences in attention-deficit hyperactivity disorder (ADHD). …”

Supplementary Material for: Selective Serotonin Reuptake Inhibitors and Serotonin Noradrenaline Reuptake Inhibitors withdrawal changes DSM presentation of mental disorders: Results... by Cosci F. (4134769)

“…Using a new nosographic classification of withdrawal syndromes due to SSRI/SNRI decrease or discontinuation (by Chouinard and colleagues), we explored whether DSM is adequate to identify DSM disorders when withdrawal occurs. …”

KatN is crucial for the survival of EHEC in macrophages. by Baoshan Wan (3833551)

“…<p>(A) The intracellular survival of the WT, Δ<i>katN</i> and Δ<i>katN-</i>c in RAW264.7 macrophages. …”

UTX-1 is required for VPA action in <i>C. elegans</i> embryos and in human cells. by Rakel Brendsdal Forthun (121022)

“…Numbers shown are arbitrary units compared to negative control siRNA. The blot shows a 60% decrease in UTX by siRNA treatment, confirming the efficacy of transfection. …”

DataSheet1_Evaluation of the immune response of peripheral blood mononuclear cells cultured on Ti6Al4V-ELI polished or etched surfaces.pdf by Hugo Abreu (19815654)

“…</p>Discussion<p>The dysregulation of the cytokine profile upon contact with untreated Ti6Al4V-ELI discs, namely upregulation of IL-2 could be responsible for the decrease in Th17 frequency, and thus might contribute to implant-associated bacterial infection. …”

Data_Sheet_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Table_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Data_Sheet_3_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Gene-gene interaction network underlying LRO accumulation of Nile red and autofluorescence. by Alexander A. Soukas (476353)

“…(F) RNAi to acyl-coenzyme A synthetase <i>acs-6</i> increases blue autofluorescence in a manner genetically dependent upon TOR complex 2 mutant <i>rict-1</i>. (C–F, N as in table S3 and S4; significance by unequal variance, two-tailed Student's t-test with Bonferroni step-down correction.)…”

Image_1_Genome-Wide Expression Analysis of Glyoxalase I Genes Under Hyperosmotic Stress and Existence of a Stress-Responsive Mitochondrial Glyoxalase I Activity in Durum Wheat (Tri... by Mario Soccio (12961406)

“…Expression profile by qRT-PCR analysis revealed that most of the putative active TdGLYI genes were up-regulated by salt and osmotic stress in roots and shoots from 4-day-old seedlings, although a different behavior was observed between the two types of stress and tissue. Accordingly, in the same tissues, hyperosmotic stress induced an increase (up to about 40%) of both GLYI activity and MG content as well as a decrease of GSH (up to about –60%) and an increase of GSSG content (up to about 7-fold) with a consequent strong decrease of the GSH/GSSG ratio (up to about –95%). …”

Proxy-based paleoclimate series for the last 5000 years. by David Kaniewski (218243)

“…Positive scores correspond to higher humidity whereas negative scores indicate dry periods <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Kaniewski1" target="_blank">[11]</a>; (<b>c</b>) Time-series (5000 BP to present by step of 100 years) of annual precipitation (anomalies from the present in mm/yr) averaged on Southeastern Mediterranean region (longitude 20°E−50°E, latitude 30°N-45°N); the data are reconstructed from pollen data extracted from the European Pollen Database; (<b>d</b>) fluctuations in Nile floods, indicated by lake level variations of Lake Qarun (Fayum depression, Egypt) inferred from paleoshorelines and lake sediments <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Hassan2" target="_blank">[73]</a>; (<b>e</b>) reconstruction of annual precipitation based on botanical-climatological transfer functions applied to pollen data from Ain Gedi sediments (Dead Sea shore) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Litt1" target="_blank">[15]</a>; (<b>f</b>) Abundance of Cyperaceae pollen, a marker of fresh water input, in a sediment core from Burullus Lagoon in the north-central Nile Delta <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Bernhardt1" target="_blank">[14]</a>. …”

Secondary screening and ‘hit’ validation. by Ilona Tkachyova (343715)

“…Distinct decrease in <i>NDST1</i> expression was observed for 2x IC₅₀ SAHA treatment. …”