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Datasheet1_Acquired von Willebrand syndrome (AVWS) type 2, characterized by decreased high molecular weight multimers, is common in children with severe pulmonary hypertension (PH)...
Published 2022“…All but one of the 14 children with severe PH had a coagulation disorder. Most patients (9 proven, 2 suspected) had AVWS type 2. …”
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In <i>Drosophila</i> DSK and TO inhibits Gr64f gene transcription and optogenetic activation of Dsk-GAL4 neurons decreases the sensitivity of gustatory neurons in starved flies.
Published 2021“…(<b>F</b>) Expression pattern of <i>Dsk</i>-GAL4 in the brain revealed by anti-GFP (F1) and anti-DSK (F2). Scale bars, 50 μm. (<b>G</b>) Electrophysiological recordings reveal that starved flies (24 h) show increased sensitivity of GRNs compared with refed flies (fed 1.5 h after starvation) and optogenetic activation of <i>Dsk</i>-GAL4 neurons (30 min) decreases the sensitivity of gustatory neurons in starved flies (24 h). …”
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Establishing short-term occupational exposure limits (STELs) for sensory irritants using predictive and <i>in silico</i> respiratory rate depression (RD<sub>50</sub>) models
Published 2024“…Schaper <a href="#CIT0049" target="_blank">1993</a> described a significant relationship with high correlation between the measured exposure concentration producing a 50% respiratory rate decrease (RD<sub>50</sub>) in a standard rodent assay and the American Conference of Governmental Industrial Hygienists (ACGIH®) Threshold Limit Values (TLVs®) as time-weighted averages (TWAs) for airborne chemical irritants. …”
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Data_Sheet_1_Wildtype peers rescue social play and 50-kHz ultrasonic vocalization deficits in juvenile female Cacna1c heterozygous rats.docx
Published 2023“…Same-genotype HET pairs played less and emitted fewer 50-kHz USV than same-genotype WT or opposite-genotype pairs; however, we found that the decrease in social play and 50-kHz USV in HET pairs can be rescued by playing with a WT partner. …”
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