Hit expansion around chloroxine. by Sam Barker (4832121)

“…This modification causes a significant decrease in this compound’s activity as a co-treatment with ceftazidime, with a <i>p</i>IC50 ≈ 3.4. 5,7-dichloro-2-methyl-8-quinolinol differs from chloroxine by addition of a methyl group in the 2-position (B). …”

Effect of BC-819 on cell growth in different lung cancer cell lines. by Günther Hasenpusch (350166)

“…The influence of BC-819 on bioluminescent A549-C8-luc was examined as well and revealed decreased luciferase and therefore reduced cell growth (more than 50%) as early as after 24 hours (C). …”

Dissociation, and not specific actions of Trypsin-EDTA, acts to suppress neurectoderm formation. by James N. Hughes (319868)

“…Error bars represent sem. (a) denotes a decrease compared to MEDII⁻/Dissociation⁻ where p<0.01. …”

Long-term growth curves of nucleus pulposus chondrocytes (NPCs) obtained from donors of various ages. by Jun-Seok Lee (181420)

“…<p>Plots of cumulative population doubling levels (PDLs) against time in culture (A) and passage number (B). The cumulative PDLs of NPCs from the young group (patients in their 30s, 40s, and 50s) were relatively higher than those from the old group (patients in their 60s and 70s). …”

The reduced expression of ZBRK1 is inversely correlated with the increased expression of KAP1 in cervical cancer specimens. by Li-Fang Lin (449199)

“…<p><b>A</b>, All tumor specimens from 50 patients with different stages of cervical cancer were obtained from surgically resected tissues. …”

Heme Oxygenase Isoform 1 Regresses Cardiomyocyte Hypertrophy Through Regressing Sodium Proton Exchanger Isoform 1 Activity by Sobh, Ahmed

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Training at maximal power in resisted sprinting: Optimal load determination methodology and pilot results in team sport athletes by Matt R. Cross (5089268)

“…<div><p>Aims</p><p>In the current study we investigated the effects of resisted sprint training on sprinting performance and underlying mechanical parameters (force-velocity-power profile) based on two different training protocols: (i) loads that represented maximum power output (<i>L</i>_opt) and a 50% decrease in maximum unresisted sprinting velocity and (ii) lighter loads that represented a 10% decrease in maximum unresisted sprinting velocity, as drawn from previous research (<i>L</i>₁₀).…”

DataSheet1_Interaction of Serum Alkaline Phosphatase and Folic Acid Treatment on Chronic Kidney Disease Progression in Treated Hypertensive Adults.docx by Yuanyuan Zhang (101797)

“…The primary outcome was CKD progression, defined as a decrease in estimated glomerular filtration rate (eGFR) of ≥30% and to a level of <60 ml/min/1.73 m² if baseline eGFR was ≥60 ml/min/1.73 m²; or a decrease in eGFR of ≥50% if baseline eGFR was <60 ml/min/1.73 m²; or end-stage renal disease. …”

Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments by Céline Portal (3876436)

“…Ten days of BAK in one eye followed by 4 days without any treatment induced a −18.3% decrease in conjunctival goblet cell density. …”

Difference in GHG emissions (<em>x</em>-axis) and food availability (<em>y</em>-axis) in 2050 for the different scenarios with respect to 'TREND' by H Valin (557174)

“…</strong> Difference in GHG emissions (<em>x</em>-axis) and food availability (<em>y</em>-axis) in 2050 for the different scenarios with respect to 'TREND'. Panels (A)–(C) and (D) delineate domains where food provision increases ((A), (B)) or decreases ((C), (D)) and GHG emission savings increase ((B), (D)) or decrease ((A), (C)). …”

Data_Sheet_1_Effect of Lockdown Amid COVID-19 on Ambient Air Quality in 16 Indian Cities.docx by Amit Kumar Mishra (5644676)

“…SO₂ and O₃ showed an increase over a few cities as well as a decrease over the other cities. …”

Cardiac chambers undergo regionalised reduction in cell size. by Juliana Sánchez-Posada (20636677)

“…<p>(A–D) Quantification of internuclear cardiomyocyte distance as a proxy for cell size reveals an early increase in atrial cardiomyocyte size and a later reduction in ventricular cardiomyocyte size. …”

Renal phenotype of male Akita mice by genetic background. by Jae-Hyung Chang (327325)

“…<p>NR: not reported, ND: Not detected,</p>*<p>Compared to strain matched non-diabetic controls,</p>†<p>Animal models of diabetic complications consortium (ADMCC) criteria: >10-fold increase in albuminuria, >50% decrease in GFR over the lifetime of the animal, Advanced mesangial expansion, Arteriolar hylanosis, >50% increase in GBM thickness, Tubulointerstitial fibrosis,</p>**<p>variable (see text for discussion),</p>‡<p>Increased BUN at 30–40 weeks of age, References: <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Breyer1" target="_blank">[3]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Gurley1" target="_blank">[4]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Gurley2" target="_blank">[5]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Susztak1" target="_blank">[13]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Brosius1" target="_blank">[30]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Hong1" target="_blank">[35]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033942#pone.0033942-Haseyama1" target="_blank">[48]</a>.…”

Ex vivo fitness, CTL escape phenotype and sequence evolution of <i>gag</i> p24 CTL escape mutants. by Ryan M. Troyer (265934)

“…The fold escape conferred by each mutation is displayed here as the ratio of effective peptide concentration (EC₅₀) required to elicit 50% of maximal ELISpot signal relative to the pre-escape peptide <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000365#ppat.1000365-Cao2" target="_blank">[54]</a>. …”

datasheet1_Which Fault Threatens Me Most? Bridging the Gap Between Geologic Data-Providers and Seismic Risk Practitioners.pdf by Oona Scotti (5259367)

“…To illustrate the power of the methodology, in this paper we consider only one branch of the uncertainties affecting each step of the computation procedure. The resulting hazard and typological risk maps allow both data providers and end-users 1) to visualize the faults that threaten specific localities the most, 2) to appreciate the density of observations used for the computation of slip rate profiles, and 3) interrogate the degree of confidence on the fault parameters documented in the database (activity and location certainty). …”

α‑CsCu₅Se₃: Discovery of a Low-Cost Bulk Selenide with High Thermoelectric Performance by Ni Ma (676167)

“…In compariosn to the isostructural CsAg₅Te₃, α-CsCu₅Se₃ shows a 30% volume decrease that leads to stronger orbital overlapping that markedly decreases the band effective mass (<i>m</i>*). …”

α‑CsCu₅Se₃: Discovery of a Low-Cost Bulk Selenide with High Thermoelectric Performance by Ni Ma (676167)

“…In compariosn to the isostructural CsAg₅Te₃, α-CsCu₅Se₃ shows a 30% volume decrease that leads to stronger orbital overlapping that markedly decreases the band effective mass (<i>m</i>*). …”

Performance of the intact model. by Yaroslav I. Molkov (542831)

“…Note that in all diagrams in <b>B</b>, <i>α</i> was changed in both directions, first forward from 0 to 1.2 and then backward from 1.2 to 0. However, in all diagrams in Fig 3B, the graphs for forward (red) and backward (blue on the top) changes of <i>α</i> overlapped. …”

α‑CsCu₅Se₃: Discovery of a Low-Cost Bulk Selenide with High Thermoelectric Performance by Ni Ma (676167)

“…In compariosn to the isostructural CsAg₅Te₃, α-CsCu₅Se₃ shows a 30% volume decrease that leads to stronger orbital overlapping that markedly decreases the band effective mass (<i>m</i>*). …”

Data_Sheet_1_An automated heart rate-based algorithm for sleep stage classification: Validation using conventional polysomnography and an innovative wearable electrocardiogram devi... by Nicolò Pini (11370516)

“…However, most of the devices and algorithms lack extensive and independent validation, a fundamental step to ensure robustness, stability, and replicability of the results beyond the training and testing phases. …”