Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity by Valentina Noemi Madia (1585285)

“…Most of the designed derivatives were active at micromolar or submicromolar concentration, and the most promising compounds are fluorinated and/or amino acids derivatives <b>13a</b>, <b>14d</b>, and <b>15</b> that showed IC₅₀ 0.16–0.82 μM. …”

Table5_Benchmarking microbial DNA enrichment protocols from human intestinal biopsies.XLSX by Dmitrij Marchukov (15356863)

“…Additional optimization steps using further detergents and bead-beating steps improved the efficacy of less efficient protocols but not of the QIAamp kit. …”

Table5_Benchmarking microbial DNA enrichment protocols from human intestinal biopsies.XLSX by Dmitrij Marchukov (15356863)

“…Additional optimization steps using further detergents and bead-beating steps improved the efficacy of less efficient protocols but not of the QIAamp kit. …”

PPM1A is critical for proliferation of intestinal organoids. by Ruyuan Zhou (10197187)

“…A dramatic lower number of de novo crypts (D, top panel) and the decreased size of organoids (D, bottom panel) were seen in organoids from PPM1A KO mice, with roughly 50 intestine organoids each group examined. …”

Image_1_IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.TIF by Hilde L. Orrem (5740313)

“…</p><p>Results: Our main findings were (i) Tocilizumab decreased C5aR1 and C5aR2 mRNA expression significantly (p < 0.001) and substantially (>50%) at day 2 and 3, whereas C3aR expression was unaffected. …”

Image_2_IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.TIF by Hilde L. Orrem (5740313)

“…</p><p>Results: Our main findings were (i) Tocilizumab decreased C5aR1 and C5aR2 mRNA expression significantly (p < 0.001) and substantially (>50%) at day 2 and 3, whereas C3aR expression was unaffected. …”

Table_1_IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.DOCX by Hilde L. Orrem (5740313)

“…</p><p>Results: Our main findings were (i) Tocilizumab decreased C5aR1 and C5aR2 mRNA expression significantly (p < 0.001) and substantially (>50%) at day 2 and 3, whereas C3aR expression was unaffected. …”

Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction by Yuta Tsukamoto (5244005)

“…Screening showed that 5 out of 3,965 compounds inhibited ε-Pol binding, and we identified rosmarinic acid, which exhibited specificity, as a potential antiviral agent. …”

Acute knock-down of <i>Bin1</i> in the hippocampus of PS19^Hemi mice results in neuronal loss. by Kathleen M. McAvoy (7224863)

Adjusted associations between positive environment swabs and household characteristics and reported behaviors. by Sheila K. West (7245476)

Aging effects on airflow dynamics and lung function in human bronchioles by JongWon Kim (611892)

“…</p><p>Findings</p><p>The airway mechanical characteristics decreased with aging, specifically a 38% pressure drop was observed for the 80-year-old as compared to the 50-year-old. …”

Mechanistic Aspects of Horseradish Peroxidase Elucidated through Single-Molecule Studies by Hans H. Gorris (1413865)

“…Many individual horseradish peroxidase (HRP) molecules were isolated and observed simultaneously by fluorescence microscopy in an array of 50 000 femtoliter chambers chemically etched into the surface of a glass optical fiber bundle. …”

Vascular Factors and Multiple Measures of Early Brain Health: CARDIA Brain MRI Study by Lenore J. Launer (110269)

“…</p><p>Participants</p><p>A Caucasian and African-American sub-sample (n= 680; mean age 50.3 yrs) attending the 25 year follow-up exam of the Coronary Artery Risk Development in Young Adults Study.…”

Decrease in the number of macrophages and ratio of macrophage phagocytosis at the damaged site on day 4 after femoral bone defect in <i>Plg</i>^-/-and <i>uPA</i><sup>-/-<... by Naoyuki Kawao (181472)

The expression of Atpv1c1 was efficiently knocked down by AAV-sh-<i>Atp6v1c1</i>. by Sheng Li (107261)

Hepatic AMPK and Akt phosphorylation levels in mice subjected to dietary change or SD. by Mami Shiwa (712070)

Hepatic AMPK and Akt phosphorylation levels in SD- or HFD-fed mice. by Mami Shiwa (712070)

Dietary change improves weight gain, liver steatosis, glucose tolerance, and insulin resistance. by Mami Shiwa (712070)

Margins of stability. by Steven A. Thompson (22477818)