Protein and mRNA noise are inversely correlated with abundance. by Roy D. Dar (816541)

PowerPoint Slides for: Urinary Periostin Excretion Predicts Renal Outcome in IgA Nephropathy by Hwang J.H. (3300987)

“…Histologically, group 3 patients were correlated with severe interstitial fibrosis/tubular atrophy (p = 0.004), interstitial inflammation (p = 0.007), hyaline arteriolosclerosis (p = 0.001) and glomerular sclerosis (p < 0.001). A higher initial uPOSTN/Cr level was associated with a greater decline in eGFR during follow-up (p = 0.043 when initial eGFR ≥60; p = 0.025 when eGFR <60 ml/min/1.73 m2), and the renal outcomes with end-stage renal disease (ESRD; p = 0.003), ESRD and/or eGFR decrease of >30% (p = 0.033) and ESRD and/or eGFR decrease of >50% (p = 0.046) occurred significantly more in group 3. …”

Trichopsistides A and B: Two Highly Oxygenated Pentacyclic Polyketides with Promising Inhibitory Effects on the NF-κB Signaling Pathway from the Fungus <i>Trichoderma koningiopsis<... by Li Feng (77923)

“…Two highly oxygenated pentacyclic polyketides with two new carbon skeletons, trichopsistide A (<b>1</b>) and trichopsistide B (<b>2</b>), were isolated from the plant endophyte <i>Trichoderma koningiopsis</i> WZ-196 derived from the leaf of <i>Rubia podantha</i> Diels. …”

Release of HIV Gag VLPs or full HIV Virions with NL4.3 backbone were not affected on tagged CHMP4B co-expression. by Shilpa Gupta (5785598)

Identification of ALDH6A1 as a Potential Molecular Signature in Hepatocellular Carcinoma via Quantitative Profiling of the Mitochondrial Proteome by Heon Shin (4559110)

“…Surprisingly, in ALDH6A1-O/E cells, NO was decreased nearly 50% but ROS was increased at a similar level, while the former was restored by treatment with <i>S</i>-nitroso-<i>N</i>-acetyl-penicillamine. …”

Discovery of PMSA Derivative <b>11</b> as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis <i>In Vitro</i> and <i>In Vivo</i> by Zhihao Chen (513264)

“…Additionally, <b>11</b> blocked the formation of F-action belts and bone resorption in a concentration-dependent manner. Mechanistically, <b>11</b> decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation from the cytoplasm to nucleus. …”

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

Inhibition of <i>in vitro</i> and <i>in vivo</i> inflammatory responses in rats by p30A peptide. by Jérôme Rambert (46851)

“…(D) Histopathologic analysis confirm p30A ability to decrease all components of AIA lesions: pannus formation and inflammation of the synovium (P), deformity of joint and bones (asterix), bone remodeling and destruction (arrowhead), bone neoformation (arrows) and cartilage destruction.…”

Generation of CYP5122A1 half knock-outs. by Smriti Verma (204089)

“…<b>D:</b> Western blot analysis of cell lysates from WT and HKO parasites probed with anti-CYP5122A1 antibody showing decreased level of CYP5122A1 protein in the HKO parasites. …”

Effects of Cyr61 and Wnt5a on regenerating vasculature and musculature. by Devon C. Snow-Lisy (798898)

“…Scale bar, 50 μm. (Unseeded, MSC and MSC/CD34⁺ HSPC images shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138643#pone.0138643.s001" target="_blank">S1 Fig</a>).…”

Practical applications of the staining method. by Shoko Sawano (3332691)

“…Our one-step staining method succeeded in verifying the decrease in MyHC2B fibers and the increase in MyHC2X fibers in the plantaris muscles of fish oil-fed rats compared with soybean oil-fed rats. …”

Neutrophil Gelatinase Associated Lipocalin Is an Early and Accurate Biomarker of Graft Function and Tissue Regeneration in Kidney Transplantation from Extended Criteria Donors by Vincenzo Cantaluppi (92814)

“…In the non DGF group, NGAL discriminated between slow or immediate graft function and decreased more rapidly than serum creatinine. NGAL increased after Tac introduction, suggesting a role as marker of drug toxicity. …”

Table_1_Guanidine acetic acid exhibited greater growth performance in younger (13–30 kg) than in older (30–50 kg) lambs under high-concentrate feedlotting pattern.docx by Wen-Juan Li (1444948)

“…In a brief, the results obtained in the present study suggested that GAA (UGAA and CGAA; 1 g/kg DM) could be applied to improve growth performance in younger (13–30 kg) instead of older (30–50 kg) lambs in high-concentrate feedlotting practice.…”

Dietary or gavaged TU-100 and the ginger component decrease enteropooling stimulated by anti-CD3 antibody treatment in specified pathogen free (SPF) and germ free (GF) C57Bl6 mice. by Nobuhiro Ueno (346397)

Knockdown of CRT suppressed VEGF-A expression and mRNA stability through ARE in AGS cells. by Po-Chu Lee (438366)

“…VEGF-A mRNA was significantly less stable in the CRT-knockdown cells with lower half-life and 50% mRNA remaining time. …”

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger - Fig 2 by Andrea Szentesi (3239193)

Box plot displaying the distributions of the deconvolution derived proportions of cell types. by Arttu Autio-Kimura (20454681)

Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles <i>in vitro</i> - Fig 4 by Remo Campiche (3714208)

“…Hair follicles treated with lower concentrations of Gambogic Amide kept their anagen-like appearance. Bars = 50 μm. <b>E: Immunohistochemical quantification of melanocytes with p16, a marker for mature and senescent melanocytes</b>. …”

Fig 3 - by Belinda Kweka (9931483)

“…Compared to those without G6PD deficiency, heterozygous females had decreased odds of PD/DM diagnosis (adjusted OR 0.47, 95% CI: 0.22, 0.99, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0244782#pone.0244782.t003" target="_blank">Table 3</a>). …”

A Decomposition analysis of iNTS change in incidence by SDI, 1990 to 2021. Fig 6B. SDI-related health inequality regression for the incidence rate of iNTS worldwide, 1990 and 2021. by Yunjuan He (7107446)