Presentation_2_Constructing a prognostic risk model for Alzheimer’s disease based on ferroptosis.pdf by Xiao-Li Wang (182636)

“…Moreover, RT-qPCR showed that with the increase of Aβ_1–42 concentration, the expression of POR decreased first and then increased; RUFY3 was firstly increased and then decreased.…”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer by Xingchen Liu (524190)

“…In this study, we designed a series of parthenolide (PTL) derivatives through a stepwise structure optimization, and an excellent derivate <b>29e</b> showed good activity on PKM2 (AC₅₀ = 86.29 nM) and displayed significant antiproliferative activity against HT29 (IC₅₀ = 0.66 μM) and SW480 (IC₅₀ = 0.22 μM) cells. …”

An Allosteric Modulator of RNA Binding Targeting the N‑Terminal Domain of TDP-43 Yields Neuroprotective Properties by Niloufar Mollasalehi (9511076)

“…<i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. …”

Contrast modulates the cone frequency response—sum of sinusoids (SoS) stimuli. by Marcus H. C. Howlett (3921143)

Characterization of journals being listed in the DOAJ and their development over time (2011–2018). by Georg Richtig (4582933)

The conserved phenylalanine residue in PRMT5 is critical for inhibition by the five compounds. by Gui-Mei Kong (4353751)

“…D, The F225M mutation in PRMT5 decreased the IC₅₀ values of the compounds, as determined by quantitation and analysis of methylation assay results.…”

Antimicrobial activity of RP-1 peptide conjugate with ferrocene group by Natalia C. S. Costa (8626206)

“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC₅₀ = 0.63 μmol L^-1), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”

Characterization of journals being listed on Beall’s list and their development over time (2011–2018). by Georg Richtig (4582933)

Data_Sheet_1_Agronomic evaluation of shade tolerance of 16 spring Camelina sativa (L.) Crantz genotypes under different artificial shade levels using a modified membership function... by Yawen Wang (1578763)

“…The mean chlorophyll pigments, including the total chlorophyll and chlorophyll a and b across the 16 genotypes increased as shade level increased, while the chlorophyll fluorescence parameter F_v/F_m, chlorophyll a/b, leaf area, the number of silicles and branches plant⁻¹ decreased as shade level increased. …”

Image_1_Agronomic evaluation of shade tolerance of 16 spring Camelina sativa (L.) Crantz genotypes under different artificial shade levels using a modified membership function.JPEG by Yawen Wang (1578763)

“…The mean chlorophyll pigments, including the total chlorophyll and chlorophyll a and b across the 16 genotypes increased as shade level increased, while the chlorophyll fluorescence parameter F_v/F_m, chlorophyll a/b, leaf area, the number of silicles and branches plant⁻¹ decreased as shade level increased. …”

Data_Sheet_1_The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity.docx by Zhuo-Qing Li (4455073)

“…Contrarily, the cytotoxicity was decreased in CYP3A4-inhibited PHH and CYP3A4 OE HepG2 and L02 cells inhibited by ketoconazole (KTZ). …”

WT1 mRNA and WT1 lncRNA are co-expressed from the same locus. by Gregory McCarty (708081)

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

The number of amyloid plaques and amount of Aβ_1-42 were reduced in S100A9 KO/Tg mice. by Hee Jin Kim (469168)

“…Sections are 4 µm thick. ((a) – (h) Scale bar; 200 µm, (i)-(l) scale bar; 50 µm). …”

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene <i>OsERF922</i> by Fujun Wang (96184)

“…Here, we report the improvement of rice blast resistance by engineering a CRISPR/Cas9 SSN (C-ERF922) targeting the <i>OsERF922</i> gene in rice. …”