The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile by Shiv K. Sharma (1945762)

“…To circumvent this problem, a series of cholic acid amides were synthesized and tested against R20291. …”

The growth of co-transformed cells in the peritoneal cavity alters their cellular gene expression to mirror that of PEL biopsies. by Mitchell Hayes (5334887)

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity by Baoli Li (4450708)

“…More than 100 new compounds were synthesized, which target the overwhelming the defects of the CrtN inhibitor <b>1</b>. Analogues <b>23a</b> and <b>23b</b> demonstrated a significant activity against pigmented <i>S. aureus</i> Newman and 13 MRSA strains (IC₅₀ = 0.02–10.5 nM), along with lower hERG inhibition (IC₅₀ > 30 μM, ∼10-fold decrease in comparison with <b>1</b>). …”

Image_4_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. …”

Image_2_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. …”

Image_1_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. …”

Image_3_Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina.tif by Pamela E. Rodriguez (13862276)

“…Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. …”

Ab Initio Prediction of Proton Exchange Barriers for Alkanes at Brønsted Sites of Zeolite H‑MFI by Marcin Rybicki (6077435)

“…A change to the indirect proton exchange mechanism, in which a hydride ion is transferred between the alkane and a <i>tert</i>-butyl carbenium ion can be excluded, because we confirm previous findings that the barrier for dehydrogenation that would create a <i>tert</i>-butyl cation from <i>i</i>-butane is much too high, 188 and 132 kJ/mol for the intrinsic and apparent enthalpy barriers, respectively, at 500 K. …”

Brain regions (ROIs) showing significantly increased ReHo in StD group (decreased ReHo in NC) (two sample <i>t</i>-test, thresholded at <i>p</i><0.005 with an extent threshold 5 co... by Zhenling Ma (290924)

Nrf2 is necessary for optimal PMN migration toward CXCL12 and CXCL2 without regulating receptors expression. by Doumet Georges Helou (7255823)

Semi-log plot of the total number of medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of i... by Marcel Ausloos (748325)

Semi-log plot of the number of Gold medals obtained by countries at Beijing (BJG) and London (LDN) recent Summer Olympic Games, as ranked according to their decreasing “order of im... by Marcel Ausloos (748325)

Fatal autoimmune disorder in mice with T_reg cell–specific disruption of <i>miR-142</i>. by Wei-Le Wang (133402)

Relationship between drug effects on animations task performance and emotion recognition performance. by Bianca A. Schuster (18824561)

Data_Sheet_1_The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool.docx by Jocelyn R. Hauser (8493432)

“…The stx_2a+ isolate was avirulent. Both an stx_2a and a recA deletion mutant of one of the stx_2a+stx_2c+ strains, JH2010, exhibited at least a three-log decrease in cytotoxicity in vitro and both were avirulent in the mice. …”

<i>Yap (5SA)</i> mRNA-injected embryos exhibit dramatic downregulation of retinal photoreceptor genes. by Yoichi Asaoka (564124)

“…<p>(A) The top five GO categories for genes downregulated by over 4.0-fold in <i>yap (5SA)</i>-expressing embryos at 48 hpf as determined by microarray analysis. …”

S2 Table - by Penny A. Rudd (10298691)

Data_Sheet_5_Adipokines and Inflammation Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts and Endothelial Cells.PDF by Rebecca Hasseli (6819464)

“…In ECs, tumor necrosis factor α (TNF-α) increased expression of intercellular adhesion molecule 1 (20-fold) and vascular cell adhesion molecule 1 (77-fold), whereas P-selectin was downregulated after stimulation with TNF-α (−6-fold).…”

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Image_5_Integrated plasma metabolomic and cytokine analysis reveals a distinct immunometabolic signature in atopic dermatitis.jpeg by Emily Z. Ma (18157630)

“…</p>Results<p>In patients with AD, amino acids isoleucine, tyrosine, threonine, tryptophan, valine, methionine, and phenylalanine, the amino acid derivatives creatinine, indole-3-acrylic acid, acetyl-L-carnitine, L-carnitine, 2-hydroxycinnamic acid, N-acetylaspartic acid, and the fatty amide oleamide had greater than 2-fold decrease (all P-values<0.0001) compared to healthy controls. …”