Impact on functionality of the paliperidone palmitate three-month formulation in patients with a recent diagnosis of schizophrenia: a real-world observational prospective study by Maria Paz Garcia-Portilla (8898926)

“…The total PSP score increased from a mean of 68.5 (15.3) at baseline to a mean of 72.1 (15.4) at month 6 and 74.8 (16.7) at month 12 with a before-and-after difference of 3.6 (95% CI, 1.6 to 5.5, p < 0.001) at month 6 and 6.2 (95% CI, 4.2 to 8.3, p < 0.001) at month 12. …”

Effect of PPi on ΔΨm during anoxia+tachypacing in rabbit adult ventricular myocytes. by Junko Shibayama (387144)

“…The measurements were normalized to the baseline value recorded at immediately before the initiation of tachypacing (at the time point “−5 min”). ΔΨm-dependent TMRM signal was significantly different between control and PPi groups at all time points between 2 and 20 of tachypacing+anoxia (p<0.05).…”

Distinguishing orthosteric and allosteric effects in Hsp90. by Arun Chandramohan (2813848)

“…<p><b>(A)</b> The absolute difference in numbers of deuterons (y-axis) between the free and ligand bound state is plotted for each pepsin digest fragment listed from the N to C terminus (x-axis) of Hsp90 for each deuterium exchange time point (t = 0.5, 2, 5, 10 min) in a ‘difference plot’. …”

Datasheet1_Totally percutaneous endovascular repair for ruptured abdominal aortic aneurysms.pdf by Shirli Tay (13991808)

“…</p>Results<p>35 patients were identified (21 rPEVAR; 14 rEVAR), 86% were male with a mean age of 72 ± 9 years. All patients underwent emergent endovascular aortic repair with 100% technical success. …”

<b>The association between glycemia, glycemic variability and pregnancy complications in early GDM</b> by Jincy Immanuel (17735170)

“…Women treated early (n=213) showed lower mean glucose (MG) and mean fasting glucose (MFG) compared with those treated late (n=116) (MG:5.7±0.4 vs. 5.9±0.5, p<0.001, MFG:5.2±0.3 vs. 5.3±0.4, p=0.004) with greater optimal glycemia (74.6% vs. 59.5%, p=0.006) and similar glycemic variability. …”

Image_2_Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors.JPEG by Bradley S. Hollidge (14113539)

“…GFP protein expression with the CAG promoter was highest at 3 weeks, and then decreased to stable levels at 3 and 6 months. Surprisingly, GFP mRNA levels continued to increase from 3 weeks to 3 months, despite GFP protein expression decreasing during this time. …”

Image_4_Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors.JPEG by Bradley S. Hollidge (14113539)

“…GFP protein expression with the CAG promoter was highest at 3 weeks, and then decreased to stable levels at 3 and 6 months. Surprisingly, GFP mRNA levels continued to increase from 3 weeks to 3 months, despite GFP protein expression decreasing during this time. …”

Table_1_Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors.pdf by Bradley S. Hollidge (14113539)

“…GFP protein expression with the CAG promoter was highest at 3 weeks, and then decreased to stable levels at 3 and 6 months. Surprisingly, GFP mRNA levels continued to increase from 3 weeks to 3 months, despite GFP protein expression decreasing during this time. …”

Image_3_Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors.JPEG by Bradley S. Hollidge (14113539)

“…GFP protein expression with the CAG promoter was highest at 3 weeks, and then decreased to stable levels at 3 and 6 months. Surprisingly, GFP mRNA levels continued to increase from 3 weeks to 3 months, despite GFP protein expression decreasing during this time. …”

Image_1_Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors.JPEG by Bradley S. Hollidge (14113539)

“…GFP protein expression with the CAG promoter was highest at 3 weeks, and then decreased to stable levels at 3 and 6 months. Surprisingly, GFP mRNA levels continued to increase from 3 weeks to 3 months, despite GFP protein expression decreasing during this time. …”

The IgE repertoire is closely related to the IgG1 repertoire. by Adriana Turqueti-Neves (820798)

“…(D) Morisita-Horn indices show the relatedness (0 = unrelated; 1 = identical) between 1,000 randomly selected CDR3 sequences of the IgE and IgG1 repertoires or IgE and IgM repertoires (mean + standard deviation [SD], <i>n</i> = 3). (E) Mean frequency + SD of silent (blue) and nonsilent (red) mutations in V_H segments of IgG1 and IgE. …”

DataSheet1_The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells.ZIP by Hai-Ling Gao (9501677)

“…However, MK-2206 (0.3 and 1 μM) significantly increased the anticancer efficacy of mitoxantrone, SN-38 and topotecan, in H460/MX20 and S1-M1-80 cancer cells, as indicated by a significant decrease in their IC50 values, compared to cells incubated with vehicle. …”

Table 1_The relationship between dietary sodium intake and all-cause mortality in patients with non-alcoholic fatty liver disease: a cohort study from NHANES 2003–2018.docx by Jiajun Li (1410187)

“…</p>Conclusion<p>This study suggests that higher sodium intake in individuals with NAFLD is associated with increased disease incidence but decreased all-cause mortality. The dose–response relationship between sodium intake and mortality risk exhibited a nonlinear pattern, with a critical inflection point around 3.5 grams per day.…”

Preoperative tranilast as adjunctive therapy to primary pterygium surgery with a 1-year follow-up by Gildásio C. Almeida Junior (5763548)

“…Subjective symptoms were evaluated using a 5-point scale, and the recurrence rate was assessed. …”

Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design - Fig 3 by Arun Chandramohan (2813848)

“…<p><b>(A)</b> The absolute difference in numbers of deuterons (inferred from difference in mass in Daltons (Da) (y-axis) between the free and ligand bound state is plotted for each pepsin digest fragment listed from the N to C terminus (x-axis) of Hsp90 for each Deuterium exchange time point (t = 0.5, 2, 5, 10 min) in a ‘difference plot’. …”

Measuring intracellular viscosity. by Kelly Aubertin (502991)

“…Controls and cells treated with photosensitizers but not exposed all display the same viscosity mean value, in order 0.25 Pa.s. After nocodazole treatment, the mean viscosity value slightly decreases to 0.2 Pa.s but not significantly, while after exposure of the photosensitizers, it increases to 0.4 Pa.s at maximum. …”

Increased colonic injury in DSS treated<i>Mttp-IKO</i> mice. by Yan Xie (41714)

“…<b>E</b>. Colon length at 0, 5 and 7 days on 2.5% DSS. Data are mean ± SE of 4–9 mice per group.…”

Image_3_The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress.jpeg by Trevor J. Buhr (10191398)

“…To that end, young adult male rats were exposed to a single episode of 0, 50, or 100 uncontrollable tail shocks and then given free access to running wheels for 9 weeks. …”

Image_4_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

C6-ceramide nanoliposomes target GAPDH in CLL. by Lindsay K. Ryland (499850)

“…Densitometry analysis from replicate experiments (n=4) was performed via ImageJ software. In Figure A(ii) the representative blot demonstrates a decrease in GAPDH at 12.5µM C6-ceramide, a result not observed in the other two distinct replicate experiments. * <i>P</i> < 0.05; ** <i>P <0 .005</i>. …”