Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression by Leah E. Worton (457030)

Valve hemodynamics during postnatal life in the aortic and pulmonary valve. by Daphne van Geemen (272692)

HuNoV infection slows down intestinal transit. by Arno Cuvry (7405604)

“…<p><b>A)</b> Decrease of fluorescent signal over 4 hours in 5-dpf zebrafish larvae. …”

Quantitative prediction of beneficial heteroplasmy variance generated by different cellular mechanisms. by David M. Edwards (10692265)

Synthetic Spike-in Standards Improve Run-Specific Systematic Error Analysis for DNA and RNA Sequencing by Justin M. Zook (146772)

“…Compared to conventional GATK recalibration that uses reads mapped to the genome, spike-ins improve the accuracy of Illumina base quality scores by a mean of 5 Phred-scaled quality score units, and by as much as 13 units at CpG sites. …”

Exemplar display during target selection. by Joshua B. Moskowitz (8506380)

Data_Sheet_1_Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts.docx by Benjamin A. T. Rodriguez (9107027)

“…Interestingly, sex-stratified analyses indicated the association of MPV with diabetes is markedly stronger in males (β = 0.1232; P = 1.00 × 10⁻³¹) than females (β = 0.0514; P = 7.37 × 10⁻⁵). Among diabetes medications increased MPV was associated with Insulin (β = 0.1341; P = 1.38 × 10⁻¹¹) and decreased MPV with both Metformin (β = 0.0763; P = 1.99 × 10⁻⁶) as well as the sulphonylureas (β = 0.0559; P = 0.0034). …”

Effects of AP-5 application on EPSCs in control and hyperglycemic mice. by Eva C. Bach (709723)

“…<b>D.</b> Mean percent decrease in mEPSC frequency following application of AP-5 in control (n = 9) and hyperglycemic (n = 10) mice. …”

Linear mixed model results: Effect of bar height and approach stride number on kinetics at take-off to a jump in agility dogs. by Leena Inkilä (20614460)

Performance of the model with the inhibitory V0_D pathways removed. by Yaroslav I. Molkov (542831)

“…Decreasing <i>α</i> causes two bifurcations: (i) transition from symmetric alternations of flexor activity, i.e. with a phase difference of Δ<i>φ</i> = 0.5, to alternations with a phase difference of Δ<i>φ</i> ≠0.5 at X₇ and then (ii) from alternation to synchronization of flexor activity at X₆. …”

Quality of life and Beck Depression Inventory baseline and post CRT+MRT, CRT and RUHB. by Sergio R. Thomaz (20308465)

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Cardiorespiratory variable measurement of the study population. by Sergio R. Thomaz (20308465)

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ΔQuality of life and ΔBeck Depression Inventory baseline and post CRT+MRT, CRT and RUHB. by Sergio R. Thomaz (20308465)

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Changes in maximal strength within each group after treatment. by Sergio R. Thomaz (20308465)

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ΔVO₂ (ml/min), ΔVO₂/HR and ΔVE/VCO₂ slope baseline and post CRT+MRT, CRT and RUHB. by Sergio R. Thomaz (20308465)

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Role of the ACB domain and linker region in NMT2 activity. by Eric Soupene (64584)

“…Human NMT2 enzyme was added at a concentration of 50nM in the presence of 5μM C₁₄-CoA. …”

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo by Zhiqiang Li (102723)

“…The overexpression of NIK plays a critical role in liver inflammatory diseases. …”

Pre-diabetes is associated with increased risk of heart failure among patients with atrial fibrillation by Jia-Yi Huang (12733928)

“…</p> <p><strong>Results</strong>: Among 17,943 AF patients (mean age 75.5 years, 47% female), 3,711 (20.7%) had pre-diabetes and 10,127 (56.4%) had diabetes at baseline. …”

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Knockdown of IFI27 impairs LCL survival <i>in vitro</i> and <i>in vivo</i>. by Ken Sagou (1945318)