Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with <i>In Vivo</i> Efficacy in Multip... by Obdulia Rabal (124515)

“…The corresponding epigenetic functional cellular responses are observed: histone-3 acetylation, DNA hypomethylation, and decreased histone-3 methylation at lysine-9. These chemical probes, multitarget epigenetic inhibitors, were validated against the multiple myeloma cell line MM1.S, demonstrating promising <i>in vitro</i> activity of <b>12a</b> (CM-444) with GI₅₀ of 32 nM, an adequate therapeutic window (>1 log unit), and a suitable pharmacokinetic profile. …”

Task structure. by Ana Todorovic (709034)

Expression of CRYAB in normal and tumor tissue samples across different cancer types. by Rasool Saghaleyni (10526301)

DNMT1 reduces cisplatin sensitivity partially through downregulating FOXO3a in ovarian cancer cells by Chong Guo (5819105)

“…Knocking down of DNMT1 could decrease the IC₅₀ of cisplatin. Treatment with cisplatin may reduce FOXO3a expression in OC cells. …”

miR-223 Is a Coordinator of Breast Cancer Progression as Revealed by Bioinformatics Predictions by Eva Maria Pinatel (506111)

Image_1_Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.TIF by In-Young Choi (3025167)

Image_2_Interleukin-17A Mediates Hippocampal Damage and Aberrant Neurogenesis Contributing to Epilepsy-Associated Anxiety.TIF by In-Young Choi (3025167)

A randomized controlled trial of a combination of antiviral and nonsteroidal anti-inflammatory treatment in a bovine model of respiratory syncytial virus infection by Paul Walsh (662015)

“…This benefit was greater when treatment was initiated at 3 days rather than 5 days post infection with decreased clinical scores and lower respiratory rates at both time points. …”

Model fit for the single-fire models. by Erin Conlisk (163376)

Density plots (A) and restricted cubic splines (B) of the associations of 1-year change (%) in weight and waist circumference after diabetes diagnosis with incident remission of ty... by Hongjiang Wu (449543)

Characterization of UKF-NB-MV. by Hila Naaman (4538170)

YorkU.forest.Oct25-2016.csv by Andrew Laruffa (3116073)

“…</p><p>The methods are as follows:</p><p>-A transect measuring 50m was randomly placed.</p><p>-For every two meters along the transect:</p><p>·      The number of woody plants was counted on either side of the transect that were within 0.5 meters.…”

Suppression by extracellular QRNA from TNP Ts Sup free of exosomes, or miR-150 alone, associating with B-cell derived Ag-specific exosomes from the assayed CS-effector cell mixture... by Krzysztof Bryniarski (731989)

“…</b></u> Similarly, two day immune B-1 B cell-derived exosomes, supplemented with decreasing doses of miR-150 alone, mediated suppression of TNP-CS-effector cell adoptive transfer (Groups E-G), down to a dose of 750pg per eventual recipient, which is 50 femtomoles per eventual recipient (Group G). …”

Predicting clonality detection. by Even H. Rustad (6499169)

Localization of auditory activation. by Ana Todorovic (709034)

The inverse illuminance‒speeding relationship. by Emanuel de Bellis (4732503)

Egg mass output for uninfected snails in treatment groups 0.38 ppt, 1.9 ppt, 3.8 ppt, and 5.7 ppt. by Ao Yu (1348512)

Portfolios with different number of securities involved in E(r) – risk system. by Mihály Ormos (697939)

Map of study area. by Erin Conlisk (163376)

Variable-precision model of VWM. by Yi-Jie Zhao (11663148)