An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos by Sergio Jarque (5698859)

“…<div><p>The knowledge on environmentally relevant chemicals that may interfere with thyroid signaling is scarce. Here, we present a method for the screening of goitrogens, compounds that disrupt the thyroid gland function, based on the automatic orientation of zebrafish in a glass capillary and a subsequent imaging of reporter gene fluorescence in the thyroid gland of embryos of the transgenic zebrafish line tg(tg:mCherry). …”

Electrical impedance cole parameters. by W. David Arnold (3373874)

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1 by María Dolores Moya-Garzón (5597540)

“…We introduce here an unprecedented activity of salicylic acid derivatives as agents capable of decreasing oxalate output in hyperoxaluric hepatocytes at the low micromolar range, which means a potential use in the treatment of PH1. …”

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1 by María Dolores Moya-Garzón (5597540)

“…We introduce here an unprecedented activity of salicylic acid derivatives as agents capable of decreasing oxalate output in hyperoxaluric hepatocytes at the low micromolar range, which means a potential use in the treatment of PH1. …”

Expression levels of IL-5Rα, CCR3 and MBP correlated with the expression of miRNAs that potentially target these transcripts. by Ming Yang (109148)

“…<p>Bone marrow cells were cultured as described in Methods and RNA samples were extracted from day 4 to day14 from cells grown in the presence of IL-5. <i>A</i>. Expression levels of IL-5Rα, CCR3 and MBP were determined by qPCR. …”

Potency and breadth of subject immune sera. by Chad D. Nix (8704143)

“…The plot for each serum shows the proportion of viruses neutralized by FRNT₅₀ at a given serum dilution. Each step in each plot represents an FRNT₅₀ value for one virus; as fold serum dilution increases for each serum, the proportion of viruses neutralized decreases by 1/11 (9.1%) as each FRNT₅₀ dilution for each virus is crossed. …”

Image_5_Elucidating the changes in the heterogeneity and function of radiation-induced cardiac macrophages using single-cell RNA sequencing.tif by Chunxiang Cao (451327)

“…</p>Results<p>Cardiac function temporarily decreased on Day 7 and returned to normal level on Day 35, accompanied by macrophages decreased and increased respectively. …”

Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C^∧N‑Chelated and Pyridine Ligands by Zhe Liu (77240)

“…The monodentate py ligands blocked hydrolysis; however, antiproliferative studies showed that all the Ir compounds are highly active toward A2780, A549, and MCF-7 human cancer cells. In general the introduction of an electron-donating group (e.g., Me, NMe₂) at specific positions on the pyridine ring resulted in increased antiproliferative activity, whereas electron-withdrawing groups (e.g., COMe, COOMe, CONEt₂) decreased anticancer activity. …”

Table_3_Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats.XLSX by Tiantian Zhu (8254053)

“…Rats with BCCAO developed VD. Pur (50, 100, and 150 mg/kg) dose-dependently attenuated the pathological changes, increased synaptic structural plasticity in the dorsal CA1 hippocampal region and decreased oxidative stress, which eventually reduced cognitive impairment and vascular injury in BCCAO rats. …”

Image_1_Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats.TIF by Tiantian Zhu (8254053)

“…Rats with BCCAO developed VD. Pur (50, 100, and 150 mg/kg) dose-dependently attenuated the pathological changes, increased synaptic structural plasticity in the dorsal CA1 hippocampal region and decreased oxidative stress, which eventually reduced cognitive impairment and vascular injury in BCCAO rats. …”

Table_1_Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats.docx by Tiantian Zhu (8254053)

“…Rats with BCCAO developed VD. Pur (50, 100, and 150 mg/kg) dose-dependently attenuated the pathological changes, increased synaptic structural plasticity in the dorsal CA1 hippocampal region and decreased oxidative stress, which eventually reduced cognitive impairment and vascular injury in BCCAO rats. …”

Table_2_Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats.xlsx by Tiantian Zhu (8254053)

“…Rats with BCCAO developed VD. Pur (50, 100, and 150 mg/kg) dose-dependently attenuated the pathological changes, increased synaptic structural plasticity in the dorsal CA1 hippocampal region and decreased oxidative stress, which eventually reduced cognitive impairment and vascular injury in BCCAO rats. …”

Recruitment of α5-GABA_ARs to PV-synapses contributes to wake-dependent enhancement of iLTP. by Kunwei Wu (725668)

“…(K) Representative PV-IPSC traces at indicated time points in (J). (L) L655,708 decreased the potentiation of PV-IPSC amplitude after NMDA application in wake and sleep-deprived mice (SD) but not sleep mice (<i>n</i> = 7–8, 2-way ANOVA, F (4, 38) = 4.234, <i>p</i> = 0.0062 with Sidak’s multiple comparison test, Sleep a versus Sleep b, <i>p</i> = 0.028; Sleep a versus Sleep c, <i>p</i> = 0.04; Wake a versus Wake b, <i>p</i> = 0.0014; Wake b versus Wake c, <i>p</i> = 0.023; Wake a versus Wake c, <i>p</i> = 0.0008; SD a versus SD b, <i>p</i> < 0.0001; SD b versus SD c, <i>p</i> = 0.0091; SD a versus SD c, <i>p</i> = 0.0002; Sleep b versus Wake b, <i>p</i> = 0.028; Sleep b versus SD b, <i>p</i> = 0.04). …”

DataSheet_1_Population-based study of the durability of humoral immunity after SARS-CoV-2 infection.pdf by David Peterhoff (5069261)

“…We investigated levels and temporal change of SARS-CoV-2 antibody quantity and quality. We analyzed sera (8 binding, 4 avidity assays for spike-(S-)protein and nucleocapsid-(N-)protein; neutralization) from 211 seropositive unvaccinated participants, from the population-based longitudinal TiKoCo study, at three time points within one year after infection with the ancestral SARS-CoV-2 virus. …”

Table_5_Exercise Reverses the Alterations in Gut Microbiota Upon Cold Exposure and Promotes Cold-Induced Weight Loss.XLSX by Yan Meng (28903)

Transgenerational hormetic effects of sublethal dose of flupyradifurone on the green peach aphid, <i>Myzus persicae</i> (Sulzer) (Hemiptera: Aphididae) by Qiuling Tang (495407)

“…<i>persicae</i> with a 48 h LC₅₀ of 8.491 mg/L. Using the age-stage two-sex life table approach, we assessed the effects of LC₂₅ of flupyradifurone on adult <i>M</i>. …”

5‑Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer’s Disease Phenotypes by Hsueh-Yun Lee (141907)

“…<i>N</i>-Hydroxy-4-((5-(4-methoxybenzoyl)-1<i>H</i>-indol-1-yl)­methyl)­benzamide (<b>6</b>) has potent inhibitory selectivity against histone deacetylase 6 (HDAC6) with an IC₅₀ value of 3.92 nM. It decreases not only the level of phosphorylation of tau proteins but also the aggregation of tau proteins. …”

Data_Sheet_1_Serious games and eating behaviors: A systematic review of the last 5 years (2018–2022).PDF by Pierpaolo Limone (10821258)

Effects of Sediment Characteristics on the Toxicity of Chromium(III) and Chromium(VI) to the Amphipod, <i>Hyalella azteca</i> by John M. Besser (467734)

“…Waterborne Cr(VI) caused reduced survival of amphipods with a median lethal concentration (LC₅₀) of 40 μg/L. …”

Catalytic residues are more conserved than residues in protein–protein interfaces, and interface residues induce much weaker evolutionary rate gradients relative to catalytic resid... by Benjamin R. Jack (2637040)