Effect of fenretinide and its metabolites on SCD expression and activity. by Eugenia Poliakov (116500)

“…<p>A) SCD1 protein expression is decreased after treatment with fenretinide, and its metabolite 3-keto-HPR. …”

TNFAIP9 expression was increased in mice with chronic kidney disease (CKD) induced by 5/6 nephrectomy (Nx). by Ying Chen (9697)

Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers by Viera Dobrotkova (6832433)

“…We found that the cell lines that were HMGA2-positive and/or HOXC9-negative have a reduced sensitivity to retinoids. Furthermore, the experiments revealed that the retinoid-sensitive cell lines showed a uniform pattern of change after treatment with both natural and sensitive retinoids: increased DDX39A and decreased PBX1 protein levels. …”

Modulation of Aβ-induced deleterious signaling. by Tao Yang (184280)

“…(H) In DIV 21–22 hippocampal neuronal cultures examined at the 3 hour time point, Aβ significantly decreased CREB phosphorylation by 43%, while this decrease was prevented by LM11A-24 and -31 (n = 10 separate Western blots from 5 independent protein preparations).…”

Supplementary Material for: Development of a root caries prediction model in a population of dental attenders by Fee P.A. (13545517)

Noise pollution limits metal bioaccumulation and growth rate in a filter feeder, the Pacific oyster <i>Magallana gigas</i> by Mohcine Charifi (4535101)

“…This latter conclusion points towards a potential risk in terms of ecosystem productivity.…”

Down-regulation of BjsR4 under tellurite and iron stresses, and impact of this down-regulation on survival at high iron concentration. by Julia Hahn (3279486)

“…<p><b>A)</b> The steady-state level of BjsR4 is decreased upon addition of tellurite. …”

Deletion of <i>NUO2</i> triggers a ROS-dependent signaling pathway involving Hog1 activation and Brg1 repression in conditions when mannitol is the sole carbon source. by Xinhua Huang (1905940)

Temperature-dependence of A) the ratio of rate constants k1/k2. The presence of the DII loop made the first rate constant ratio less affected by temperature changes, as seen for <i... by Roberto F. Delgadillo (843498)

CI-regulated utilization of alternative carbon sources is vital for <i>C</i>. <i>albicans</i> commensalism in GI tract. by Xinhua Huang (1905940)

Overexpression of TNFAIP9 counteracted the renal damage caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity by Brandon L. Probst (727964)

“…Here, we characterized the in vitro antioxidant, anti-inflammatory, and anticancer activities of RTA 408, a novel AIM that is currently being evaluated in patients with advanced malignancies. …”

An Analysis of Porphyrin Molecular FlexibilityUse of Porphyrin Diacids by Beisong Cheng (2970567)

“…Molecular mechanics calculations, using a modified version of MM2(87) and a newly developed force field for porphyrin diacids, correctly predict that the flexibility of <i>meso</i>-tetraaryl porphyrin diacids decreases as the steric bulk of the peripheral substituents increases:  [H₄TPyP]²⁺ ≈ [H₄TPP]²⁺ > [H₄T-2,6-(OH)₂ PP]²⁺ ≈ [H₄T-2,6-F₂ PP]²⁺ > [H₄T-2,6-Cl₂ PP]²⁺ ≈ [H₄TMP]²⁺. …”

Mean best-corrected visual acuity (BCVA) ± standard error of the means (± SEM) before and at 1, 2, 3, 4, 5 years and final visit following the LMT surgery. by Hisaaki Oshima (4042748)

“…<p>The BCVA was significantly improved at 1 year after surgery (<i>P</i> = 0.015), and the improved BCVA was maintained for at least 5 years after the surgery. In comparison with the preoperative BCVA, the BCVAs at all of the 3 postoperative time points (Year 1, Year 5, and the final examination) are improved by 2 or more lines of the visual acuity chart in 9 of the 20 eyes (45%), no change in 8 (40%), and decreased in 3 eyes (15%).…”

P2X7 knock-out abolishes cell migration. by José David Nuñez-Ríos (18823719)

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schönlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registr... by Hiroyuki Komatsu (2292505)

“…The primary end-points comprised a 50% increase in serum creatinine (sCr) values or end-stage kidney disease. …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Cell morphology varies among genetically distinct subgroups. by Laura K. Jackson (9922803)

“…<b>(D)</b> Subgroup 2B labeled with amino acid mutations in cell shape determining proteins (Csd4, Csd5, Csd6).</p>…”