Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies by Brianna D. Mackie (9212677)

“…Its cell-permeable analogue <b>DC432</b> (IC₅₀ of 54 ± 4 nM) decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins in HCT116 cells. …”

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes by Wipawee Wongchana (5367968)

“…A similar impact on IL-10 production was observed when Notch signaling was inhibited with a gamma-secretase inhibitor (GSI). …”

Effects of GSI treatment on MAPK, PI3K/AKT and NF-κB pathway activation in LPS/IC-activated macrophages. by Wipawee Wongchana (5367968)

“…The arrows indicate cells with decreased or no p50 nuclear translocation (green). …”

Liquid cultures in RPMI-1640. by Nicholas C. Schena (16541975)

Data_Sheet_1_Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score.docx by Mohammad Abumayyaleh (9704657)

“…</p><p>Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO₂) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). …”

Image_1_v1_Case Report: J-Shaped External Fixator for Treatment of Mayo Type II Olecranon Fractures – A Novel Surgical Technique and Report of Clinical Applications.tif by Yue Tian (1765825)

“…The mean DASH score was 14.1 points, and the mean MEPS was 93.9 points. Operative time and intraoperative blood loss were decreased by 41.3% and 64.6%, respectively, in J-EF patients than those in a comparable group treated by TBW. …”

Evaluation of Efficiency of Liposome-Entrapped Iridium(III) Complexes Inhibiting Tumor Growth In Vitro and In Vivo by Huiyan Hu (9376570)

“…Surprisingly, its liposome-entrapped complexes 3alip, 3blip, and 3clip on B16 cells showed strong cytotoxicity (IC₅₀ = 13.6 ± 2.8, 9.6 ± 1.1, and 18.9 ± 2.1 μM). …”

Estimated numbers of people aged 65+ years living with dementia under various scenarios and difference to ageing-only scenario. by Binod Nepal (625271)

Fig 1 - by Gilda Cennamo (448296)

“…</b> Left eye of a patient (50 years-old female) with pitituary adenoma before surgery reveals a reduction of vessel density in SCP (A1), DCP (B1), RPC (C1) and an increase of FAZ area (D1) respect to healthy subject. …”

DRP2B is partially required for flg22-induced endocytosis of FLS2. by John M. Smith (676719)

“…Representative maximum-intensity projection images and zoomed insets of FLS2-GFP fluorescence are shown, with bright pixels corresponding to increased abundance of FLS2-GFP at a given location. Scale bars = 10 µm. (D) Quantification of FLS2-GFP in puncta at 0, 35–45 or 50–60 min after elicitation with 1 µM flg22 indicates that loss of <i>DRP2B</i> resulted in ∼20% decrease in flg22-stimulated endocytosis of FLS2-GFP (35–45 min, P = 0.0204; 50–60 min, P = 0.0396). …”

Differential expression of actin regulators and <i>Lphn3</i> related genes in the striatum of High-Active and Control mice. by Anastasia M. Sorokina (5635070)

Electronic configuration of the polypeptide backbone versus complexity of tertiary structure and order of oligomerization in soluble and integral membrane proteins. by Andrzej Stanisław Cieplak (2717653)

“…Δ<i>FP</i>_{<i>i-1→i+1</i>} plots for the antiparallel β sheets that assemble ‘C₅ strands’ or ‘C_7eq strands’ and ‘<i>FP</i>_<i>i</i>>>0 turns’, panels <b>(C)</b> and <b>(D)</b>, even though large differences in the folding potential values and wide distribution of the slope values, from Δ<i>FP</i>_{<i>i-1→i+1</i>} ~ ‒1 to Δ<i>FP</i>_{<i>i-1→i+1</i>} ~ 1, generate in this case circular distribution of data points. …”

Image_5_Induction of Protective Immunity by a Single Low Dose of a Master Cell Bank cGMP-rBCG-P Vaccine Against the Human Metapneumovirus in Mice.tiff by Jorge A. Soto (6059606)

Participation of NO pathway in CNP induced relaxation. by Carolina Caniffi (444744)

Examples of dynamic response of g_s and A_max after detachment of the leaf (A: calculation of the dynamic parameters in a leaf with 0% visible injury, B: time c... by Yasutomo Hoshika (319347)

Table_5_Brain Oscillatory and Hemodynamic Activity in a Bimanual Coordination Task Following Transcranial Alternating Current Stimulation (tACS): A Combined EEG-fNIRS Study.DOCX by Alisa Berger (5113163)

Cashtags become substantially more popular after Musk purchased X. by Daniel Hickey (20714822)

Segmentation and Visual Analysis of Whole-Body Mouse Skeleton microSPECT by Artem Khmelinskii (121543)

“…The obtained results indicate that after registration, the mean Euclidean distance decreased from 11.5±12.1 to 2.6±2.1 voxels. The proposed approach yielded satisfactory segmentation results with minimal user intervention. …”

Minimal dataset. by Herindita Puspitaningtyas (11618232)

“…During 2008–2019, trends of colon cancer in age <50 increased by 8.15% annually while rectal cancer displayed a 9.71% increase annually prior to 2017, followed by a 17.23% decrease until 2019.…”

i(A)CG strategies in the final population. by Anton M. Unakafov (5706560)