Supplementary Material for: Should Colorectal Cancer Screening in Portugal Start at the Age of 45 Years? A Cost-Utility Analysis by Currais P. (10117210)

“…<b><i>Results:</i></b> In Portugal, in 1993–2010, there was an increase in CRC incidence of 17% (from 25 to 30/100,000), 35% (from 39 to 54/100,000), and 71% (from 52 to 97/100,000) in patients aged 45–49 years, 50–54 years, and 55–59 years, respectively. The mortality rate of patients aged 45–54 years remained stable between 2003 and 2016 (12/100,000) as a counterpoint to a moderate decrease in those aged 55–64 years (from 38 to 35/100,000) and a sharp reduction in those aged 65–75 years (from 93 to 75/100,000). …”

N-AChR has phylogenetic declining response and delayed expression in oocytes. by Jennifer D. Noonan (14117157)

“…The declining response indicates a progressive adaptation has occurred within the clade that decreases response to ligand. …”

Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial by Lilian Vliek (8053037)

“…Within-participant t-tests in the intervention group between post-intervention and follow-up indicated that effects extended over a six-month follow-up period. Depression decreased significantly from post-test to follow-up. …”

Gene Mutation in MicroRNA Target Sites of CFTR Gene: A Novel Pathogenetic Mechanism in Cystic Fibrosis? by Felice Amato (394509)

“…The expression analysis demonstrated that the c.*1043A>C increases the affinity for miR-509-3p and slightly decreases that for the miR-433. …”

Table_1_Comparison of Carrier and de novo Pathogenic Variants in a Chinese DMD/BMD Cohort.DOCX by Jinfu Lin (5632655)

“…With advances in prenatal diagnosis decreasing the number of affected offspring from carrier mothers, the frequency of de novo variants could increase. …”

Senescent LNCaP cells display a pro-survival phenotype and upregulate IL-8 mRNA. by Dominick G. A. Burton (428523)

“…<p>(<b>A</b>) Western blot of survival markers in LNCaP cells growing in FBS and CSS day 5, 10 and 17. …”

Image_1_Comparison of Carrier and de novo Pathogenic Variants in a Chinese DMD/BMD Cohort.TIF by Jinfu Lin (5632655)

“…With advances in prenatal diagnosis decreasing the number of affected offspring from carrier mothers, the frequency of de novo variants could increase. …”

Image_2_Comparison of Carrier and de novo Pathogenic Variants in a Chinese DMD/BMD Cohort.TIF by Jinfu Lin (5632655)

“…With advances in prenatal diagnosis decreasing the number of affected offspring from carrier mothers, the frequency of de novo variants could increase. …”

Genetic Impact of a Severe El Niño Event on Galápagos Marine Iguanas (<em>Amblyrhynchus cristatus</em>) by Sebastian Steinfartz (80489)

“…Based on microsatellite data, only one island (Marchena) showed signatures of a genetic bottleneck, where the harmonic mean of the effective population size (<em>N_e</em>) was estimated to be less than 50 individuals during the period between samplings. …”

Data_Sheet_1_Sex-Specific Associations of Diabetes With Brain Structure and Function in a Geriatric Population.PDF by Elias G. Thomas (12965714)

“…Introduction<p>Globally, women with dementia have a higher disease burden than men with dementia. …”

The role of IRF-1 in mediating T-cell immune imbalance in systemic lupus erythematosus and the construction of a diagnostic model by Zichen Huang (6587885)

“…The IRF-1–associated gene–based machine learning model provides a robust, noninvasive diagnostic tool.</p>…”

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system by M.C.O. Citó (6516527)

“…The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice exposed to a forced swimming test (FST). …”

Table 1_Effects of different reduction patterns on stress distribution in patients with intertrochanteric fractures with intramedullary nail fixation: a finite element analysis.xls... by Jiajing Zhu (5117738)

“…</p>Results<p>As the head–neck fragment moved forward, the von Mises stress at the fracture surface, the proximal intersection point of the intramedullary nail, and the distal intersection point gradually decreased. …”

Productive effects of a colostrum-oriented amino acid dietary supply for sows in transition from gestation to lactation by Diana Luise (4917283)

“…</p><p>The pre-weaning mortality can be decreased by feeding sows a diet with an amino acid profile closer to that of colostrum.…”

Table_1_Gout and risk of dementia, Alzheimer's disease or vascular dementia: a meta-epidemiology study.DOCX by Xuanlin Li (9284439)

“…The pooling analysis shows that the risk of all-cause dementia was decreased in gout patients [RR = 0.67, 95% CI (0.51, 0.89), I² = 99%, P = 0.005, very low quality], especially in gout patients with medication [RR = 0.50, 95% CI (0.31, 0.79), I² = 93%, P = 0.003, low quality]. …”

Post-Exercise Hypotension and Its Mechanisms Differ after Morning and Evening Exercise: A Randomized Crossover Study by Leandro C. de Brito (771988)

“…At each time of day, subjects underwent an exercise (cycling, 45 min, 50%VO₂peak) and a control (sitting rest) session. …”

Table_2_Gout and risk of dementia, Alzheimer's disease or vascular dementia: a meta-epidemiology study.DOC by Xuanlin Li (9284439)

“…The pooling analysis shows that the risk of all-cause dementia was decreased in gout patients [RR = 0.67, 95% CI (0.51, 0.89), I² = 99%, P = 0.005, very low quality], especially in gout patients with medication [RR = 0.50, 95% CI (0.31, 0.79), I² = 93%, P = 0.003, low quality]. …”

Datasheet3_Genetic association of lipids and lipid-lowering drugs with sepsis: a Mendelian randomization and mediation analysis.docx by Chen Lou (16790187)

“…The indirect impact of ApoA-I explained over 50% of the curative effects of CETP inhibitors in sepsis.…”

Datasheet2_Genetic association of lipids and lipid-lowering drugs with sepsis: a Mendelian randomization and mediation analysis.docx by Chen Lou (16790187)

“…The indirect impact of ApoA-I explained over 50% of the curative effects of CETP inhibitors in sepsis.…”

Datasheet1_Genetic association of lipids and lipid-lowering drugs with sepsis: a Mendelian randomization and mediation analysis.xlsx by Chen Lou (16790187)

“…The indirect impact of ApoA-I explained over 50% of the curative effects of CETP inhibitors in sepsis.…”