Identification of Chalcones as <i>Fasciola hepatica</i> Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach by Florencia Ferraro (3146766)

“…One of the compounds, <b>C34</b>, tightly bounds to juvenile specific <i>Fh</i>CL3 with an IC₅₀ of 5.6 μM. We demonstrated that <b>C34</b> is a slow-reversible inhibitor that interacts with the Cys-His catalytic dyad and key S₂ and S₃ pocket residues, determinants of the substrate specificity of this family of cysteine proteases. …”

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature by Kathleen Ridgeway (4479478)

“…Moreover, HIV-related mortality increased by 50% between 2005 and 2012 for adolescents 10–19 years while it decreased by 30% for all other age groups. …”

A simple stochastic step model explains Reactive Oxygen Species production in cell populations undergoing senescence and in immortal cells. by Conor Lawless (183686)

“…B) Normalised, mean MitoSOX fluorescence measured by flow cytometry varies with PD in MRC5 fibroblasts cultivated until senescence (blue points). …”

Capillaries are depicted more clearly with extension (IST_7.6, IST_12.0, and IST₂₀) of the interscan time; OCTA images of the healthy macular area in... by Masaharu Ishikura (4338823)

ZC3H18 regulates NF-kB components independently of LMP1. by Huanzhou Xu (8129922)

ART reduces the number of SPION+ perivascular macrophages and increases the number of SPION+ macrophages trafficking out. by Zoey K. Wallis (17725175)

Representative μCT image slice of the femoral cortical mid-diaphysis (thresholded). by Daksh Arora (16510065)

Data_Sheet_4_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Data_Sheet_1_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Data_Sheet_3_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOCX by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Data_Sheet_2_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Supplementary Material for: Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis by Wang X. (2828795)

“…<b><i>Conclusions:</i></b> This review suggests that metformin can decrease the incidence of perinatal complications, and it should be considered as a generally safe alternative to insulin.…”

S2 Fig - Transcriptome profiling of <i>L. infantum</i>-infected human macrophages reveals sex-specific type I interferon induction by Annika Bea (17686341)

Biocompatible and Antifouling Linear Poly(<i>N</i>‑(2-hydroxypropyl)methacrylamide)-Coated Capillaries via Aqueous RAFT Polymerization Method for Clinical Proteomics Analysis of No... by Mengqing Yang (13253917)

The health care utilization of people in prison and after prison release: A population-based cohort study in Ontario, Canada by Fiona G. Kouyoumdjian (489495)

“…<div><p>Background</p><p>Many people experience imprisonment each year, and this population bears a disproportionate burden of morbidity and mortality. …”

Data Sheet 1_Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.pdf by Tianmin Huang (20561477)

“…HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”

A Novel Role for Wnt/Ca²⁺ Signaling in Actin Cytoskeleton Remodeling and Cell Motility in Prostate Cancer by Qin Wang (109812)

“…Very little is known about the mechanisms of Wnt signaling in prostate cancer, a leading cause of death in men. A quantitative analysis of the expression of Wnt5A protein in human tissue arrays, containing 600 prostate tissue cores, showed >50% increase in malignant compared to benign cores (<em>p</em><0.0001). …”

The rescue intervention strategy for asthma patients under severe air pollution: a single-center prospective randomized controlled trial by Xiaoyu Yang (547580)

“…</p> <p>A novel strategy to administer treatment at the first signs of severe air pollution and before patients experience symptoms may decrease the risk of asthma exacerbations and negative outcomes under severe air pollution conditions.…”

DataSheet1_Prognostic value of oxygen inhalation therapy for simple nocturnal hypoxemia in COPD: a meta-analysis.pdf by Ling Sun (301114)

“…The publication bias and heterogeneity of the included studies were evaluated.</p><p>Results: A total of 621 patients from 5 studies were included in this meta-analysis, and there was no publication bias in the included studies. …”

Data Sheet 3_Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.pdf by Tianmin Huang (20561477)

“…HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”