Flow cytometry analysis of the changes in T cell and B cell proportions in iNOS-KO and WT control rats. by Jia Shen (1828945)

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo by Er-Jun Hao (10097665)

“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC₅₀ = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”

Correlation between total memory or naïve Tregs with PD1⁺ CD95⁺ cells. by Vedran Brezar (337452)

Cell-targeted transgenic control of 5HT_2AR levels in neurons and glia during the experience-dependent critical period. by Vanessa Kay Miller (19775496)

“…Two-way ANOVA with Tukey’s multiple comparison shows EB experience-dependent increase in 5HT_2A receptor levels in both transgenic controls (<i>n</i> = 10 each, <i>repo-</i>Gal4<i>; p</i> = 5.38 × 10⁻¹⁰, <i>elav</i>-Gal4; <i>p</i> = 0.0205), a significant decrease in 5HT_2A receptor levels in both RNAi conditions (<i>n</i> = 10 each, <i>repo-</i>Gal4<i>; p</i> = 4.63 × 10⁻¹⁰, <i>elav-</i>Gal4; <i>p</i> = 1.05 × 10⁻⁹), and a significant elevated EB response with glial <i>5HT</i>_<i>2A</i><i>R</i> OE (<i>n</i> = 10/condition, <i>p</i> = 2.36 × 10⁻⁹). …”

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene <i>OsERF922</i> by Fujun Wang (96184)

“…Here, we report the improvement of rice blast resistance by engineering a CRISPR/Cas9 SSN (C-ERF922) targeting the <i>OsERF922</i> gene in rice. …”

A Randomized Clinical Trial to Evaluate Two Doses of an Intra-Articular Injection of LMWF-5A in Adults with Pain Due to Osteoarthritis of the Knee by David Bar-Or (518741)

Effect of DM, and/or <i>M. charantia</i> on the immuno-expressional level of GFAP protein in maternal cerebellar tissue of different groups. by Amoura M. Abou-El-Naga (21001524)

Skeletal abnormalities in <i>Slc35a3</i>^{<i>–/–</i>}mice. by Soichiro Saito (15285875)

The influence of <i>PINK1</i> on <i>P</i>. <i>berghei</i> infection in <i>A</i>. <i>stephensi</i>. by Li Gao (131516)

Expression of Ki67 antigen and induction of apoptosis in response to resveratrol treatment. by Mehtap Kilic Eren (591048)

HIV-specific CD4⁺ T-cell responses were amplified by IL-2 treatment and inversely correlate with VL after treatment interruption. by Vedran Brezar (337452)

Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease by Yaru Jiang (17458815)

“…Notably, patients with <i>ATP6V0A4</i> mutations were diagnosed at a younger age (mean 0.5 years) and exhibited more severe renal impairment, including reduced estimated glomerular filtration rate (eGFR), indicating heightened susceptibility to kidney damage. …”

Generation of <i>Slc35a3</i>^–/–mice using genome editing. by Soichiro Saito (15285875)

Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice by Sabrina N. Dumas (5474456)

“…<div><p>Stearoyl-CoA desaturase 1 (SCD1) catalyzes the rate limiting step in monounsaturated fatty acid synthesis by inserting a double bond at the delta-9 position of long-chain fatty acids. …”

ssDNA replication profiling of <i>SLD2</i> Anchor Away cells. by Kelsey L. Lynch (7465649)

Viral and hinge length mechanisms of enhanced Fc effector function and neutralization potency of IgG3 bNAbs. by Simone I. Richardson (5076992)

“…<p><b>(A)</b> Fold-difference in IC₅₀ neutralization titres between IgG1 and IgG3*01 versions of CAP256.25 among 36 viruses with/without a potential PNG at position 160. …”

Glycosaminoglycan (GAG) synthesis is impaired in the spine and limbs of <i>Slc35a3</i>^{<i>–/–</i>}mice. by Soichiro Saito (15285875)

Functional annotation of human missense SNVs. by Pete Heinzelman (7509374)

“…The binding signal is defined as mean fluorescence for yeast-displayed ACE2 spike binding divided by mean fluorescence corresponding to ACE2 display level on the yeast surface (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0251585#pone.0251585.s004" target="_blank">S4</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0251585#pone.0251585.s005" target="_blank">S5</a> Figs). …”

Image 2_v1_Arthroscopy-assisted partial trapeziectomy combined with ligament reconstruction for thumb carpometacarpal joint osteoarthritis: A different technique.tif by Wan-Ling Zheng (13772251)

“…</p>Results<p>Ten patients were monitored at a mean follow-up of 6.8 years. The mean grip strength improved significantly from 16.64 to 22.57 kg after surgery. …”