BMAL1 and PER1 protein and transcript levels are reduced by thyroxine treatment. by Jonathan A. Hardman (714625)

“…(b,d) PER1 protein was significantly decreased by T4 at 6, 12,18 and 24 hours. BMAL1 protein levels were also decreased significantly by T4 at time points 6,12 and 18 hours showing a tendency to decrease at 0 and 24 hours. …”

AXL overexpression dampens the response to IFNα. by Scott A. Read (788751)

“…<p>Stable transfection of Huh-7 cells with PCMV6-AXL was confirmed by western blot, using antibodies against AXL or the fusion Myc tag (A). Huh-7 cells overexpressing AXL induced a stronger but more transient phosphorylation of STAT1 (B), with increased phosphorylation at 15 and 30 minutes post-IFN (50 u/ml), but a strong decrease at 1 h (2 replicates). …”

Evaluation of MGMT inhibitors with chemosensor 1. by Andrew A. Beharry (1940068)

“…<p>Incubation of purified MGMT enzyme with the inhibitors BG and PaTrin-2 led to a concentration dependent decrease in observed final fluorescence intensity, indicative of MGMT inhibition. …”

RNA degrades with time. by Jeffrey A. Blair (3178230)

“…(C) An antibody to rRNA shows a similar decrease of immunoreactivity with time, (D) but an antibody to dsDNA remains robust even after a PMI of 46 h. …”

Therapeutic efficacy study in <i>E</i>. <i>granulosus</i> infected mice. by Julia A. Loos (737868)

“…<p>(A) Box plots showing the comparative distribution of the weight (g) of cysts recovered from untreated mice (C) and treated with albendazole (ABZ, 5 mg/kg/d), metformin (Met, 50 mg/kg/d) and the combination of both drugs (ABZ+Met) for 60 days. …”

Summary of the physiological, metabolic and hypothalamic gene expression changes in exercising Siberian hamsters with free access to a running wheel compared to sedentary Siberian... by Ines Petri (531427)

Ouabain block of the Na⁺/K⁺ pump switches Purkinje cell activity out of the trimodal firing pattern and into a continuous burst mode. by Michael D. Forrest (292801)

“…In this case, the only deflections observed are those of the Ca²⁺ spikes that have travelled into the soma from the dendritic arborisation (<i>E</i>, <i>I</i>). <i>Panel A scaling is encoded in the first scale bar (50 mV, 50 s). …”

Table 1_Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transpla... by Tatiana A. Rudakova (20945432)

“…Secondary endpoints included the cumulative incidence of a 25% decrease in serum lactate dehydrogenase levels and to the limit of the normal range for age from the date of the initiation of eculizumab, the cumulative incidence of a 50% increase in platelet count or stable platelet levels ≥ 20×10⁹/l was 74% (95% CI, 32–92) with median time 21 days (range: 1–104), cumulative incidence of platelet level ≥ 50×10⁹/l, and 1 year from the date of the initiation of eculizumab.…”

Image_1_Biosynthesis of Silver Nanoparticles by Marine Actinobacterium Nocardiopsis dassonvillei and Exploring Their Therapeutic Potentials.jpg by Maha A. Khalil (11454121)

“…In vitro studies using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay revealed a concentration-dependent decrease in cell viability when CaCo2 cells were exposed to Bio-AgNPs. …”

The effect of (A) mean sequencing depth (genome coverage) and (B) average number of nucleotide differences per site (<i>π</i>) on accuracy of genetic similarity estimates in simula... by Kevin D. Murray (759583)

Simplified diagrammatic representation of our mathematical model. by Cyrill A. Rentsch (117042)

“…A more detailed version of this figure is provided by the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056327#pone.0056327.s001" target="_blank"><b>Figure S1</b></a> of the supplemental material.…”

Effect of PMI on cytoskeletal proteins. by Jeffrey A. Blair (3178230)

“…Scale bars = 50 μm. (B) However, by Western blot, while the proteins actin and GAPDH show no correlation with PMI times, detectable tubulin levels decrease significantly after a PMI of 22 h. …”

The canonical pathway of NF-κB activation is required for TNF-α and IL-1β stimulated eotaxin and MCP-1 gene expression in gingival fibroblasts. by Elisabeth A. Boström (495490)

“…<p><b>(A)</b> Time-dependent decrease of IκBα protein in gingival fibroblasts exposed to TNF-α (50 ng/ml) and IL-1β (100 pg/ml) cultured for 5, 10, 15 and 30 min. …”

Timeline depicting the harvest history of sage-grouse from 1870s–2019 stratified by sage-grouse Management Zone and greater and Gunnison sage-grouse populations. by Jonathan B. Dinkins (11478180)

Table 4_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx by Tien Le (634791)

Table 5_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx by Tien Le (634791)

Table1_Alterations in circulating lipidomic profile in patients with type 2 diabetes with or without non-alcoholic fatty liver disease.docx by Assim A. Alfadda (9674998)

μCT analysis of extra-osseous extension of primary osteosarcoma. by Heather A. Cole (571670)

Large-scale mutagenesis of p7 has little impact on infectious virus production. by Margaret A. Scull (369144)

“…The secondary structure boundaries shown were previously deduced from p7 NMR data using HCV-J (genotype 1b) in 50% TFE [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005297#ppat.1005297.ref041" target="_blank">41</a>]. …”

EWS/FLI-1 siRNA and R1507 block Ewing's sarcoma cell proliferation by inhibiting a shared pathway: phosphorylation of IGF-1R and Akt. by Helen J. Huang (201553)