Dissolving microneedle patches for transdermal delivery of paroxetine: <i>in-vitro, ex-vivo</i> studies and its PBPK modeling by Muhammad Sikandar (13449684)

“…</p> <p>MNPs from the optimized formulation successfully created microchannels in rat skin, demonstrated higher permeation than control MNPs with a flux of 146.18 ± 13.42 µg/cm²/h, presented a decrease in lag phase and an increase in drug plasma C_max and AUC compared to PAXIL CR 12.5 mg oral, and showed higher stability in the room and refrigerator conditions.…”

Labeling efficiency of FE-Pro. by Mya S. Thu (370201)

“…MRI conditions: 7.0 Tesla, Gradient-Echo sequence, voxel size = 0.09 mm³, TR/TE = 5402.5/90 ms. Scale bars = 50 µm (A), 2 µm (B) and 200 nm (C).</p>…”

Table_5_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.docx by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

Single stranded DNA extension analysis of MutL binding activity. by Jonghyun Park (237480)

“…<p>(<b>A</b>) A 5.3 kb ssDNA is coiled randomly at a stretching force of 2.5 pN. …”

Patterns of lake ice cover are changing throughout the Northern Hemisphere. by Alessandro Filazzola (6631649)

“…Depending on the greenhouse gas emissions, we predict a loss of between 50,000 and 200,000 km² of ice cover. …”

Slug controls mammosphere growth. by Mayssa Nassour (109073)

“…Microspheres and mammospheres were reported separately after 3 weeks. A significant decrease in viability was observed after 3 days in cells transfected with anti-Slug siRNA. …”

Table_2_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.DOCX by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

Validation of the model predictions for mES cell colony-forming efficiencies confirm enhanced self-renewal at reduced oxygen levels with GSK-3 inhibition. by Hélder S. C. Barbosa (158982)

“…Heat-maps show relative expression levels of key pluripotency genes (c), and colonies were stained for Nanog (d.1) or Oct4 (d.2) and nuclear marker DAPI (scale bar: 50 µm). The positive effects of GSK-3 inhibition could be correlated with a decrease in total and phosphorylated protein levels at 20% and 2% O₂ (e). …”

Supplementary Material for: Renoprotection by Continuous Erythropoietin Receptor Activator in Puromycin Aminonucleoside-Induced Nephrotic Syndrome by Aizawa K. (4135771)

“…<b><i>Background/Aims:</i></b> Recent studies have demonstrated that erythropoiesis-stimulating agents (ESAs) induce a tissue-protective effect in the kidney. In this study, we examined whether continuous erythropoietin receptor activator (CERA), a long-acting ESA, could prevent kidney injury, especially podocyte damage, in a rat model of nephrotic syndrome induced by puromycin aminonucleoside (PAN). …”

Influence of the conservation status on carbon balances of semiarid coastal Mediterranean wetlands by Daniel Morant (8748285)

“…Specifically, a highly altered site showed increased rates of aerobic respiration compared to undisturbed sites, with a decrease in C storage capacity to ∼50  g m⁻² yr⁻¹. …”

Table_1_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.docx by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

ProBDNF collapses neurite length <i>in vitro</i> through p75NTR. by Ying Sun (23237)

“…C, proBDNF decreased neurite length on DRG neurons in a dose-dependent manner. …”

Mithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors by Eléonore Otjacques (410361)

“…In rat aortic ring assays, a strong anti-angiogenic effect was seen, which could be explained by a decrease of VEGF production and an up-regulation of anti-angiogenic proteins such as IP10 after MTM treatment. …”

Table_3_Metagenomic-based characterization of the gut virome in patients with polycystic ovary syndrome.XLSX by Liansha Huang (13252590)

“…</p>Results<p>The gut virome of PCOS patients exhibited a significant decrease in within-sample viral diversity and a remarkable alteration of the overall virome composition compared with that of healthy controls. …”

Image_2_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.TIFF by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

Group I PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells by Kateřina Kuželová (541883)

“…IPA-3 induced cell death with EC50 ranging from 5 to more than 20 μM. Similar range was found for IPA-3-mediated dephosphorylation of a known PAK downstream effector, cofilin. …”

Humic substances and its distribution in coffee crop under cover crops and weed control methods by Bruno Henrique Martins (7368752)

“…Data showed that humic substances comprised about 50 % of SOM. Although different cover crops and weed control methods did not alter humic and fulvic acid carbon content, a possible incidence of condensed aromatic structures at depth increments in fulvic acids was observed, leading to an average decrease of 53 % in the E4/E6 ratio. …”

Image_2_Heat in Wheat: Exploit Reverse Genetic Techniques to Discover New Alleles Within the Triticum durum sHsp26 Family.PDF by Alessia Comastri (5767751)

“…According to the last FAO report, a dramatic decrease in wheat production is expected in the next decades mainly due to the upcoming climate change. …”

Table_3_Dissimilatory Sulfate Reduction Under High Pressure by Desulfovibrio alaskensis G20.DOCX by Adam J. Williamson (1343514)

“…Dose-response experiments showed a twofold decrease in the sensitivity of D. alaskensis to the antibiotic chloramphenicol at 14 MPa. …”

GHG emission accounts in the GLOBIOM model for agriculture and land use change by H Valin (557174)

“…Our results confirm that yield increase could mitigate some agriculture-related emissions growth over the next decades. Closing yield gaps by 50% for crops and 25% for livestock by 2050 would decrease agriculture and land use change emissions by 8% overall, and by 12% per calorie produced. …”