A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of Ca_V2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca²⁺ In... by Maria Isabel Bahamonde (840859)

“…ΔF1502 strongly decreases the voltage threshold for channel activation (by ~ 21 mV), allowing significantly higher Ca²⁺ current densities in a range of depolarized voltages with physiological relevance in neurons, even though maximal Ca²⁺ current density through ΔF1502 Ca_V2.1 channels is 60% lower than through wild-type channels. …”

Hydroxyl Defects in LiFePO₄ Cathode Material: DFT+<i>U</i> and an Experimental Study by Dmitry A. Aksyonov (4918594)

“…The P occupancy decrease is explained by the formation of hydrogarnet-like P/4H and P/5H defects, which have the lowest formation energies among all considered OH defects. …”

Apoptosis is enhanced in DCE- or CS-treated keratinocytes. by Claudia Scarponi (205759)

Effect of partial Glo-I inhibition by EP on LPS-induced production of TNF-α, collagen-I and α-SMA in HSC. by Marcus Hollenbach (376231)

“…Presence of LPS and treatment with low-level concentrations of MGO (indicating partial inhibition of Glo-I activity without complete enzyme inhibition) showed significant decrease of LPS-induced release of TNF-α (absence vs. presence of 10mM MGO: 371.8±22.7 vs. 60.9±11.2 pg/ml; p<0.001), collagen-I (10.0±0.3 vs. 1.8±0.5 ng/ml; p<0.001) and α-SMA (68.6±3.6 vs. 43.8±2.2 ng/ml; p<0.001) <b>(A2, B2, C2)</b>. …”

Effects of 20 μM 5-aza-dC Treatment on the 10q25 Neocentromere by Nicholas C Wong (14627)

“…Six CpG islets (28, 31, 69, 70, 71, and 101) showed an increase in DNA methylation upon the formation of the 10q25 neocentromere. However, following 5-aza-dC treatment, the methylation level of these CpG islets decreased significantly. …”

Temporal microstructure of dyadic social behavior during relationship formation in mice by Won Lee (3554000)

“…We found that subordinates decrease their tail rattling and aggressive behavior in response to aggressive but not subordinate behavior exhibited by dominants and that tail rattling in particular may function to deescalate aggressive behavior in pairs. …”

Hel2 and Asc1 attenuate gene expression from stall-containing mRNAs only at high initiation rates. by Heungwon Park (3859507)

MXene/Bi₂O₃ Nanocomposites as Supercapacitors for Portable Electronic Devices by Nanasaheb M. Shinde (8560572)

LM11A-31's effect on cholinergic dystrophic neurites in cortex of mid-stage APP^L/S mice. by Danielle A. Simmons (621167)

“…Scale bar in photomicrograph A = 50 µm. Quantitative analysis showed that LM11A-31 decreases the total area occupied by the clusters (<b><i>C</i></b>) by decreasing their number (<b><i>D</i></b>) but not the mean area per cluster (<b><i>E</i></b>). …”

Representative data from primary HTS. by Pamela Y. Ting (713174)

Working model for REG-O3 mechanism of action. by Rodrick Montjean (400649)

Interferon induced protein 35 exacerbates H5N1 influenza disease through the expression of IL-12p40 homodimer by Anshu P. Gounder (626041)

“…The host Interferon Induced Protein 35 (Ifi35) has been implicated in increased susceptibility to H5N1-IAV infection. Here, we show that Ifi35 deficiency leads to reduced morbidity in mouse models of highly pathogenic H5N1- and pandemic H1N1-IAV infection. …”

Effects of COS on the expression of MCP-1 and iNOS mRNA in RGC-5 cells. by I-Mo Fang (470460)

“…<p>RGC-5 cells were stimulated with 0.5mM PQ and then treated with 50 μg/ml (low-dose) or 100 μg/ml (high-dose) COS for 12 hours. …”

Plot of adjusted risk ratios of high SARS-CoV-2 viral load upon presentation to the emergency department for each study day compared to the first day of the study that includes an... by Michael J. Satlin (9160569)

Sensitivity of U251 stable clones to GCV. by Elizabeth Wei-Chia Luo (11250668)

“…<p>U251, U251-pCMV-HSVtk, and U251-pGFAP-HSVtk cells were treated with 0, 1, 5, or10 μg/ml of GCV for 5 days. (A–D) Live-cell phase images of U251 parent cells displayed no cytotoxicity up to 10 μg/ml of GCV. …”

Phase Behavior and Structural Characterization of Ionic Clathrate Hydrate Formed with Tetra‑<i>n</i>‑butylphosphonium Hydroxide: Discovery of Primitive Crystal Structure by Takayuki Kobori (1556734)

Expression of Glo-I and MGO in whole rat liver. by Marcus Hollenbach (376231)

3D spheroids enhance NFAT3 and CXCR4 expression. by Keven Huang (675616)

“…(<b>C</b>) Corresponding to the increase in NFAT3 in 3D spheroids, real-time PCR showed a 30-50-fold increase in CXCR4 mRNA in 3D spheroids when compared to adherent HeyA8 cells. (*, P <0.05 vs Adh, 1-way ANOVA). …”

Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells by Mi-Sun Lim (5665255)

“…This was done using γ-irradiated noggin-overexpressing CF1-mouse embryonic fibroblasts (MEF-noggin) and MS5 stromal cells (MS5-noggin and MS5-sonic hedgehog). …”

Table_5_Do Organic Substrates Drive Microbial Community Interactions in Arctic Snow?.XLSX by Benoît Bergk Pinto (7592897)