Discovery of Novel Substituted <i>N</i>‑(4-Amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide Analogues as Potent Human Adenovirus Inhibitors by Jimin Xu (2208961)

“…Notably, among these derivatives, compound <b>15</b> showed improved anti-HAdV activity (IC₅₀ = 0.27 μM), significantly decreased cytotoxicity (CC₅₀ = 156.8 μM), and low <i>in vivo</i> toxicity (maximum tolerated dose = 150 mg/kg in hamster) as compared with niclosamide, supporting its further <i>in vivo</i> efficacy studies for the treatment of HAdV infections.…”

Passenger mutations accurately classify human tumors by Marina Salvadores (6589187)

“…In particular, introducing the RMD features into a combined classification model increased the fraction of diagnosed patients by 50 percentage points (at 20% FDR). …”

CREB Targets Define the Gene Expression Signature of Malignancies Having Reduced Levels of the Tumor Suppressor Tristetraprolin by Mohammad Fallahi (200679)

“…These analyses defined a signature of 50 genes differentially regulated between high and low <i>TTP</i>-expressing tumors. …”

Bootstrapped LIWC positive word ratio (LWPR) around the hit date for each hurricane and location. by Krishna Bathina (12883820)

Maximum deformation variation of buried DN50 PE pipeline with different stacking loads. by Pengcheng Li (123281)

Aggrecan knockdown ATDC5 chondroprogenitor cells have decreased Alcian blue staining and absorbance levels compared to control cells after ITS stimulation. by Juanita K. Hodax (6848540)

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 by Marta E. Capala (652765)

“…Downregulation of SAM50 also impaired the proliferation and replating capacity of BCR-ABL-expressing cells, again associated with a decreased mitochondrial membrane potential. …”

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy by Maude Giroud (2017114)

“…When tested in vivo, compound <b>7</b> showed efficacy after oral dosing in a mouse model of peripheral nerve injury by decreasing plasma neurofilament light (NfL) levels at 50 mg/kg compared with vehicle-treated control mice, holding promise for the treatment of neurodegenerative and neurological disorders.…”

Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial by Michel Mandro (2637532)

“…<div><p>Introduction</p><p>Recent findings from onchocerciasis-endemic foci uphold that increasing ivermectin coverage reduces the epilepsy incidence, and anecdotal evidence suggests seizure frequency reduction in persons with onchocerciasis-associated epilepsy, when treated with ivermectin. We conducted a randomized clinical trial to assess whether ivermectin treatment decreases seizure frequency.…”

Bootstrapped LIWC negative word ratio (LWNR) around the hit date for each hurricane and location. by Krishna Bathina (12883820)

Bootstrapped VADER sentiment around each hurricane and location. by Krishna Bathina (12883820)

Fluid loss and hydration in CON (n = 22) and HOT (n = 17) surgeries; Decrease in body mass in kg (A), decrease in body mass in % of total body mass (B), rate of decrease in body ma... by Zehra Palejwala (7507409)

Effect of melatonin (50 μM) on the TGF-β1 (10 ng/mL, 72 h)-mediated TGF-β1/Smad pathway and EMT in HBdSMCs. by Yang Zhang (30734)

Thermophoresis-Controlled Size-Dependent DNA Translocation through an Array of Nanopores by Miao Zhang (17216)

“…Large arrays of nanopores can be used for high-throughput biomolecule translocation with applications toward size discrimination and sorting at the single-molecule level. In this paper, we propose to discriminate DNA length by the capture rate of the molecules to an array of relatively large nanopores (50–130 nm) by introducing a thermal gradient by laser illumination in front of the pores balancing the force from an external electric field. …”

Towards Automated Annotation of Benthic Survey Images: Variability of Human Experts and Operational Modes of Automation by Oscar Beijbom (767233)

“…Digital photography enables rapid collection of survey images to meet this need, but the subsequent image annotation is typically a time consuming, manual task. We investigated the feasibility of using automated point-annotation to expedite cover estimation of the 17 dominant benthic categories from survey-images captured at four Pacific coral reefs. …”

Representative immunofluorescence images for S100A6 in brainstem structures in control and stressed mice. by Katarzyna Bartkowska (453261)

Representative immunofluorescence images for S100A6 in some brain structures related to stress responses. by Katarzyna Bartkowska (453261)

Confocal images of brain sections immunostained with S100A6 and vimentin antibodies. by Katarzyna Bartkowska (453261)

Parasite Load Decrease during Application of a Safe and Easily Applied Antileishmanial Aminoglycoside Cream by Afif Ben Salah (202439)

GASP mutants initially reach a high population density and subsequently decrease population viability. by Felix J. H. Hol (475373)