Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

VPS34 inhibition decreases intracellular levels of cholesteryl-esters, blocks cholesterol uptake and enhances lysosomal degradation of LDLR. by Marek J. Kobylarz (9292599)

Summary plot for the effect of important food sources of fructose-containing sugars on diastolic blood pressure (DBP). by Qi Liu (33068)

Bmi1 Essentially Mediates Podocalyxin-Enhanced Cisplatin Chemoresistance in Oral Tongue Squamous Cell Carcinoma by Yueying Zhou (450705)

“…On the other hand, knockdown of PODXL significantly decreased the Bmi1 expression level and cisplatin IC50 and increased cisplatin-induced cell apoptosis, which was completely reversed by overexpression of Bmi1. …”

Intravenous treatment of naïve wild-type mice with PrP LSPCs decreased PrP^C mRNA and cell surface PrP^C protein at various time points. by Heather Bender (363996)

Src-induced tyrosine phosphorylation of Kv2.1 in CHO cells is significantly decreased in Kv2.1(S800A) mutants. by Kai He (157282)

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta–analysis by Thomas Benichou (5047928)

“…Included articles had to report HRV parameters in T2DM patients and healthy controls measured during 24 hours with a Holter–electrocardiogram. Measurements of HRV retieved were: RR–intervals (or Normal to Normal intervals—NN), standard deviation of RR intervals (SDNN), percetange of adjacent NN intervals differing by more than 50 milliseconds (pNN50), square root of the mean squared difference of successive RR intervals (RMSSD), total power, Low Frequency (LF), High Frequency (HF) and LF/HF ratio, as per Task Force recommendations.…”

Summary plot for the effect of important food sources of fructose-containing sugars on systolic blood pressure (SBP). by Qi Liu (33068)

S3 File - by Andrei Rajkovic (10965915)

National contributions to urban sprawl (2014), weighted sprawl per capita (2014), and to the respective changes (1990–2014) at the scale of a global 50 × 50 km² grid. by Martin Behnisch (7285397)

Despair by age UK, UKHLS, 2009–2021. by David G. Blanchflower (8011427)

DataSheet1_Capsaicin suppresses ciliary function, while inducing permeability in bronchial epithelial cell cultures of COPD patients.docx by Halil Ibrahim Toy (10533263)

“…Formoterol significantly prevented decreases in CBF induced by capsaicin. Higher concentrations of capsaicin (250-500 μM) significantly reduced TEER of BECs from nonsmokers (T2-T24 h), smokers (T24 h) and COPD patients (T2 and T24 h), which was partially prevented by roflumilast. …”

Kato-Katz storing experiment: Absolute median fecal egg counts (FEC) change over time for (A) hookworm (n = 67 for room temperature, n = 62 for refrigerator), (B) <i>A</i>. <i>lumb... by Felix Bosch (10024550)

Quantitative analyses of ROS levels in IPEC-J2 cells incubated for 2 hours (2A, 2B), 24 hours (2C, 2D) and 48 hours (2E, 2F) with inhibitor MI-432 at different concentrations (10,... by E. Pászti-Gere (816855)

Injury-induced cold sensitization in <i>Drosophila</i> larvae involves behavioral shifts that require the TRP channel Brv1 by Heather N. Turner (6157268)

Decrease in number of activated macrophages in demyelinated nerves subjected to 1hr ES. by Nikki A. McLean (643606)

“…Note: ES results in a significant decrease in the ED-1 IF 10d post-LPC (5d post-ES; K) and 12d post-LPC (7d post-ES; N) relative to LPC only in a pattern suggestive of movement toward lateral edges and egress (arrow). …”

Table_1_Warmer Temperatures Affect the in situ Freezing Resistance of the Antarctic Vascular Plants.DOCX by Angela Sierra-Almeida (839647)

“…<p>Although positive effects on growth and reproduction of Antarctic vascular plants have been reported under warmer temperatures, it could also increase the vulnerability of these plants to freezing. Thus, we assessed in situ whether warming decreases the freezing resistance of Colobanthus quitensis and Deschampsia antarctica, and we compared the level and mechanism of freezing resistance of these species in the field with previous reports conducted in lab conditions. …”

Effects of insecticides, fipronil and imidacloprid, on the growth, survival, and behavior of brown shrimp <i>Farfantepenaeus aztecus</i> by Ali Abdulameer Al-Badran (7485437)

“…The effects of six concentrations of fipronil (0.0, 0.005, 0.01, 0.1, 1.0, and 3.0 μg/L) and six concentrations of imidacloprid (0.0, 0.5, 1.0, 15.0, 34.5, 320.0 μg/L) were tested in a laboratory. We examined five different endpoints: growth, moulting interval, survivorship, behavioral change, and body color change. …”

AR negative triple negative or “quadruple negative” breast cancers in African American women have an enriched basal and immune signature by Melissa Davis (3522224)

“…AR-negative patients have a (66.60; 95% CI, 32–146) odds ratio of being basal-like compared to other PAM50 subtypes, and this is associated with an increased time to progression and decreased overall survival. …”

Breeding Guild Determines Frog Distributions in Response to Edge Effects and Habitat Conversion in the Brazil’s Atlantic Forest by Rodrigo B. Ferreira (835774)

“…In Brazil’s Atlantic Forest, we evaluated frog richness and abundance by breeding guild at four distances from the edge of a reserve: i) 200 m inside the forest, ii) 50 m inside the forest, iii) at the forest edge, and iv) 50 m inside three different converted habitats (coffee plantation, non-native <i>Eucalyptus</i> plantation, and abandoned pastures, hereafter matrix types). …”