Analysis of the MMS RIT-seq screen. by Jennifer A. Stortz (4268842)

“…</b> Scatter plots showing the ratio of mapped RNAi target-specific reads for every gene (grey dots) in the RNAi-induced, MMS-treated population relative to the RNAi-induced, untreated population (MMS+/MMS-); gene location within the 11 megabase chromosomes is shown and dotted lines indicate 2-fold increase and decrease in MMS+/MMS- ratio. Genes are highlighted with roles in (A) homologous recombination (HR, red), mismatch repair (MMR, blue) and nucleotide excision repair (NER, green), or in (B) intraflagellar transport (IFT, red), mitochondrial replication (Mito rep, blue) and encoding histones (green). …”

Structure–Kinetics Correlations in Isostructural Crystals of α‑(<i>ortho</i>-Tolyl)-acetophenones: Pinning Down Electronic Effects Using Laser-Flash Photolysis in the Solid State... by Anoklase J.-L. Ayitou (1906648)

“…Notably, the rate for δ-hydrogen atom transfer of <b>1a</b> (2.7 × 10⁷ s^–1) in the crystalline phase is 18-fold larger than that of <b>1b</b> (1.5 × 10⁶ s^–1). …”

A degradation debt? Large-scale shifts in community composition and loss of biomass in a tropical forest fragment after 40 years of isolation by Rakan A. Zahawi (530432)

“…A 2.25-ha permanent plot was established in the center of the old-growth forest (>400 m to nearest edge boundary) and all plants >5 cm DBH were censused, mapped, and identified to species in two surveys taken ~5–6 years apart (>3,000 stems/survey). …”

Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis by Usha Katragadda (386668)

“…Compared with the free drugs at equivalent doses, intravenous administration of paclitaxel/17-AAG-loaded micelles led to 3.5- and 1.7-fold increase in the tumor concentrations of paclitaxel and 17-AAG, respectively, without significant altering drug levels in normal organs. …”

Figure S1 - Immune Responses and Hypercoagulation in ERT for Pompe Disease Are Mutation and rhGAA Dose Dependent by Sushrusha Nayak (371224)

“…Arrows indicate fold decrease over corresponding 20 mg/kg time point. p<0.05 *, p<0.005 **, p<0.0005 ***, ns = not significant.…”

Engineering <i>Trichoderma reesei</i> for the hyperproduction of cellulose induced protein 1 (Cip1) on a sophorose-containing inducer to efficiently saccharify alkali-pretreated co... by Jianghong Li (4221922)

“…For <i>T. reesei</i> OE-cip1-1 and OE-cip1-2, the hydrolysis efficiency increased by 25.0 and 28.6% with a solid loading of 5% at 2 h, respectively. Simultaneously, 85.5 and 85.2 g/L glucose were released using a cellulase cocktail at high solid loading (20%), and these glucose release rates were significantly greater than that of <i>T. reesei</i> Rut C30 cellulase (77.4 g/L) at 120 h. …”

Effect of bone morphogenetic protein-2 (BMP-2) overexpression on mRNA levels of extracellular matrix molecules and proteoglycan (PG) synthesis by Esmeralda N Blaney Davidson (39198)

“…Cycle threshold values were first corrected for and then for the viral control, after which the fold increase/decrease was calculated. Decreases in mRNA levels compared with controls are on the negative scale. …”

SRM measurements of a subset of <i>C. jejuni</i> metabolic enzymes. by Xiaoyun Liu (154889)

“…</p>4<p>Spectral counts obtained for the same biological replicate.</p>5<p>Fold change of peptide spectral counts between the 2 h and 20 h samples; negative values denote decreased levels in the 20 h samples.…”

Image_3_A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.jpeg by Federica Mangili (10146332)

“…Accordingly, S2152D FLNA expression abolished the expected ability of BIM53097 to increase or decrease, in MMQ and in AtT20 respectively, ERK phosphorylation, an effect that was maintained in S2152A FLNA expressing cells (+1.8 ± 0.65-fold, p < 0.05 in MMQ; -55 ± 13%, p < 0.01 in AtT-20). …”

Image_1_A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.jpeg by Federica Mangili (10146332)

“…Accordingly, S2152D FLNA expression abolished the expected ability of BIM53097 to increase or decrease, in MMQ and in AtT20 respectively, ERK phosphorylation, an effect that was maintained in S2152A FLNA expressing cells (+1.8 ± 0.65-fold, p < 0.05 in MMQ; -55 ± 13%, p < 0.01 in AtT-20). …”

Image_2_A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation.jpeg by Federica Mangili (10146332)

“…Accordingly, S2152D FLNA expression abolished the expected ability of BIM53097 to increase or decrease, in MMQ and in AtT20 respectively, ERK phosphorylation, an effect that was maintained in S2152A FLNA expressing cells (+1.8 ± 0.65-fold, p < 0.05 in MMQ; -55 ± 13%, p < 0.01 in AtT-20). …”

Purification and Characterization of the Fe^II- and α-Ketoglutarate-Dependent Xanthine Hydroxylase from <i>Aspergillus nidulans</i>^† by Gabriela M. Montero-Morán (2493271)

“…The αKG cosubstrate can be substituted with α-ketoadipate (9-fold decrease in <i>k</i>_cat and 5-fold increase in the <i>K</i>_m compared to those of the normal α-keto acid), while the αKG analogue <i>N</i>-oxalylglycine is a competitive inhibitor (<i>K</i>_i = 0.12 μM). …”

Reduced VEGF disrupts the parenchyma around airways and vasculature. by Minna M. Wieck (849372)

“…<i>White and black arrows</i> point to magnified areas shown in insets. Scale bars represent 50 μm. Data are expressed as mean ± SD, *P< 0.05, **P< 0.01 versus control.…”

The effect of stretch on the MAP of the fish heart. by Simon M. Patrick (364948)

“…MAPD is shown at MAPD25 (A,D), MAPD50 (B,E) and MAPD90 (C,F) (mean ± S.E.M, <i>p</i><0.05). …”

Independent model predictions versus experimental observations. by Ryan Tasseff (253998)

“…The ensemble predicted an approximate 50% decrease in androgen stimulated PSA expression due to AR knock-down 72 hours after treatment. …”

SINGLE PORT LAPAROSCOPIC CHOLECYSTECTOMY: TECHNICAL ASPECTS AND RESULTS by Murillo de Lima FAVARO (5670416)

“…Conversion to open surgery occurred in three cases (1.76%). The mean surgical time was 67.97 min, showing a marked decrease when was reached close to 50 cases and a stabilization after 100 surgeries. …”

CA and HT abolished the <i>in vivo</i> obesogenic effect of RGZ. by Esmail Lutfi (848005)

“…Exposure to 1 μM RGZ induced a significantly smaller decrease in adiposity compared with CT. The effect of RGZ was abolished by CA 50 μM (A) and HT (100 μM) (B). …”

BMC Neuroscience-5 by Javier A Bravo (19963)

“…Upper microphotograph shows a 40× magnification (scale bar = 50 μm). The middle microphotographs show details of the same field at 100× magnification (scale bar = 20 μm). …”

Perifosine targets the Aldefluor-positive cell population in breast cancer xenografts. by Hasan Korkaya (159560)

“…<p>(A–C). 50,000 cells from SUM159 cell line or two breast cancer xenografts, MCI, or UM2 were injected into NOD/SCID mice and the tumor size was monitored. …”

Effect of signaling pathway inhibitors on ox-LDL-induced Klotho downregulation in proximal tubular cells. by Cristina Sastre (503532)

“…<p>Pretreatment of MCT with parthenolide (1 µM) or PD098059 (50 µM) for 1 hour attenuates the decrease in Klotho mRNA (<b>A</b>) and protein (<b>B</b>) induced by ox-LDL (25 µg/mL). …”