C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Further mechanism studies showed that inhibiting C5aR1 by PMX53 protected the rats from MCAO/R injury, decreased cell inflammation, and apoptosis via inhibiting the TLR4 and NF-κB signaling pathway and reducing the production of TNF-α, IL-1β, and IL-6 in MCAO/R rats. …”

Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study by Kelly Fellows Maxwell (6852752)

“…</p><p>Results</p><p>FSS scores decreased from a baseline of 5.51 (95% CI: 4.86, 6.16) to a mean of 3.03 (95% CI: 2.23, 3.82) at 12 months (p < 0.001). …”

Hydrogen volume fraction distribution at different pressures (a) 1 MPa; (b) 3 MPa; (c) 5 MPa. by Weiqing Xu (1279959)

Additional file 5 of ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy by Lihong Lu (10532648)

“…(D) Compared with the control group, sh-KMT5A decreasedCD31 mRNA expression in HUVECs. (E) Compared with the control group,sh-KMT5A increased vimentin mRNA expression in HUVECs. …”

Relative mRNA levels of DNA methyltransferases (<i>Dnmt1</i>, <i>Dnmt3a</i>, and <i>Dnmt3b</i>; a) and microRNAs (<i>mir-29b</i>, <i>mir-148a</i>, and <i>mir-152</i>; b) in porcine... by Shuang Liang (211832)

Upregulation of miR-30a-5p resulted in promotion of glioblastoma cell growth that was reversed partially by Ad-S7. by Zhifan Jia (286723)

“…<p>(A) The figure showed that 30a-5p m increased the cell survival rate at a significantly higher rate in SNB19 cells and LN229 cells, (B) accelerated the glioma cells from G0/G1 to S phase in SNB19 cells and LN229 cells, (C) decreased the apoptotic cells in the 30a-5p m group, (D) promoted the cell invasive ability. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

A R13A point mutation in C4 attenuates CLCuMuV infection. by Asigul Ismayil (5698946)

“…<b>(C)</b> The mutant CLCuMuV carrying C4^R13A (CLCuMuV-C4^R13A), which contains a R13A mutation in <i>C4</i>, showed the decreased viral symptom compared to wild type CLCuMuV. …”

HDACi-resistant HCT-R cells exhibit high expression levels of pAKT, a downstream effector of WNT5A and ROR2. by Michael Bordonaro (340595)

“…Cells were exposed to 1.5 mM 5-FU for 24 hrs, and apoptotic assays were performed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027308#s4" target="_blank">Materials and Methods</a>. …”

Response curves of T/F and chronic viruses to CD4 and CCR5 expression levels. by Yiying Zhang (198443)

Natural populations of flies that carry the major temperate haplotype (T/T/C/A) manifest decreased daytime sleep compared to the major tropical haplotype (C/A/T/T). by Yong Yang (63842)

Comparison of True Simulated Incidence Rate (Grey Lines) and Estimates Using Either Method (Black Lines; Both Give Same Results) when True Incidence Increases Steadily (A), Decreas... by Timothy B Hallett (42782)

hMDA-7 BSA-NPs decrease pancreatic tumor volumes in BXPC-3 and PANC-1 xenografts. by Qingyun Zhu (4497790)

DA receptor agonist pramipexole reduces generosity reference-point (V). by Sergio Oroz Artigas (8207559)

Effect of irradiation on claudin-5 immunostaining in mouse brain endothelial cells. by Nikolett Sándor (659792)