Design of <i>N</i>‑Benzoxaborole Benzofuran GSK8175Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor by Pek Y. Chong (1833568)

“…We previously described the discovery of GSK5852 (<b>1</b>), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which an <i>N</i>-benzyl boronic acid was essential for potent antiviral activity. …”

<i>C</i>. <i>auris</i> induces IL-1Ra in macrophages to decrease the neutrophil function in the skin. by Abishek Balakumar (20189865)

CrGluCl-T318A expression in <i>Xenopus</i> oocytes. by Isabel Cornejo (634494)

“…Average with SEM of spontaneous currents in CrGluClα-T318A-expressing oocytes (n = 7), and increase in current evoked by 100 µM glutamate (n = 7), and the current decrease upon addition of ivermectin (n = 4) or emamectin (n = 5). …”

The scaled cells after manufacturing with a 3D PLA printer. by Shokouh Dezianian (17145036)

The optimized fatigue example: (a) vertical layering and (b) horizontal layering. by Shokouh Dezianian (17145036)

Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage by Isobel J. Whitehouse (331843)

“…Contactin 5 (CNTN5) has also been implicated in the development of AD by a genome-wide association study. …”

Main results using crosswalk between EQ-3D-5L and EQ-3D-3L for Chile. by Raimundo Atal (18272064)

The B-Raf^V600E-Twist axis regulates miR-10b expression in melanoma. by Ila Datar (433874)

Response of a Habitat-Forming Marine Plant to a Simulated Warming Event Is Delayed, Genotype Specific, and Varies with Phenology by Laura K. Reynolds (318282)

“…In this study, we examined the immediate effects of a moderate warming event of 4.5°C lasting 5 weeks and the legacy effects after a 5 week recovery on different genotypes of the marine plant <i>Zostera marina</i> (eelgrass). …”

Inhibition of RIP1 or MLKL decreases morbidity and mortality during <i>S</i>. <i>marcescens</i> hemorrhagic pneumonia. by Norberto González-Juarbe (836747)

Physiological characterization of rice <i>m167</i> plants. by Xuexia Wang (3701098)

IRE1 depletion decreases heterochromatin, DNA and H3K9me3 methylation, and UHRF1. by Iratxe Zuazo-Gaztelu (21071939)

Treatment with BMP-7 decreases expression of M1 macrophage marker, iNOS, as well as pro-inflammatory cytokines. by Crystal Rocher (500661)

“…Histogram <b>C</b> shows quantitative analysis of expression of IL-6 with a significant decrease in the ACM+BMP7 group; n = 5–6. …”

Endline data availability and patient sample sizes by HealthRise site and for intervention and comparison patients. by Nancy Fullman (243628)

Phenotype of Ad5-specific CD8⁺ T-cells. by Natalie A. Hutnick (234410)

“…<p>Five seronegative (Ad5 nAb titer ≤18, gray circles) and five seropositive subjects (Ad5 nAb titer >18, white circles) received Merck Ad5 gag/pol/nef as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0014385#s2" target="_blank">Methods</a>. …”

Summary of key themes, components, and quotes from qualitative data synthesized across US HealthRise sites. by Nancy Fullman (243628)

Unadjusted and adjusted difference-in-difference regression results, by HealthRise grantee, for hypertension (A) and diabetes (B) patients. by Nancy Fullman (243628)

Percentage of HealthRise patients meeting hypertension and diabetes disease severity categories between baseline and endline, by site. by Nancy Fullman (243628)

Baseline and endline measures by HealthRise site and for intervention and comparison patients for hypertension (A) and diabetes (B). by Nancy Fullman (243628)

Overview of interventions by US HealthRise site. by Nancy Fullman (243628)