Proliferative potential decreases and <i>p16</i> transcripts increase in the presence of PGE₂ and iso-PGE₂. by Jennifer P. Chou (576226)

IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors by Alexandra Cousido-Siah (777034)

“…Starting from the potent AR inhibitor IDD388, we have synthesized a series of derivatives bearing the same halophenoxyacetic acid moiety with an increasing number of bromine (Br) atoms on its aryl moiety. Next, by means of IC₅₀ measurements, X-ray crystallography, WaterMap analysis, and advanced binding free energy calculations with a quantum-mechanical (QM) approach, we have studied their structure–activity relationship (SAR) against both enzymes. …”

Long-term, Western diet (WD)-fed PIF1 KO female mice exhibited decreased locomotor activity and whole-body energy expenditure. by Frances R. Belmonte (6743618)

PPARγ inhibition decreased effects of MAG incubation on PPARγ expression and insulin-stimulated signaling pathway in human umbilical vein endothelial cells. by Xiangyan Liang (431205)

Stability diagram in the plane for plane-wave propagation through a mural slice of our 2D simulation domain with a random distribution of myocytes and fibroblasts. by Rupamanjari Majumder (128411)

Stability diagram in the plane for plane-wave propagation through a transmural slice of our 2D simulation domain with a random distribution of myocytes and fibroblasts. by Rupamanjari Majumder (128411)

Preserved NSS at 2 and at 24 hours following ischemia and decreased infarct volume in PAR1 KO mice 24 hours following ischemic stroke. by Efrat Shavit-Stein (3186678)

“…(C) Total infarct volume is significantly lower in PAR1 KO mice compared to control (t-test, WT = 6, PAR1 KO = 6). (D) Infarct volume decreases as a function of distance from the ischemic core (slices #5&6). …”

Α-Difluoromethylornithine (DFMO) (2% per orally in drinking water) decreases polyamine levels in mammary fat pad tumors of MDA-MB-231 cells by Monica M Richert (63671)

Data_Sheet_1_Overexpression of MsASMT1 Promotes Plant Growth and Decreases Flavonoids Biosynthesis in Transgenic Alfalfa (Medicago sativa L.).docx by Huifang Cen (5077895)

“…<p>Melatonin (N-acetyl-5-methoxytryptamine) is a pleiotropic signaling molecule that plays important roles in plant growth, development and stress responses. …”

Activation of the glucocorticoid receptor increases expression of the MKP-1/DUSP1 gene and decreases IL-1β-stimulated p38 MAPK phosphorylation. by Susan J. Burke (130329)

Effect of costunolide and BIBR1532 on AFP secretion by HepG2/C3A and PLC/PRF/5 cell lines. by Roula Tahtouh (714734)

“…The supernatant was then collected for ELISA. (A) Costunolide (5–50 μM) significantly decreased AFP production in a dose-dependent manner in the supernatants of HepG2/C3A cells after 48 h of treatment, whereas 50 μM costunolide decreased the AFP levels in the supernatant of PLC/PRF/5 cells. …”

Decreased glycosylated α-DG and laminin levels distal to the glial dome in <i>Large</i>^{<i>myd/myd</i>} mice. by Shigefumi Morioka (8893511)

Decreased expression levels and/or mislocalization of MYO6 and stereociliary taper-specific proteins in the hair cells of <i>ksv</i>/<i>ksv</i> mice. by Yuta Seki (4385833)

“…A similar decrease in the cuticular plates was observed in the utricle hair cells of <i>ksv/ksv</i> mice (E) and in IHCs stained with the anti-MYO6 (N-ter) antibody (F). …”

Decreased expression of 14-3-3 θ, β, γ, and Chk1 protects against Vpr- and HIV-1 (-)-induced cell cycle arrest by Diane L Bolton (92098)

Supplementary Material for: Vitamin D₃ Treatment Decreases Frequencies of CD16-Positive and TNF-α-Secreting Monocytes in Asthmatic Patients by Grubczak K. (4152079)

“…Interestingly, we found that a combined treatment of 1,25-(OH)₂D₃ and GC allowed for a 5-fold reduction of the GC dose while maintaining their anti-inflammatory effects. …”

Deficiency of G1 regulators P53, P21and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest-2 by Sharon Sheahan (38663)

“…As for all experiments the -null hepatocytes were obtained by infection at the time of plating of the hepatocytes of corresponding genotypes with adenovirus expressing Cre recombinase. (1) all deficient hepatocytes respond less well to inhibition of proliferation by TGFβ than control cells and deficient has the strongest effect. (2) and deficiency, singly or together have a similar effect on inhibition of proliferation by TGFβ. (3) deletion significantly reduces TGFβ-induced cell cycle arrest regardless of and status (compare control with ; - with with - and with TRPL). (4) double deficiency in and further decreases hepatocytes responses to TGFβ in term of regulation of proliferation, independently of status. (5) by contrast the effect of TGFβ on hepatocytes deficient in both and is not significantly different to that of null cells, and this is independent of status. …”

Data_Sheet_1_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.docx by Dengpan Bu (369549)

Alcohol decreases NETosis and NET-mediated bacterial killing in mouse bone marrow-derived neutrophils in response to <i>S</i>. <i>aureus</i> infection. by Liliang Jin (4443058)

DataSheet_1_Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients.docx by Emilio Nuñez-Borque (17301673)

“…Extracellular vesicles (EVs) were characterized by Western blot, electron microscopy and NanoSight. A decrease of miR-375-3p levels was determined by qPCR in both serum and EVs of patients with anaphylaxis (****p<.0001). …”

Datasheet1_Quality of life, exercise capacity, cognition, and mental health of Chilean patients after COVID-19: an experience of a multidisciplinary rehabilitation program at a phy... by Valeria Paéz (17523354)

“…Moreover, physical therapy led to a reduction in neuropathic symptoms and pain, psychological therapy reduced anxiety and depression, and language therapy enhanced memory and speech (all p < 0.05). (3) Demographic and clinical history characteristics did not predict responses to rehabilitation. (4) A regression model for predicting changes in SF-36 total score, based on physical function, physical role, general health, and mental health, was established based on the data from study (p < 0.01, adjusted R² = 0.893). (5) Classification models for predicting dropouts achieved 68% accuracy, with key predictors of treatment adherence including diabetes, hypertension, and dyslipidemia, Tinetti balance, physical role, and vitality of SF36, and performance on the 6-minute walk test and 1-minute sit-to-stand.…”