Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence by Zachary J. Farino (2156665)

“…Further, we showed that bromocriptine, a known dopamine D2/D3 receptor agonist and newly approved drug used for treatment of type II diabetes mellitus, also decreased glucose-stimulated insulin secretion in islets to levels comparable to those caused by dopamine treatment.…”

Loss of UPF proteins directly decreases the degradation of <i>cat-3</i> mRNA and indirectly increases <i>cat-3</i> gene transcription through elevating <i>cpc-1</i> mRNA stability. by Shuangjie Shen (12800414)

Jatrophane Diterpenoids from <i>Euphorbia glomerulans</i> by Aobulikasimu Hasan (6448166)

“…Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds <b>11</b> (IC₅₀ value of 5.0 ± 0.8 μM) and <b>12</b> (IC₅₀ value of 5.2 ± 2.0 μM) possessed MDR reversal activities that were as good as that of verapamil (IC₅₀ value of 4.7 ± 0.6 μM).…”

Jatrophane Diterpenoids from <i>Euphorbia glomerulans</i> by Aobulikasimu Hasan (6448166)

“…Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds <b>11</b> (IC₅₀ value of 5.0 ± 0.8 μM) and <b>12</b> (IC₅₀ value of 5.2 ± 2.0 μM) possessed MDR reversal activities that were as good as that of verapamil (IC₅₀ value of 4.7 ± 0.6 μM).…”

Jatrophane Diterpenoids from <i>Euphorbia glomerulans</i> by Aobulikasimu Hasan (6448166)

“…Several compounds showed different chemoreversal activities and considerably decreased cytotoxicity. Compounds <b>11</b> (IC₅₀ value of 5.0 ± 0.8 μM) and <b>12</b> (IC₅₀ value of 5.2 ± 2.0 μM) possessed MDR reversal activities that were as good as that of verapamil (IC₅₀ value of 4.7 ± 0.6 μM).…”

The Bax and BCL-2 gene expressions. by Laleh Pourmousavi (17675254)

The concentration of serum oxidative stress markers in the study groups. by Laleh Pourmousavi (17675254)

The concentration of oxidative stress markers in heart tissue. by Laleh Pourmousavi (17675254)

Data_Sheet_1_The dynamic transcriptome during maturation of biofilms formed by methicillin-resistant Staphylococcus aureus.docx by Jelle Vlaeminck (13166814)

“…The clfA gene, which encodes clumping factor A, was the single common DEG identified across the three clones in 24-h biofilm culture (2.2- to 2.66-fold). In intermediate (48 h) and late (72 h) stages of biofilms, decreased expression of central metabolic and fermentative pathways (glycolysis/gluconeogenesis, fatty acid biosynthesis), indicating a shift to anaerobic conditions, was already evident in USA300 and HEMRSA-15 in 48-h biofilm cultures; ST239 showed a similar profile at 72 h. …”

S1 Data - by Arjen Tilstra (6915227)

The bifunctional pT2K-CAG-EGFP-183F plasmid expresses functional members of the miR-183 family <i>in vitro</i>. by Kaidi D. Zhang (770061)

“…(C) miRNAs produced from pGFP-183F bind to their complementary targets to decrease luciferase activity. The miRNA reporters, composed of two complementary miRNA binding sites (to either miR-183, miR-96, or miR-182) housed downstream of the <i>Renilla</i> luciferase gene, were co-transfected into DF-1 cells with pGFP-183F or pGFP. …”

X-Ray Psoralen Activated Cancer Therapy (X-PACT) - Fig 3 by Mark Oldham (2577727)

“…<b>B:</b> in CT2A cells, X-PACT cytotoxicity increases with X-ray dose (0, 0.67 and 1.00 Gy respectively), concentration of 8-MOP psoralen (10, 20 and 40 μM respectively), and phosphor (50 and 100 μg/ml) respectively. …”

Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes by Sulav Duwal (152805)

“…Combining the population pharmacokinetics of DTG with the stochastic framework, we predicted that plasma concentrations of 145.18 and 722.23nM prevent 50- and 90% sexual transmissions respectively. …”

Outline of study participants. by Shahrzad Daei (20565172)

“…</p><p>Conclusion</p><p>The results of this study suggested that higher adherence to the healthy component of GDQS and lower intake of the unhealthy component decreased the risk of T2D incidence.</p></div>…”

DataSheet1_Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatmen... by Ziqiang Li (247218)

“…Potential drug interaction mechanisms were revealed by assessing the effects of PCE on the activity and expression of multiple transporters, including OAT1/3, OCT2, MDR1, and BCRP.</p><p>Results: Concurrent use of PCE substantially reduced circulating CIP (approximately 40%–50%) in humans and rats, while CIP hardly changed circulating GA and PCA. …”

Pollution Characteristics of Particulate Matter (PM2.5 and PM10) and Constituent Carbonaceous Aerosols in a South Asian Future Megacity by Aslam, Afifa

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MMP-2 activity. by Taynara Aparecida Vieira (16401726)

Concentration of suspended solids (mg /l) in six concentrations of water turbidity. by Javier Manjarrez (531011)

Relative expression of collagen III/β-actin. by Taynara Aparecida Vieira (16401726)

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment-3 by Iliya Lefterov (73826)

“…Note that unlike in WT cells, GW does not decrease the expression of iNOS and IL-6 in dko cells. …”