Image_2_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.TIF by Dengpan Bu (369549)

Flow chart for the enrolled patients. by Kyu Jin Lee (18143946)

“…Left ventricular (LV) function was categorized as either normal LV ejection fraction (LVEF ≥ 50%) or decreased LVEF (<50%).</p><p>Results</p><p>Among the 1,194 patients with septic shock, 392 (32.8%) who underwent echocardiography within 24 h of time zero were included in the final analysis (normal LVEF: n = 246; decreased LVEF: n = 146). …”

Flow chart of performed HLA class II typing in T1DM population. by Silvia Ricci (450811)

Elimination of the MRC rescues the prophase I delay due to constitutive Rad51 activation, while decreasing spore viability and increasing MI nondisjunction. by Andrew Ziesel (9422868)

Effect of inhibitory antibodies and human serum on NA enzymatic function ELLA and NA Star. by Harrison Powell (9040128)

Local sensitivity analysis of procoagulants, fibrin, F1.2 flux, and TAT flux. by Jason Chen (15937)

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Schematic of the reduced model. by Jason Chen (15937)

Illustration of the difference between the IC50 value assessed directly from experimental data and model-based deconvolution of mechanisms explaining downstream inhibition. by Jennifer L. Wilson (6061124)

“…In the proposed modeling framework, it is possible to separate effects on a specific cell type, from propagated effects, such as loss of upstream progenitors. …”

Cell cycle accumulation at G2/M in MTDH knockdown Hec50co cells at 24 hours after LBH589 or LBH589 and TRAIL treatment. by Xiangbing Meng (200278)

“…<p>(A) Cell cycle profiles were determined in control or MTDH knockdown Hec50co cells at 24 hours after treatment with 20 nM LBH589, 25 ng/ml TRAIL, or LBH589 and TRAIL in combination. …”

The potency of the blockage of FXIa varies over the subsets of fibrin concentration. by Jason Chen (15937)

Local sensitivity analysis of total thrombin, free, and bound thrombin in the clot. by Jason Chen (15937)

Plasma protein levels and thrombin binding sites distribution of the subsets of top and bottom 2% of fibrin concentration of 10,000 simulations. by Jason Chen (15937)

H-MSCs^WT prevent hypoxia induced cardiac fibroblast activation, but leptin deficit inhibit this effect. by Panpan Chen (307628)

RNA sequencing linkage analysis identifies a single base pair change on Chromosome 25 that is tightly linked to the <i>escapist</i> hypersensitive phenotype. by Elelbin A. Ortiz (8655285)

Video example of a boundary vector cell. by Lear Cohen (15353793)

The Effect of Added Ligands on the Reactions of [Ni(COD)(dppf)] with Alkyl Halides: Halide Abstraction May Be Reversible by Megan E. Greaves (9353706)

“…Sterically bulky and electron-donating ligands are found to decrease the reaction rate. It was found that (i) the halide abstraction step is not always irreversible and the subsequent recombination of a nickel­(I) complex with an alkyl halide can have a significant effect on the overall rate of the reaction and (ii) some ligands lead to very stable [Ni­(dppf)­(L)₂] species. …”

Oxidation of L-[1-¹⁴C]Cys as a percentage of dose in enterally fed piglets receiving graded levels of Cys and 0.25 g kg^-1 d^-1 Met. by Anna K. Shoveller (6208457)

Tun impairs alveolarization in NOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…The decreased radial alveolar counts (RAC; 2.9±0.5 <i>vs</i> 4.8±0.7, n = 11, 5 males and 5 females each group, p<0.001) (<b>A</b>), increased mean linear intercepts (MLI; 77.8±6.8 μm <i>v</i>.…”