Theoretical Studies on the Mechanism, Enantioselectivity, and Axial Ligand Effect of a Ru(salen)-Catalyzed Asymmetric Cyclopropanation Reaction by Ting Shi (3955)

“…Five proposed reaction pathways, including (1) a stepwise process containing the formation of carbene species and cyclopropanation step (path a), (2) a one-step process (path b), (3) a bis-carbene mechanism (path c), (4) a three-centered-intermediate pathway (path d), and (5) the main side reaction of dimerization of EDA (path e), are taken into consideration to determine the most favorable mechanism. …”

Defects in the conduction of somatosensory evoked potentials of median and tibial nerves in a healthy child and in H-ABC patient. by Jose R. Eguibar (8563227)

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

High-dose thiamine prevents brain lesions and prolongs survival of <i>Slc19a3</i>-deficient mice by Kaoru Suzuki (4217638)

“…To investigate the molecular mechanisms of neurodegeneration in SLC19A3 deficiency and whether administration of high-dose thiamine prevents neurodegeneration, we generated homozygous Slc19a3 E314Q knock-in (KI) mice harboring the mutation corresponding to the human SLC19A3 E320Q, which is associated with the severe form of THMD2. …”

Simulated average monthly flow at the 10 outflow assessment nodes in the five river basins over the 2008 to 2020 period (HMRB: Harirod-Murghab River Basin, HRB: Helmand River Basin... by Fazlul Karim (7225826)

Statistical criteria for the number of clusters. by Dong Yoon Lee (1594840)

“…New dementia (N = 2664) was developed during follow-up period (2010–2015). Five hemoglobin trajectories were identified: high, mid, low, increasing, and decreasing. …”

SEM images of lattice scaffolds; A) 4 layers, B) 6 layers, C) 8 layers, D) 10 layers, and staggered scaffolds; E) 4 layers, F) 6 layers, G) 8 layers, H) 10 layers. by Zahra Yazdanpanah (10038944)

Position of committed effective dose <i>E</i>_U+LS between <i>E</i>_LS and <i>E</i>_U (Bq d^–1). by Martin Šefl (11607984)

A complete set of mathematical model equations utilized in ILYCM software to develop S. <i>frugiperda</i> phenology for each life stage. by Marian Adan (16641634)

Fig 2 - by Muhammad Imran Nisar (10226212)

Individual serotype carriage rates over the study period. by Muhammad Imran Nisar (10226212)

The carriage rate of VT serotypes by number of doses of vaccine. by Muhammad Imran Nisar (10226212)

Serotype specific carriage rate from 2014–18 in Matiari, Pakistan. by Muhammad Imran Nisar (10226212)

Serotype-specific carriage rate by vaccination status. by Muhammad Imran Nisar (10226212)

Pre-diabetes is associated with increased risk of heart failure among patients with atrial fibrillation by Jia-Yi Huang (12733928)

“…Compared to those who remained pre-diabetic, patients who progressed to diabetes were associated with an increased risk of HF (SHR=1.50, 95% CI: 1.13-1.97), whereas those who reversed to normoglycaemia were associated with decreased risk (SHR=0.61, 95% CI: 0.42-0.94). …”

VAN-exposed lineages exhibited a fitness tradeoff in the presence and absence of vancomycin. by Samuel E. Blechman (19506884)

“…<p>(<b>A-F</b>) Shown are growth parameters of cycle 50 VAN-exposed lineages relative to ancestral VRSA strains (dotted horizontal lines), as measured in the presence (<b>A-C</b>; 32 μg/ml) and absence (<b>D-F</b>) of vancomycin. …”

Camel blood cell area and its relation to NaCl concentrations and incubation times. by Hasan Alhaddad (106573)

DataSheet1_A Two-step Strategy for High-Value-Added Utilization of Rapeseed Meal by Concurrent Improvement of Phenolic Extraction and Protein Conversion for Microbial Iturin A Prod... by Meng Wang (124646)

“…The antioxidant and antibacterial activities of phenolic extracts were influenced by both total phenolic content and profile, while microbial feedstock value of residue was greatly improved because protein content was increased by ∼5% and phenolic content was decreased by ∼60%. …”

Ablative RT increased CD47 expression in tumors. by Elham Rostami (339949)

Knockdown of IFI27 impairs LCL survival <i>in vitro</i> and <i>in vivo</i>. by Ken Sagou (1945318)