DAF-16/FOXO is Required for Locomotory Healthspan and Lifespan Benefits of Genetic Glycolysis Disruption. by Brian Onken (86790)

“…<i>daf-16</i> mutants are documented to have lowered locomotory ability vs. WT later in life [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.ref091" target="_blank">91</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.ref092" target="_blank">92</a>]; we note that, although comparison of scores across experiments is not possible due to variation in baseline values, the swimming rate of <i>daf-16(mgDf50)</i> control animals was slightly lower than WT controls on the same day of life (in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008982#pgen.1008982.g001" target="_blank">Fig 1C</a>; mean of 46.17 head thrashes/30 sec. for <i>daf-16</i> vs. 52.17 head thrashes/30 sec. for WT on day 10). …”

3D representation of MeV infected cells realized with IMARIS 9.9.1. by Pierre Khalfi (7868252)

Subjects:

Graphic representation of the SARS-CoV-2 testing outcome of 10,014 nasopharyngeal swabs. by William R. Webb (13046882)

Barbie’s ankle equinus measured at 50 degrees as equnius posture (a) and flat foot posture measured at 0 degrees (b), with a handheld goniometer. by Cylie Williams (3446018)

Correlation between protein abundances and R_5-20 z-score among cases at baseline. Protein abundances, normalized to mean 0 and variance 1, are displayed on the y-axis. (... by Spela Kokelj (8356644)

The mean number of the emerged <i>D. melanogaster</i> adults. Mean number (±SE) of emerged adults and average percentage (±SE) of the residual fertility at the different treatment... by Flavia Cerasti (21655934)

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Genetic deletion of Bin1 in neurons leads to a reduction in survival but not to neuronal loss in PS19 Hemi or Ncar mice. by Kathleen M. McAvoy (7224863)

Fig 7 - by Finn Egil Skjeldestad (7821716)

Subjects:

A flowchart describes the stepwise analysis of missense SNPs in the human PC and illustrates the computational tools used in the study. by Mahvash Farajzadeh-Dehkordi (17468232)

Parameters for the seven ODE models. by Hope Murphy (8843516)

The numerical values underlying Fig 4. by Wataru Matsunaga (3452621)

“…However, only the KO mice showed a significant decrease in rotarod performance of 1.2 g/kg EtOH. …”

Development of hiPSC-derived β-cells organoids and the effect of leucettines on the insulin production. by Barbara Pucelik (2988795)

IC₅₀ (left) and <i>ε</i>_max (right) measurement time dependence for all seven models. by Hope Murphy (8843516)

No change in muscle size and force, but a decrease in TB mass in 1-mo Lmna^HSA-cko mice. by Lei Xiong (334812)

Elementary Steps in Olefin Metathesis: Nickelacyclobutanes via Cycloaddition to Nickel Carbenes by Samantha K. Cormier (16872384)

Transient convection-diffusion of thrombin into and out of a fibrin domain exposed to venous flow. by Jason Chen (15937)

The inhibitory activity of the most active compounds against Glo-I enzyme with less than 50 µM. Their supportive corresponding docking values on two different protocols are display... by MohammedBashar Al-Qazzan (22439236)

Loss of RBM-26 function causes a reduction in the density of mitochondria in the PLM axon. by Tamjid A. Chowdhury (14149846)