A Novel Highly Potent Autotaxin/ENPP2 Inhibitor Produces Prolonged Decreases in Plasma Lysophosphatidic Acid Formation <i>In Vivo</i> and Regulates Urethral Tension by Hiroshi Saga (584103)

“…To date, several autotaxin/ENPP2 inhibitors have been reported; however, none were able to completely and continuously inhibit autotaxin/ENPP2 <i>in vivo</i>. In this study, we report the discovery of a highly potent autotaxin/ENPP2 inhibitor, ONO-8430506, which decreased plasma lysophosphatidic acid formation.…”

Porcupine plots of the PCA analysis depicting the movement and altitude of the C-alpha atoms throughout the 50 ns simulation in the native and mutant complexes. by Sneha P. (3926957)

Decreased phagocytosis of <i>Y. pestis</i> in bone marrow derived macrophages (BMMs) and neutrophils (BMNs) from <i>Irf3^−/−</i> mice. by Ami A. Patel (149580)

<i>P. brasiliensis</i>-infected mice treated with CFA present remarkable decrease of fungal burden and increase of cytokines production. by Leandro Licursi de Oliveira (374413)

A: Top, representative recording of the application, for 10 seconds, of different concentrations of tribendimidine which produces a depolarization (upward movement of the thickest... by Alan P. Robertson (362793)

Estimated mean lichen species richness vs. distance to the DMTS haul road in Cape Krusenstern National Monument, Alaska, on a log-log scale from a Bayesian posterior predictions mo... by Peter N. Neitlich (4034300)

Subjects:

The percent of students who, if a science instructor were to tell a joke about a specific subject, might find the joke funny and might find the joke offensive. by Katelyn M. Cooper (5634851)

Alterations in fat body Lsd1 and Lsd2 levels upon the genetic increase or decrease in cardiac Snail TF levels. by Ying Liu (18461)

IC₅₀ of indole alkaloid against lipase [23]. by Atikarn Janthongkaw (17020498)

Means for global competence pre- and post-test scores. by Esther Kim (2996622)

Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia by Mary E. Irwin (293687)

“…In two human Ph+ALL cell lines, inhibition of ErbB kinase activity with canertinib resulted in a dose-dependent decrease in the phosphorylation of an ErbB kinase signaling target p70S6-kinase T389 (by 60% in Z119 and 39% in Z181 cells at 3 µM). …”

MBIC50 and MBEC50 values (µg/mL) of synthesized 1,2,3,5-tetrazine derivatives against bacteria pathogen strains. by Jean Paul Dzoyem (6424445)

Subjects:

LS-PGC-1β^−/− mice exhibit decreased expression of TCA and ETC enzymes and mtDNA content. by Kari T. Chambers (106919)

Pairwise correlations of excitatory neurons in APP/PS1 mice are decreased in dCA1, but increased in vCA1. by Udaysankar Chockanathan (18510288)

Decreased dendritic spine density and mEPSC amplitude in the DG of Arf4^+/− mice compared to WT mice. by Sachi Jain (108277)

Increased body weight and decreased expansion of pro-inflammatory CD4+ T-cells from blood in Tg-HD5 rats. by Osiris Marroquin Belaunzaran (224031)

Mitochondrial enzyme ALAS1 interacts with MeV-V protein. by Pierre Khalfi (7868252)

Subjects:

IODVA1 inhibits lamellipodia and circular dorsal ruffle (CDR) formation in MDA-MB-231 cells and decreases Rac activation. by Anjelika Gasilina (8566296)

S1 File - by Chantelle M. de Vet (16535257)

“…The student’s RV-GLS consistency was poor during the first 25 measurements, moderate-to good during the second 25 measurements and again poor-to-moderate during the final 50 measurements. Repeated measurements analysis showed a significant decrease in variability of the LV- and RV-GLS score differences between the expert and trainees over time (<i>p</i>_adj<0.001), which was not significantly different between trainees. …”

Inhibition of PI3K activity decreases uptake of Opa_CEA-expressing gonococci via CEACAM1. by Maike Voges (154488)