Largazole (L) and largazole ester (E) inhibit ubiquitin E1 in a dose dependent manner <i>in vitro</i>. by Dana Ungermannova (334910)

“…In addition, DMSO has no effect on the formation of the thioester linkage as seen in lane 2 of both gels. 50 nM E1 was incubated with decreasing concentrations of L (A) or E (C) for 15 minutes at room temperature followed by addition of a cocktail containing ATP and Ub-F. …”

Table 1_Propolis supplementation on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis of randomized controlled trials.docx by Hossein Bahari (16704768)

“…This meta-analysis revealed that propolis consumption led to a significant decrease in C-reactive protein (CRP) (WMD: –1.23; 95%CI: –1.76, –0.69; p < 0.001), Interleukin-6 (IL-6) (WMD: –1.52; 95%CI: –2.10, –0.93; p < 0.001), Tumor necrosis factor-α (WMD: –1.15; 95%CI: –1.75, –0.55; p < 0.001), and Monocyte chemoattractant protein-1 (MCP-1) (WMD: –35.33; 95%CI: –50.28, –20.37; p < 0.001), and a significant increase in total antioxidant capacity (TAC) (WMD: 0.32; 95%CI: 0.12, 0.51; p = 0.001), Glutathione (GSH) (WMD: 4.71; 95%CI: 3.17, 6.25; p < 0.001), and Glutathione peroxidase (GPx) (WMD: 44.75; 95%CI: 5.10, 84.40; p = 0.02). …”

Supplementary Material for: A Systematic Review and Meta-Analysis of Molecular Biomarkers Associated with Early Neurological Deterioration Following Acute Stroke by Martin A.J. (6051545)

“…After classification into 3 broad categories, meta-analysis showed that biomarkers associated with increased END risk (n; fixed-effects mean difference; 95% CI) were “metabolic” (glucose [<i>n</i> = 9,481; 0.90 mmol/L; 0.74–1.06], glycosylated haemoglobin [<i>n</i> = 3,146; 0.33%; 0.19–0.46], low-density lipoprotein [<i>n</i> = 4,839; 0.13 mmol/L; 0.06–0.21], total cholesterol [<i>n</i> = 4,762; 0.21 mmol/L; 0.11–0.31], triglycerides [<i>n</i> = 4,820; 0.11 mmol/L; 0.06–0.17], urea [<i>n</i> = 1,351; 0.55 mmol/L; 0.14–0.96], decreasing albumin [<i>n</i> = 513; 0.33 g/dL; 0.05–0.61]); “inflammatory and excitotoxic” (plasma glutamate [<i>n</i> = 688; 60.13 µmol/L; 50.04–70.22], CSF glutamate [<i>n</i> = 369; 7.50 µmol/L; 6.76–8.23], homocysteine [<i>n</i> = 824; 2.15 µmol/L; 0.68–3.61], leucocytes [<i>n</i> = 3,766; 0.54 × 10⁹/L; 0.34–0.74], high-sensitivity C-reactive protein [<i>n</i> = 1,707; 3.79 mg/L; 1.23–6.35]); and “coagulation/haematological” (fibrinogen [<i>n</i> = 3,132; 0.32 g/L; 0.25–0.40]; decreasing haemoglobin [<i>n</i> = 3,586; 2.38 g/L; 0.15–4.60]). …”

Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique by Anna E. Phillips (4050331)

“…<i>haematobium</i> was seen in adults even in the SBT arms implying the rate of transmission in the community had been decreased, even where only school children have been treated, which has significant logistical and cost-saving implications for a national control programme in justifying CWT.…”

Table_2_Dietary intervention improves metabolic levels in patients with type 2 diabetes through the gut microbiota: a systematic review and meta-analysis.XLSX by Xiaoyu Xu (356293)

“…In comparison to baseline measurements, the high-fiber diet produced substantial reductions in FBG (mean difference −1.15 mmol/L; 95% CI, −2.24 to −0.05; I² = 94%; P = 0.04), HbA1c (mean difference −0.99%; 95% CI, −1.93 to −0.03; I² = 89%; P = 0.04), and total cholesterol (mean difference −0.95 mmol/L; 95% CI, −1.57 to −0.33; I² = 77%; P = 0.003); the high–fat and low–carbohydrate diet led to a significant reduction in HbA1c (mean difference −0.98; 95% CI, −1.50 to −0.46; I² = 0%; P = 0.0002). …”

Table_1_Dietary intervention improves metabolic levels in patients with type 2 diabetes through the gut microbiota: a systematic review and meta-analysis.DOCX by Xiaoyu Xu (356293)

“…In comparison to baseline measurements, the high-fiber diet produced substantial reductions in FBG (mean difference −1.15 mmol/L; 95% CI, −2.24 to −0.05; I² = 94%; P = 0.04), HbA1c (mean difference −0.99%; 95% CI, −1.93 to −0.03; I² = 89%; P = 0.04), and total cholesterol (mean difference −0.95 mmol/L; 95% CI, −1.57 to −0.33; I² = 77%; P = 0.003); the high–fat and low–carbohydrate diet led to a significant reduction in HbA1c (mean difference −0.98; 95% CI, −1.50 to −0.46; I² = 0%; P = 0.0002). …”

Table_1_Dietary intervention improves metabolic levels in patients with type 2 diabetes through the gut microbiota: a systematic review and meta-analysis.DOCX by Xiaoyu Xu (356293)

“…In comparison to baseline measurements, the high-fiber diet produced substantial reductions in FBG (mean difference −1.15 mmol/L; 95% CI, −2.24 to −0.05; I² = 94%; P = 0.04), HbA1c (mean difference −0.99%; 95% CI, −1.93 to −0.03; I² = 89%; P = 0.04), and total cholesterol (mean difference −0.95 mmol/L; 95% CI, −1.57 to −0.33; I² = 77%; P = 0.003); the high–fat and low–carbohydrate diet led to a significant reduction in HbA1c (mean difference −0.98; 95% CI, −1.50 to −0.46; I² = 0%; P = 0.0002). …”

Table_2_Dietary intervention improves metabolic levels in patients with type 2 diabetes through the gut microbiota: a systematic review and meta-analysis.XLSX by Xiaoyu Xu (356293)

“…In comparison to baseline measurements, the high-fiber diet produced substantial reductions in FBG (mean difference −1.15 mmol/L; 95% CI, −2.24 to −0.05; I² = 94%; P = 0.04), HbA1c (mean difference −0.99%; 95% CI, −1.93 to −0.03; I² = 89%; P = 0.04), and total cholesterol (mean difference −0.95 mmol/L; 95% CI, −1.57 to −0.33; I² = 77%; P = 0.003); the high–fat and low–carbohydrate diet led to a significant reduction in HbA1c (mean difference −0.98; 95% CI, −1.50 to −0.46; I² = 0%; P = 0.0002). …”

Supplementary Material for: The value of circulating tumor DNA in the prognostic diagnosis of bladder cancer: a systematic review and meta-analysis by figshare admin karger (2628495)

“…PLR and NLR were 2.8 (95% CI: 1.24-6.35) and 0.43 (95% CI: 0.28-0.65), respectively, with a DOR of 6.56 (95% CI: 2.12-20.33).Fagan plot analysis showed that the posterior probability of a positive result rose to 74% and the posterior probability of a negative result decreased to 30% when the prior probability was 50%. …”

Correlating exhaled aerosol images to small airway obstructive diseases: A study with dynamic mode decomposition and machine learning by Jinxiang Xi (518144)

“…While the performance of RF constantly increased with the number of features retained, the performance of SVM peaked at 50 and decreased thereafter. The 5-class classification accuracy was 94.8% using the DMDC-RF model and 93.0% using the DMD-RF model, both of which were higher than 87.0% in the previous study that used fractal dimension features.…”

Data_Sheet_1_Age-specific risk factors for the prediction of obesity using a machine learning approach.pdf by Junhwi Jeon (14434233)

Data_Sheet_2_A Competitive Advantage of Middle-Sized Diatoms From Increasing Seawater CO2.xlsx by Qi Zhang (28502)

Table_1_Cost-Effectiveness of Lifestyle-Related Interventions for the Primary Prevention of Breast Cancer: A Rapid Review.pdf by Martine Bellanger (4101313)

“…The median cost-effectiveness ratio (in 2018 USD) was $24,973, and 80% of the interventions had a ratio below the $50,000 threshold. The low-fat-diet program for postmenopausal women was cost-effective at a societal level, and the physical activity interventions, such as the Be Active Program in the UK, had the best cost saving results. …”

Table_3_Cost-Effectiveness of Lifestyle-Related Interventions for the Primary Prevention of Breast Cancer: A Rapid Review.pdf by Martine Bellanger (4101313)

“…The median cost-effectiveness ratio (in 2018 USD) was $24,973, and 80% of the interventions had a ratio below the $50,000 threshold. The low-fat-diet program for postmenopausal women was cost-effective at a societal level, and the physical activity interventions, such as the Be Active Program in the UK, had the best cost saving results. …”

Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review by Sawmmiya Kirupaharan (18144475)

“…Of the 32 patients with both pre- and posttreatment pain scores, there was a significant decrease from 40.0 (IQR = 5.5–71.8) to 15.0 (IQR = 3.5–53.8; <i>P</i> = 0.037). …”

Table_2_Cost-Effectiveness of Lifestyle-Related Interventions for the Primary Prevention of Breast Cancer: A Rapid Review.pdf by Martine Bellanger (4101313)

“…The median cost-effectiveness ratio (in 2018 USD) was $24,973, and 80% of the interventions had a ratio below the $50,000 threshold. The low-fat-diet program for postmenopausal women was cost-effective at a societal level, and the physical activity interventions, such as the Be Active Program in the UK, had the best cost saving results. …”

ORF63 does not affect STAT2 activation but promotes IRF9-degradation. by Marieke C. Verweij (357813)

Datasheet1_MRI visibility and displacement of elective lymph nodes during radiotherapy in head and neck cancer patients.pdf by Floris C. J. Reinders (14049621)

“…Background and purpose<p>To decrease the impact of radiotherapy to healthy tissues in the head and neck region, we propose to restrict the elective neck irradiation to elective lymph nodes at risk of containing micro metastases instead of the larger lymph node volumes. …”

Neo-Innominate Vein Creation Using Left Internal Jugular Vein in a Complex Dialysis-Dependent Pediatric Patient by Maxwell F. Kilcoyne (8693666)

An ice-obligate seabird responds to a multi-decadal decline in Arctic sea ice - age and state demographic parameters by George Divoky (17982751)

“…<p dir="ltr">The Arctic has experienced greatly decreased sea ice and increased ocean temperatures in recent decades but there is a paucity of biological time-series data allowing assessment of resulting temporal variation in the region’s marine ecosystems. …”