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point decrease » point increase (Expand Search)
we decrease » _ decrease (Expand Search), nn decrease (Expand Search), teer decrease (Expand Search)
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11741
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11742
The conserved phenylalanine residue in PRMT5 is critical for inhibition by the five compounds.
Published 2017“…D, The F225M mutation in PRMT5 decreased the IC<sub>50</sub> values of the compounds, as determined by quantitation and analysis of methylation assay results.…”
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11743
Antimicrobial activity of RP-1 peptide conjugate with ferrocene group
Published 2020“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC<sub>50</sub> = 0.63 μmol L<sup>-1</sup>), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”
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11744
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11745
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11746
Gizzard erosions in broiler chickens in Sweden caused by fowl adenovirus serotype 1 (FAdV-1): investigation of outbreaks, including whole-genome sequencing of an isolate
Published 2022“…The investigation included whole viral genome sequencing and investigation of genomic organization and sequence relationships with other adenoviruses. All five flocks had a history of decreased growth and uneven size of birds since 9-10 days of age. …”
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11747
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo
Published 2024“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC<sub>50</sub> = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”
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11748
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo
Published 2024“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC<sub>50</sub> = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”
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11749
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11750
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11751
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11752
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11753
Datasheet1_Delayed acquisition of airway commensals in antibiotic naïve children and its relationship with wheezing in rural Ecuador.docx
Published 2023“…Most of the core and accessory organisms increased in abundance and prevalence with age, except for a few which decreased. At 7 months of age, infants with wheeze had notably higher levels of a single Streptococcus operational taxonomic unit and core microbiota member than controls.…”
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11754
Table1_Effectiveness of dapagliflozin as an insulin adjunct in type 1 diabetes: a semi-mechanistic exposure-response model.DOC
Published 2023“…Even so, this association remained flat, with a 50% decrease in the basal insulin dose from pretreatment level, resulting in ∼5% increase in glucose exposure. …”
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11755
DataSheet1_Extracellular cyclophilins A and C induce dysfunction of pancreatic microendothelial cells.pdf
Published 2022“…All these effects were reversed by pre-treatment with cyclosporine A. eCyps also produced endothelial dysfunction, as evidenced by the decrease in eNOS activation. …”
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11756
Equilibrium relationships between genetic diversity and parasite prevalence.
Published 2021“…The variation in <i>r</i><sup>2</sup> as a function of sample size is indicated by point size. …”
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11757
Representative cases.
Published 2015“…Case 2: 62-year-old female patient, DM duration 7 years, HbA<sub>1c</sub> 9.4%, NDS 5 points; Wagner 2 (d), advanced non-proliferative DR (e), moderate decrease in confocal SBP parameters (NFD = 0.010 μm/μm<sup>2</sup>) (f). …”
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11758
DataSheet1_Macleayins A From Macleaya Promotes Cell Apoptosis Through Wnt/β-Catenin Signaling Pathway and Inhibits Proliferation, Migration, and Invasion in Cervical Cancer HeLa Ce...
Published 2021“…The Wnt/β-catenin signaling cascade activation was verified using the Dual-Glo® Luciferase assay. We found that MA inhibited the growth of HeLa cells at 72 h (IC<sub>50</sub> = 26.88 µM) via inducing apoptotic process, reduced the proliferation rate by 29.89%, and decreased the cells migration and invasion as compared to the untreated group. …”
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11759
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11760
Loss of capsule significantly reduces <i>N</i>. <i>musculi</i> bacterial burden in the mouse oral cavity but not the gut during persistent colonization.
Published 2022“…<p>A/J mice were orally inoculated with either Wt, Δ<i>228cps</i> or complemented strains (n = 5 per group). …”