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5604
Introducing the 4‑Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates
Published 2016“…Herein we report the synthesis, anticancer potency <i>in vitro</i>, biomolecule interaction, and preliminary mode of action studies of a series of cyclometalated 1,2,3-triazole-derived ruthenium(II) (<b>2a</b>–<b>e</b>) and osmium(II) (<b>3a</b>–<b>e</b>) organometallics of the general form [(η<sup>6</sup>-<i>p</i>-cym)RuCl(κ<sup>2</sup>-C^N-L)] with varying substituents in postion 1 of the 1,2,3-triazole moiety. …”
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5605
DataSheet_1_SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps.pdf
Published 2022“…In the presence of high APOBEC3G levels, however, increased LTR activity upon SRSF1 knockdown facilitated the overall replication, despite decreased vif mRNA levels. In contrast, SRSF1 overexpression significantly impaired HIV-1 post-integration steps including LTR transcription, alternative splice site usage, and virus particle production. …”
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5606
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5607
Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in <i>Trypanosoma cruzi</i>
Published 2017“…Isotretinoin inhibited the polyamine transport, as well as other amino acid transporters from the same protein family (<i>Tc</i>AAAP), with calculated IC<sub>50</sub> values in the range of 4.6–10.3 μM. It also showed a strong inhibition of trypomastigote burst from infected cells, with calculated IC<sub>50</sub> of 130 nM (SI = 920) being significantly less effective on the epimastigote stage (IC<sub>50</sub> = 30.6 μM). …”
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5608
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5609
<i>Bbs1</i><sup><i>M390R/M390R</i></sup> mice have decreased hippocampal proliferation.
Published 2021“…The Red Bar line represents 50μm. G.) Decreased proliferation in the dentate gyrus of P3 <i>Bbs1</i><sup><i>M390R/M390R</i></sup> mice. …”
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5610
Intracellular Delivery of Bioactive Molecules using Light-Addressable Nanocapsules
Published 2010“…We demonstrate this method with the intracellular release of the second messenger IP<sub>3</sub> in CHO-M1 cells and report that calcium responses from the cells changed from a sustained increase to a transient spike when the average number of IP<sub>3</sub> released is decreased below 50 molecules per nanocapsule. …”
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5611
Patient data.
Published 2024“…</p><p>Results</p><p>On average, the time required to move through the obstacle course decreased by 17.0% after the training phase, the number of collisions decreased by 50.0%. …”
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5612
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5613
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5614
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5615
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5616
Reduction of the mean absolute error (MAE) in time for all participant on x-axis.
Published 2019“…<p>A similar effect is observed for y-axis. The MAE obtained using the standard regression (orange circles) decreased significantly when using symbolic regression. …”
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5617
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5618
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5619
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5620
Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells
Published 2024“…Herein, a series of celastrol urea derivatives were developed based on its cocrystal structure with PRDX1, with the aim of pursuing a PRDX1-specific inhibitor. …”