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we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
mg decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
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10 mg » 100 mg (Expand Search), 50 mg (Expand Search)
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Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents
Published 2024“…Compound <b>14b</b> displayed particularly rapid bactericidal effects, slow resistance development, and low cytotoxicity. Moreover, it decreased bacterial loads in the lung, liver, kidney, spleen, and heart and exhibited better antibacterial efficacy (ED<sub>50</sub> = 11.16 mg/kg) than tiamulin (ED<sub>50</sub> = 28.93 mg/kg) in a mouse model of systemic MRSA infection. …”
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Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents
Published 2024“…Compound <b>14b</b> displayed particularly rapid bactericidal effects, slow resistance development, and low cytotoxicity. Moreover, it decreased bacterial loads in the lung, liver, kidney, spleen, and heart and exhibited better antibacterial efficacy (ED<sub>50</sub> = 11.16 mg/kg) than tiamulin (ED<sub>50</sub> = 28.93 mg/kg) in a mouse model of systemic MRSA infection. …”
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289
Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents
Published 2024“…Compound <b>14b</b> displayed particularly rapid bactericidal effects, slow resistance development, and low cytotoxicity. Moreover, it decreased bacterial loads in the lung, liver, kidney, spleen, and heart and exhibited better antibacterial efficacy (ED<sub>50</sub> = 11.16 mg/kg) than tiamulin (ED<sub>50</sub> = 28.93 mg/kg) in a mouse model of systemic MRSA infection. …”
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Temporal profiles of the key BO-NN features.
Published 2020“…Right plot show the gradual decrease in the TM tuning for the features highlighted in <b>c</b> as well as the gradual increase in the temporal response profile (i.e. optimal shifts for the prediction of the key BO-NN features using Praat features shown in <b>a</b>). …”
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