Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Analysis of ATP1A1 protein expression, blood pressure, heart rate and activity in heterozygous <i>ATP1A1^+/−</i> and wild-type male mice. by Victoria L. Herrera (383897)

“…(C) Mean systolic blood pressure ± sem (SBP; mmHg). (D) Mean heart rate ± sem (beats/min; BPM). (E) Mean activity ± sem (Counts/min) in <i>ATP1A1^+/−</i> (solid bars, n = 4) and wild-type (open bars, n = 5) male mice. * <i>P</i> < 0.03, ** <i>P</i> = 0.015 (two-tailed student <i>t</i>-test).…”

Figure 2 by David Heister (426551)

“…C: Individual subject d′ for each n-back condition. (linear regression fit: zero-back r² = 0.58; one-back r² = 0.98; two-back r² = 0.81; three-back r² = 0.89) ** = p<0.01, Bonferroni corrected.…”

Figure 2 by Heidi de Wit (67655)

“…Grey line represents the vesicle distribution in the absence of Munc18-1 as shown before <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000126#pone.0000126-Toonen2" target="_blank">[24]</a>. (C–E) Number of docked vesicles (C), vesicles>0–30 and within 30–100 nm (D), and the total number of vesicles (E). …”

DataSheet_1_Variations in Circulating Levels of Angiopoietin-2 Over Time Are Predictive of Ramucirumab–Paclitaxel Therapy Outcome in Advanced Gastric Cancer: Results of Prospective... by Rosalba D’Alessandro (12357022)

DataSheet_1_Variations in Circulating Levels of Angiopoietin-2 Over Time Are Predictive of Ramucirumab–Paclitaxel Therapy Outcome in Advanced Gastric Cancer: Results of Prospective... by Rosalba D’Alessandro (12357022)

Table_1_Type 2 diabetes attributable to ambient particulate matter pollution: a global burden study from 1990 to 2019.DOCX by Yuyi Sha (18581944)

“…Conversely, regions with high SDI levels like High-income North America demonstrated decreasing trends.</p>Conclusion<p>This study reveals a significant increase in T2D worldwide as a result of APMP from 1990 to 2019, with a particular emphasis on its impact on men, the older adult, and regions with low to middle SDI levels. …”

Fig 2 - by Michael Mackay (411250)

S2 Fig - by Lucille Quénéhervé (14234702)

Effects of TGF-β and iron on 2.2.15 cells. by Sun O. Park (319202)

“…Iron increased and TGF-β decreased HBV replication. (D) Southern blot of native agarose gel confirming changes in HBcAg-associated HBV DNA with chart on right showing densitometric quantitation of bands. …”

Model-averaged coefficients, significance, and relative importance (RI) of the predictor variables for the GLMMs to evaluate effects on: (A) overall pollinator abundance; (B) fruit... by Carmelo Gómez-Martínez (9384385)

Fig 2 - by Emilie Finch (12072790)

Fig 2 - by Ziyan Pan (6579191)

“…<b>e</b>) TGFβ1 increases DNMTs in LX-2 cells. <b>f)</b> 5-Aza decreases DNMTs mRNA expression in HSCs. …”

S2 Data - by Marisa R. Pinson (11659514)

S2 Table - by Marisa R. Pinson (11659514)

Western blot analyses of Bax, Bcl-2 and COX-2. by Maryam Hajrezaie (112763)

“…C) Colon mucosa of the group treated with 2.5 mg/kg copper (II) complex. D) Colon mucosa of the group treated with 5 mg/kg copper (II) complex. …”