Intracellular Ca²⁺ signaling and IP3R2 expression are decreased in <i>Tcirg1</i>-knockdown osteoclasts. by Dongyan Zhang (640677)

Simulation results predict the role of AC in driving the in-phase behavior and decreasing time delay for inversely out-of-phase behavior. by Lingxia Qiao (19996756)

MeCP2 expression in glutamatergic dLGN neurons decreases upon dark-rearing. by Yuki Yagasaki (402238)

Glutathione metabolism decreases during infection with <i>P</i>. <i>aeruginosa</i> in a FadE2-dependent manner. by Siraje Arif Mahmud (3188391)

Correlation between decreased ferroportin (Fpn) protein level and increased hepcidin (Hepc) mRNA expression in the liver of <i>ms/−</i> males. by Małgorzata Lenartowicz (150659)

High-throughput drug screen reveals HDAC and proteasome inhibitors as potent drug classes against synovial sarcoma. by Aimée N. Laporte (3617987)

“…Total score across the six cell lines was calculated out of 6. (D) IC₅₀ measurements were calculated for drug screen hits quisinostat (HDAC inhibitor), BGT-226 (PI3K/mTOR inhibitor), bortezomib (proteasome inhibitor) as compared with the current standard for synovial sarcoma treatment doxorubicin (cytotoxic DNA/RNA intercalating agent and topoisomerase inhibitor), in a panel of six human SS18-SSX positive cell lines and two control cell lines (HEK293T, MCF7). …”

In-phase (A) and opposed phase (B) chemical shift MR images of a 51-year-old male demonstrate hepatic steatosis, consistent with areas of decreased signal intensity on an opposed-p... by Andrzej Cieszanowski (635105)

HDAC inhibition prevents aggresome formation in response to proteasome inhibitors, and combination treatment leads to endoplasmic reticulum stress. by Aimée N. Laporte (3617987)

“…<p>(A) Knockdown of HDAC6 results in decreased levels of LC3B in the SYO-1 synovial sarcoma cell line. …”

histomorphometric results obtained on 2D histological sections or on 3D models prepared by microCT. by Eric Aguado (687890)

Genes showing decreased expression in D381 following 2h exposure to Doxycycline. by Wanjun Qi (5571359)

Ki67 and cyclin D2 mRNA is significantly decreased relative to age. by Yanhui Huang (656379)

“…<p>qRT-PCR was used to analyze Ki67 and cyclin D2 mRNA levels. Both Ki67 (A) and cyclin D2 (B) were decreased with age. …”

Host survival and pathogen loads during <i>Streptococcus pneumoniae</i> infection of flies with manipulated adenosine levels. by Adam Bajgar (730380)

“…(E) and (F) Pathogen loads within the first 24 hours post-infection in logarithmic scale (values follow lognormal distribution) with significant differences marked by asterisks (color determines the compared genotype to control, i.e. either <i>w</i> or <i>ADGF-A[RNAi])</i>; <i>adoR</i> increases while both <i>adgf-a/+</i> and <i>Hml>ADGF-A[RNAi]</i> decreases the pathogen loads (lines connect the mean values with SEM as error bars; see also <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007022#ppat.1007022.s002" target="_blank">S2 Fig</a> for appropriate dot plots). …”

CHIKV-infected primary joint tissue fibroblasts display decreased MHC-I cell surface expression. by Brian C. Ware (8544672)

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…The antiproliferative activity of the novel <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. <i>N</i>-(4-Bromophenyl)-4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine <b>4f</b>, <i>N</i>-(4-chlorophenyl)-4,6-bis­(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-amine <b>5c</b>, and 4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-<i>N</i>-(4-methoxyphenyl)-1,3,5-triazin-2-amine <b>5d</b> showed promising activity against these cancer cells: <b>4f</b> [(IC₅₀ = 4.53 ± 0.30 μM (MCF-7); 0.50 ± 0.080 μM (HCT-116); and 3.01 ± 0.49 μM (HepG2)]; <b>5d</b> [(IC₅₀ = 3.66 ± 0.96 μM (HCT-116); and 5.42 ± 0.82 μM (HepG2)]; and <b>5c</b> [(IC₅₀ = 2.29 ± 0.92 μM (MCF-7)]. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…The antiproliferative activity of the novel <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives was studied against three cancer cell lines, namely, MCF-7, HCT-116, and HepG2. <i>N</i>-(4-Bromophenyl)-4-(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-amine <b>4f</b>, <i>N</i>-(4-chlorophenyl)-4,6-bis­(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-amine <b>5c</b>, and 4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-<i>N</i>-(4-methoxyphenyl)-1,3,5-triazin-2-amine <b>5d</b> showed promising activity against these cancer cells: <b>4f</b> [(IC₅₀ = 4.53 ± 0.30 μM (MCF-7); 0.50 ± 0.080 μM (HCT-116); and 3.01 ± 0.49 μM (HepG2)]; <b>5d</b> [(IC₅₀ = 3.66 ± 0.96 μM (HCT-116); and 5.42 ± 0.82 μM (HepG2)]; and <b>5c</b> [(IC₅₀ = 2.29 ± 0.92 μM (MCF-7)]. …”

Data Sheet 1_Secretoneurin plasma levels are decreased after catheter ablation for atrial fibrillation—patients with AF produce lower SN levels than healthy individuals: the SAFE r... by Jiří Plášek (21805048)

“…ClinicalTrials.gov ID: NCT05794464.</p>Results<p>A total of 137 patients (64% males, age 63 ± 11) and 34 healthy individuals (38% males, mean age 31 ± 7.1) were included in the analysis. …”

NFκB-p50 knockdown decreases CD44 expression. by Shannon M. Smith (115335)

CHIP-T246M expressed from the endogenous locus results is regulated post-translationally resulting in decreased steady-state protein levels, however, interactions between CHIP and... by Chang-he Shi (5315918)

Both with somatic and with dendritic stimulation, pyramidal cell burst firing decreases as the apical dendrite becomes shorter. by Ronald A. J. van Elburg (80591)

Both with somatic and with dendritic stimulation, pyramidal cell burst firing decreases as the apical dendrite becomes shorter. by Ronald A. J. van Elburg (80591)