Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”

<i>dVMAT</i> mutants show decreased histamine labeling in subretinal glia. by Rafael Romero-Calderón (170680)

“…Labeling in the medulla (asterisks) is less reduced in <i>dVMAT</i>^Δ14 and is strong in the proximal lamina (small arrow). Bars: (A) 50 microns, (B–G) 25 microns, (H,I) 50 microns.…”

Anaesthesia decreases stimulus-specific suppression on probe-responses only after communication context. by Luciana López-Jury (8601540)

Originally developed disturbance-loading system. by Yahiko Takeuchi (4740036)

“…In conclusion, older individuals increased instability in the lateral direction of the head and decreased righting angle displacement and angular velocity of the head during crossover steps. …”

Data for graphs (representative values). by Yahiko Takeuchi (4740036)

“…In conclusion, older individuals increased instability in the lateral direction of the head and decreased righting angle displacement and angular velocity of the head during crossover steps. …”

MRI imaging and analysis, revealing decreased volume and thickness of placentas exposed to intrauterine inflammation. by Solange N. Eloundou (6551627)

Virchow’s Triad, including hypercoagulability suggested by decreased fibrinogen in placentas exposed to intrauterine inflammation. by Solange N. Eloundou (6551627)

ABT199 inhibits ALK ^mutant kinase activity and decreases it phosphorylation. by Richard Junior Zapata Dongo (17912565)

OA animals had decreased gastrocnemius area, and increased IL-1β expression. by Jordana Miranda de Souza Silva (5154743)

AMPs are increased in lesional HS, but DCD and other sweat-gland associated proteins are decreased. by Margaret Coates (6058580)

“…<p>(A) Volcano plot showing increased or decreased genes in HS. …”

Fig 7 - by Eric Behle (11426692)

Elevated phospholipid level in yeast decreases the sensitivity of replicating tombusvirus RNA to the reconstituted RNAi. by Nikolay Kovalev (184967)

Mean observer DCCR (%) and DDR (%) at C3-4 in neutral and flexed neck positions in horses that were not operated (n = 18) versus were operated (n = 4) at this site. by Devon England (21262225)

Mean observer DCCR (%) and DDR (%) at C6-7 in neutral, flexed and extended neck positions in horses that were not operated (n = 13) versus operated (n = 9) at this site. by Devon England (21262225)

Mean observer DCCR (%) and DDR (%) at C5-6 in neutral, flexed and extended neck positions in horses that were not operated (n = 16) versus operated (n = 6) at this site. by Devon England (21262225)

Mean observer DCCR (%) and DDR (%) at C4-5 in neutral, flexed and extended neck positions in horses that were not operated (n = 10) versus operated (n = 12) at this site. by Devon England (21262225)

Pharmacological Notch inhibition decreases the penetrance of <i>mef2ca</i>-associated phenotypes without producing a skeletal phenotype in genetic wild types. by Juliana Sucharov (8067371)

Decreasing oxygen saturation with corresponding levels of NLR and D-dimer for understanding the interplay of inflammation. by Narendran Gopalan (110148)

Temsirolimus-induced Akt phosphorylation is decreased by BEZ235 and ZSTK474, but not by AZD6244. by Shujie Yang (200261)

Decreased cell viability after VGLUT2-Venus transfection using the NTS-polyplex. by Daniel Hernandez-Baltazar (291985)