Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A₃ Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [³⁵S]GTPγS binding <i>E</i>_max, with only <b>12b</b> trending toward decreasing the agonist EC₅₀. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”

Table 1_Association of memory function with COVID-19 outcomes in adults aged 50 years and older: analysis of three prospective cohorts.docx by Juanjuan Shi (8192751)

“…The aORs for COVID-19 mortality were 1.06 (95% CI, 0.93–1.20) and 1.14 (95% CI, 1.01–1.28) per word decrease in immediate and delayed 10-words recall in SHARE, respectively. …”

Local sensitivity analysis of procoagulants, fibrin, F1.2 flux, and TAT flux. by Jason Chen (15937)

High-dose AA treatment decreases IL-6 and HTLV-1 p19 levels in HTLV-1-infected cell line supernatant. by Britta Moens (149041)

Schematic of the reduced model. by Jason Chen (15937)

The potency of the blockage of FXIa varies over the subsets of fibrin concentration. by Jason Chen (15937)

Effect of inhibitory antibodies and human serum on NA enzymatic function ELLA and NA Star. by Harrison Powell (9040128)

Local sensitivity analysis of total thrombin, free, and bound thrombin in the clot. by Jason Chen (15937)

Plasma protein levels and thrombin binding sites distribution of the subsets of top and bottom 2% of fibrin concentration of 10,000 simulations. by Jason Chen (15937)

Flow chart of performed HLA class II typing in T1DM population. by Silvia Ricci (450811)

Silencing of <i>Bma-aldolase-2</i> decreases <i>Wolbachia</i> load in adult female worms and induces apoptosis in developing embryos. by Denis Voronin (257924)

Reduced ezrin or p130Cas expression in ES2 cells resulted in decreased cell branching capacity on Matrigel and reduced invasion ability. by Vered Horwitz (3117960)

“…ES2 cells with reduced ezrin expression (ES2-T2) showed 50% decrease in invasion ability compared the cells transfected with no plasmid (ES2-C1) and non-transfected cells (ES2-C2) (*, p<0.01). …”

Proportions of activated (CD38+HLA-DR+) and cycling (Ki67+) CD4+ and CD8+ T cells decreased following initiation of ART. by Nicholas T. Funderburg (379171)

“…<div><p>Among both A) CD4+ and B) CD8+ T cell populations, initiation of raltegravir plus emtricitabine/tenofovir resulted in a significant decrease from baseline in the proportion of activated cells by 2 days and 7 days (p= 0.05 and 0.015, respectively). …”

Supplementary file 1_Water stress reduces cellulose deposition in the cell wall and increases wax content, resulting in decreased fiber quality.docx by Yongchao Han (10797698)

“…At 30 DPA, compared to the WW treatment, the sucrose contents in SD217 and XC7 fibers decreased by 18.66% and 12.85%, while cellulose contents dropped by 9.91% and 17.17%, respectively, resulting in a significant decrease in the thickness of the cell walls by 10.59% and 9.50% respectively. …”

Supplementary file 2_Water stress reduces cellulose deposition in the cell wall and increases wax content, resulting in decreased fiber quality.xlsx by Yongchao Han (10797698)

“…At 30 DPA, compared to the WW treatment, the sucrose contents in SD217 and XC7 fibers decreased by 18.66% and 12.85%, while cellulose contents dropped by 9.91% and 17.17%, respectively, resulting in a significant decrease in the thickness of the cell walls by 10.59% and 9.50% respectively. …”

<i>sirB⁻</i>, Vic1, Vic2 and T6SS-double mutants showed decreased virulence in planta. by Johanna Nykyri (124297)

Image_4_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.TIF by Dengpan Bu (369549)

Image_1_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.TIF by Dengpan Bu (369549)

Image_3_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.TIF by Dengpan Bu (369549)

Image_5_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.TIF by Dengpan Bu (369549)