OPTN degrades GSK3β via activating LC3-mediated autophagy. by Xiao Chen Shi (8611887)

Weak Allele of <i>fzy-1</i>(<i>h1983</i>) Suppressed Neuron Decrease Phenotype of <i>bub-1</i>(<i>fw8</i>). by Xiangming Wang (372213)

Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... by Akanksha Upadhyay (6732857)

“…In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline–metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. …”

Supplementary file 1_Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomi... by Abdullah M. Sayed Ahmad (18592582)

“…</p>Methods<p>Fourteen participants with chronic SCI received an average of 40 sessions with 30 Hz transspinal stimulation delivered for 30 min during standing (active: n = 4; sham: n = 5) or supine (active: n = 5) followed by 30-min of robotic assisted step training. Before and 1–2 days after completion of all training sessions, we assessed the soleus H-reflex homosynaptic depression and soleus H-reflex recruitment curve, and the amount of reciprocal and presynaptic inhibition following conditioning stimulation of the antagonistic common peroneal nerve.…”

Inhibition of GSK3β rescues impaired skeletal muscle regeneration induced by <i>Optn</i> KD. by Xiao Chen Shi (8611887)

Exposure of HOB to chemotherapeutic agents or rTGF-β1 diminished the ability of HOB to support human embryonic stem cells and decreased pro-B cell interaction with HOB. by Stephanie L. Rellick (182765)

Quantification of intramuscular fat in patients with late-onset Pompe disease by conventional magnetic resonance imaging for the long-term follow-up of enzyme replacement therapy by André Lollert (4746897)

“…A significant increase in the MR-derived fat fraction of the psoas muscle was found between baseline and follow-up 1 (<i>P</i> = 0.016), as was a significant decrease in the performance on the 6-minute walk test (<i>P</i> = 0.006) and 4-step stair climb test (<i>P</i> = 0.034), as well as plasma creatine kinase (<i>P</i> = 0.016). …”

Related to Fig 1. by Amy E. Schade (15368259)

Inhibition of GSK3β rescues impaired myogenesis during myoblast differentiation induced by <i>Optn</i> KD. by Xiao Chen Shi (8611887)

OPTN is essential for myogenesis during skeletal muscle regeneration in response to muscle injury. by Xiao Chen Shi (8611887)

Multi imaging of <i>S. aureus</i> and <i>P. aeruginosa</i> by means of immunofluorescence and immunogold electron microscopy. by Lars Bräuer (287741)

“…<p>Detection of SP-A, -B, -C and –D by means of immunofluorescence (IHC) and immunogold electron microscopy (EM) for <i>S. aureus</i> (A) and <i>P. aeruginosa</i> (B). …”

OPTN degrades GSK3β via activating LC3-mediated autophagy. by Xiao Chen Shi (8611887)

<i>F</i>. <i>oxysporum</i> f. sp. <i>albedinis</i> genome code for a large repertoire of secreted proteins. by Maryam Rafiqi (12647200)

Locomotion and turning angle sizes of adult <i>D</i>. <i>melanogaster</i>, <i>D</i>. <i>simulans</i>, <i>D immigrans</i>, <i>D</i>. <i>subobscura</i> and <i>D pavani</i> in Petri d... by Jeannette Silva-López (16541854)

Flow chart for patients inclusion. by Haruka Imai (3703819)

“…Following this, antibiotic prescription was associated with a decreased 28-day mortality rate (2.3% vs. 3.6%) and in-hospital mortality rate (4.0% vs. 5.0%) compared with the control group. …”

The outcome measures in IPTW analysis. by Haruka Imai (3703819)

“…Following this, antibiotic prescription was associated with a decreased 28-day mortality rate (2.3% vs. 3.6%) and in-hospital mortality rate (4.0% vs. 5.0%) compared with the control group. …”

Contingency relation between IPI before and IPI after each pulse. by Laura N. Kloepper (8173881)

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”