Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis by Yongqiang Sun (8226111)

“…CDC2-like kinase 2 (CLK2) could modulate Wnt signaling via alternative splicing of Wnt target genes and further affect bone differentiation, chondrocyte function, and inflammation, making CLK2 an attractive target for OA therapy. In this study, we designed and synthesized a series of highly potent CLK2 inhibitors based on <b>Indazole 1</b>. …”

Table_1_Empagliflozin Decreases Lactate Generation in an NHE-1 Dependent Fashion and Increases α-Ketoglutarate Synthesis From Palmitate in Type II Diabetic Mouse Hearts.DOCX by Hong Zhang (25820)

“…However, EMPA did specifically decrease cardiac lactate labeling in the ¹³C glucose perfusions (¹³C labeling of lactate: 58 ± 2% vs. 50 ± 3%, for vehicle and EMPA, respectively; P = 0.02), without changes in other glucose metabolic pathways. …”

Triclosan Dioxygenase: A Novel Two-component Rieske Nonheme Iron Ring-hydroxylating Dioxygenase Initiates Triclosan Degradation by Yiran Yin (19144130)

“…The highest amino acid identity of TcsA and the large subunits of other dioxygenases in the same family was only 35.50%, indicating that TcsAB is a novel dioxygenase. …”

The second-order rate-yield tradeoff demonstrated by decreasing the P/O ratio and and knocking out <i>gnd</i> (“Δ<i>gnd</i>”) in ME-model simulations. by Chuankai Cheng (6791417)

Number of bars of length greater than <i>ℓ</i> = 4000 in the barcodes obtained via the binary model (left) and the fuzzy binary model (right) as a function of <i>τ</i>. by Samir Chowdhury (5715338)

LDHA is increased in bleomycin-induced pulmonary fibrosis. by Jennifer L. Judge (5278415)

Water supply head entries, a raw measure of rat’s activity, show rapid increase at the time the lights were turned on at 06:00 but no change at the time the lights were turned off.... by Piotr Popik (292215)

Global positioning system (GPS) tracks. by Prateep Duengkae (7485500)

Concurrent mixed methods design diagram. by Esario IV Daguman (21474116)

“…2) Does Safe Steps improve people’s service experience, perceived staff action towards violence prevention, and nurses’ professional quality of life and emotionally intelligent workplace behaviours? …”

The guiding map. by Esario IV Daguman (21474116)

“…2) Does Safe Steps improve people’s service experience, perceived staff action towards violence prevention, and nurses’ professional quality of life and emotionally intelligent workplace behaviours? …”

Effects of changes in anionic phospholipids on SAUR63 localization. by Punita Nagpal (185838)

Whole-body metabolic indicators of tissue deposition. by Natalie E. Diether (16705804)

Loss of exostosin-1 (Ext1) and specific reduction of HS in fibroblasts in <i>S100a4-Cre; Ext1</i>^<i>f/f</i> mice. by Ayumi Niwa (6256790)

Muscle nuclei clustering phenotype observed in <i>attP40</i> larvae. by Kevin van der Graaf (14259532)

Passive transfer of humanized anti-NS1 mAb 33D2 into DENV-inoculated mice decreases viral titer and NS1 level in mouse sera. by Sen-Mao Tien (12481273)

Effects on nuclei clustering of inserting Gal4-regulated TRiP <i>spatacsin (spat)</i> into <i>attP40</i>. by Kevin van der Graaf (14259532)

TRiP <i>atl</i> can have dominant effects on nuclear clustering in some genetic backgrounds. by Kevin van der Graaf (14259532)

<i>hlh-26</i> is required for SagA-mediated protection. by Yu Sang (2551267)

vFLIP maintains intestinal barrier integrity in a short term model <i>in vivo</i>. by Barbara Ruder (8379354)

Kaplan-Meier analyses of the differential protective effects of a history of TC on BC-specific survival between young and old patients. by Weiwei Cheng (582223)