The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice by Tatsuya Shimomatsu (1545943)

“…<p><i>Objectives</i>: To evaluate the effect and safety of hydroxychloroquine (HCQ) on lupus erythematosus (LE)-like skin lesions in the MRL/lpr mouse, a model for systemic LE (SLE).</p> <p><i>Methods</i>: We divided the MRL/lpr mice into three groups that were given: (1) drinking water, (2) HCQ at a dose of 4 mg/kg/d, or (3) HCQ at a dose of 40 mg/kg/d. …”

Acute TTBK1 inhibition reduces tau phosphorylation at disease relevant sites <i>in vivo</i>. by Gregory M. Dillon (8681430)

“…(A) At the highest dose tested (75mg/kg), there was a significant decrease in tau phosphorylation at several sites when quantified by immunoblotting (S422, AT180, S396, and AT8). …”

Epithelial and morphological changes observed in lungs with anti-miR and mimic treatments. by Sana Mujahid (280955)

“…Point count analysis was done by placing a 50μm grid on histological sections. Mimic 221 had a 15.2% decrease and anti-221 a 10.5% decrease in mesenchymal area compared to controls. …”

Video1_One-year real-world experience with mavacamten and its physiologic effects on obstructive hypertrophic cardiomyopathy.mov by Daniel Seung Kim (19510291)

“…Moreover, in our center's experience, neither arrhythmia burden, nor contractility have worsened in the vast majority of patients: we note a clinically insignificant mean decrease in left ventricular ejection fraction (LVEF), with only two patients requiring temporary mavacamten discontinuance for LVEF < 50%. …”

Video1_One-year real-world experience with mavacamten and its physiologic effects on obstructive hypertrophic cardiomyopathy.mov by Daniel Seung Kim (19510291)

“…Moreover, in our center's experience, neither arrhythmia burden, nor contractility have worsened in the vast majority of patients: we note a clinically insignificant mean decrease in left ventricular ejection fraction (LVEF), with only two patients requiring temporary mavacamten discontinuance for LVEF < 50%. …”

Image_4_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

Image_6_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

Image_3_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

Image_5_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

Image_1_STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.TIF by Simon J. Houtman (8716335)

“…EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. …”

Rosiglitazone treatment preserves carnitine homeostasis in lambs with increased pulmonary blood flow. by Shruti Sharma (308114)

“…CPT1, CPT2 and CrAT protein levels were then determined by Western blot analyses. There was a significant decrease in CPT1 (A) and CrAT (C) protein levels in the vehicle-treated Shunt lambs. …”

Correction of Matrix Effects for Reliable Non-target Screening LC–ESI–MS Analysis of Wastewater by Selina Tisler (6062354)

“…As a first step, the “dilute and shoot” approach was used to determine the optimal relative enrichment factor (REF) for a direct comparison between wastewater influent (REF 10) and effluent (REF 50) extracts. …”

GFP mRNA and protein suppression in THP-1 cells. by Breanne Landry (138815)

“…<p>(<b>A</b>) Decrease in GFP mRNA levels, and (<b>B</b>) decrease in GFP protein levels (i: based on mean GFP fluorescence and ii: based on GFP-positive cell population). …”

Influence of UGT2B10 Genotype on Urinary Excretion of 4‑(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-<i>N-</i>glucuronide by African American Smokers by Sharon E. Murphy (272512)

“…In summary, the high prevalence of a <i>UGT2B10</i> splice variant among African Americans results in lower NNAL-<i>N</i>-glucuronidation but only a small decrease in total NNAL glucuronidation. …”

Non-contributory pension programs and frailty of older adults: Evidence from Mexico by Emma Aguila (3461918)

Data_Sheet_1_Quantifying Pesticide Exposure Risk for Monarch Caterpillars on Milkweeds Bordering Agricultural Land.PDF by Paola Olaya-Arenas (6841796)

“…For thiamethoxam, isolating milkweeds 50–100 m from the nearest corn or soybean field tended to decrease the concentration and likelihood of detecting residues, whereas landscape composition surrounding milkweed sites had comparatively weak predictive power. …”

miR-27b regulates ASC-mediated suppression of CFSE-labeled allogeneic CD4⁺ T cell proliferation. by Kuang-Den Chen (322973)

Imbalanced SCP dynamics disturb neurite outgrowth. by Arjun Singh Yadaw (6654872)

“…To simulate the effect of uncoordinated vesicle SCP dynamics we decreased the count and production rate of v-SNARE V to 25%, 50% and 75% of the original prediction, without modifying any other parameters. …”

Schwann cell IR and remyelination in the injured sciatic nerve. by Alexander Berg (391857)

“…We observed a decrease in MBP IR ratio both for WT and <i>GFAP^–/–Vim^–/–</i> mice but did not detect any difference between the two groups of mice (D). …”

Exome sensitivity with varying exome site density. by Zhong Zhuang (303261)